A phase 1 clinical trial shows safe, sustained, AAV-mediated expression of IL-1Ra in the human osteoarthritic knee joint.
De la Vega RE, Sellon JL, Smith J, Wisniewski SJ, Jurisson ML, Frick MA, Scrabeck TL, Block JB, Mills CJ, Pohlkamp ZW, Coenen MJ, Hawse GP, Abdul TY, Conaghan P, Keravala A, Chalberg TW, Robbins PD, Ghivizzani SC, Evans CH.
De la Vega RE, et al. Among authors: block jb.
Sci Transl Med. 2025 Jun 4;17(801):eadu9804. doi: 10.1126/scitranslmed.adu9804. Epub 2025 Jun 4.
Sci Transl Med. 2025.
PMID: 40465688
Free article.
Clinical Trial.