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Endoplasmic reticulum stress disrupts signaling via altered processing of transmembrane receptors.
Bosakova M, Abraham SP, Wachtell D, Zieba JT, Kot A, Nita A, Czyrek AA, Koudelka A, Ursachi VC, Feketova Z, Rico-Llanos G, Svozilova K, Kocerova P, Fafilek B, Gregor T, Kotaskova J, Duran I, Vanhara P, Doubek M, Mayer J, Soucek K, Krakow D, Krejci P. Bosakova M, et al. Among authors: soucek k. Cell Commun Signal. 2025 Apr 30;23(1):209. doi: 10.1186/s12964-025-02208-w. Cell Commun Signal. 2025. PMID: 40307870 Free PMC article.
Tumor suppressor candidate 3 (TUSC3) prevents the epithelial-to-mesenchymal transition and inhibits tumor growth by modulating the endoplasmic reticulum stress response in ovarian cancer cells.
Kratochvílová K, Horak P, Ešner M, Souček K, Pils D, Anees M, Tomasich E, Dráfi F, Jurtíková V, Hampl A, Krainer M, Vaňhara P. Kratochvílová K, et al. Among authors: soucek k. Int J Cancer. 2015 Sep 15;137(6):1330-40. doi: 10.1002/ijc.29502. Epub 2015 Mar 21. Int J Cancer. 2015. PMID: 25735931
Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2.
Němec V, Remeš M, Beňovský P, Böck MC, Šranková E, Wong JF, Cros J, Williams E, Tse LH, Smil D, Ensan D, Isaac MB, Al-Awar R, Gomolková R, Ursachi VC, Fafílek B, Kahounová Z, Víchová R, Vacek O, Berger BT, Wells CI, Corona CR, Vasta JD, Robers MB, Krejci P, Souček K, Bullock AN, Knapp S, Paruch K. Němec V, et al. Among authors: soucek k. J Med Chem. 2024 Aug 8;67(15):12632-12659. doi: 10.1021/acs.jmedchem.4c00629. Epub 2024 Jul 18. J Med Chem. 2024. PMID: 39023313 Free PMC article.
FoxO1/Rictor axis induces a nongenetic adaptation to ibrutinib via Akt activation in chronic lymphocytic leukemia.
Ondrisova L, Seda V, Hlavac K, Pavelkova P, Hoferkova E, Chiodin G, Kostalova L, Mladonicka Pavlasova G, Filip D, Vecera J, Zeni PF, Oppelt J, Kahounova Z, Vichova R, Soucek K, Panovska A, Plevova K, Pospisilova S, Simkovic M, Vrbacky F, Lysak D, Fernandes SM, Davids MS, Maiques-Diaz A, Charalampopoulou S, Martin-Subero JI, Brown JR, Doubek M, Forconi F, Mayer J, Mraz M. Ondrisova L, et al. Among authors: soucek k. J Clin Invest. 2024 Oct 22;134(23):e173770. doi: 10.1172/JCI173770. J Clin Invest. 2024. PMID: 39436708 Free PMC article.
eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations.
Valcikova B, Vadovicova N, Smolkova K, Zacpalova M, Krejci P, Lee S, Rauch J, Kolch W, von Kriegsheim A, Dorotikova A, Andrysik Z, Vichova R, Vacek O, Soucek K, Uldrijan S. Valcikova B, et al. Among authors: soucek k. Proc Natl Acad Sci U S A. 2024 Oct 29;121(44):e2321305121. doi: 10.1073/pnas.2321305121. Epub 2024 Oct 22. Proc Natl Acad Sci U S A. 2024. PMID: 39436655 Free PMC article.
Expandable Lung Epithelium Differentiated from Human Embryonic Stem Cells.
Kotasová H, Capandová M, Pelková V, Dumková J, Koledová Z, Remšík J, Souček K, Garlíková Z, Sedláková V, Rabata A, Vaňhara P, Moráň L, Pečinka L, Porokh V, Kučírek M, Streit L, Havel J, Hampl A. Kotasová H, et al. Among authors: soucek k. Tissue Eng Regen Med. 2022 Oct;19(5):1033-1050. doi: 10.1007/s13770-022-00458-0. Epub 2022 Jun 7. Tissue Eng Regen Med. 2022. PMID: 35670910 Free PMC article.
193 results