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Page 1
Polygenic and developmental profiles of autism differ by age at diagnosis.
Zhang X, Grove J, Gu Y, Buus CK, Nielsen LK, Neufeld SAS, Koko M, Malawsky DS, Wade EM, Verhoef E, Gui A, Hegemann L; APEX Consortium; iPSYCH Autism Consortium; PGC-PTSD Consortium; Geschwind DH, Wray NR, Havdahl A, Ronald A, St Pourcain B, Robinson EB, Bourgeron T, Baron-Cohen S, Børglum AD, Martin HC, Warrier V. Zhang X, et al. Nature. 2025 Oct;646(8087):1146-1155. doi: 10.1038/s41586-025-09542-6. Epub 2025 Oct 1. Nature. 2025. PMID: 41034588 Free PMC article.
Epigenetic clocks and longitudinal plasma biomarkers of Alzheimer's disease.
Zhang B, McEvoy LK, Nguyen S, Espeland MA, Rapp SR, Horvath S, Lu A, LaCroix AZ, Nievergelt CM, Maihofer AX, Resnick SM, Mielke MM, Beckman K, Li D, Silver B, Manson JE, Ferrucci L, Shadyab AH. Zhang B, et al. Among authors: maihofer ax. medRxiv [Preprint]. 2025 Aug 14:2025.08.12.25333453. doi: 10.1101/2025.08.12.25333453. medRxiv. 2025. PMID: 40832399 Free PMC article. Preprint.
Immune, Developmental, and Synaptic Pathways Define Bipolar Disorder Clinical Heterogeneity.
van der Veen T, Tesfaye M, Yang JMK, Boltz T, David FS, Crinion S, Koromina M, Andlauer TFM, Bigdeli TB, Coombes BJ, Greenwood TA, Panagiotaropoulou G, Parker N, Sung H, Bass N, Coleman JRI, Guzman-Parra J, Kalman JL, McGrouther CC, Mitchell BL, Rangan AV, Scott K, Shadrin A, Smith DJ, Vreeker A, Adorjan K, Albani D, Alemany S, Alliey-Rodriguez N, Antoniou A, Bauer M, Beins EC, Boks MP, Bosch R, Brumpton BM, Brunkhorst-Kanaan N, Budde M, Byerley W, Cabana-Domínguez J, Cairns MJ, Carpiniello B, Casas M, Cervantes P, Chatzinakos C, Clarke TK, Claus I, Cruceanu C, Cuellar-Barboza A, Czerski PM, Dafnas K, Dale AM, Dalkner N, DePaulo JR, Degenhardt F, Djurovic S, Escott-Price V, Fanous AH, Fellendorf FT, Ferrier IN, Forty L, Frank J, Frei O, Freimer NB, Garnham J, Gizer IR, Gordon SD, Gordon-Smith K, Hahn T, Marian L, Harder A, Hautzinger M, Heilbronner U, Hellgren D, Herms S, Hickie IB, Hoffmann P, Holmans PA, Jamain S, Jonsson L, Kennedy JL, Kittel-Schneider S, Knowles JA, Koch E, Kogevinas M, Kranz TM, Kushner SA, Lavebratt C, Lawrence J, Leber M, Lind PA, Lucae S, Lundberg M, MacIntyre DJ, Maier W, Maihofer AX, Malaspina D, Manchia M, Maratou E, Martinsson L, McInnis MG, McK… See abstract for full author list ➔ van der Veen T, et al. Among authors: maihofer ax. medRxiv [Preprint]. 2025 Jun 27:2025.06.23.25330155. doi: 10.1101/2025.06.23.25330155. medRxiv. 2025. PMID: 40666370 Free PMC article. Preprint.
Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses.
Shen J, Valentim W, Friligkou E, Overstreet C, Choi KW, Koller D, O'Donnell CJ, Stein MB, Gelernter J; Posttraumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium; Lv H, Sun L, Falcone GJ, Polimanti R, Pathak GA. Shen J, et al. Nat Commun. 2025 Jul 1;16(1):5631. doi: 10.1038/s41467-025-60487-w. Nat Commun. 2025. PMID: 40595462 Free PMC article.
The Landscape of Shared and Divergent Genetic Influences across 14 Psychiatric Disorders.
Grotzinger AD, Werme J, Peyrot WJ, Frei O, de Leeuw C, Bicks LK, Guo Q, Margolis MP, Coombes BJ, Batzler A, Pazdernik V, Biernacka JM, Andreassen OA, Anttila V, Børglum AD, Cai N, Demontis D, Edenberg HJ, Faraone SV, Franke B, Gandal MJ, Gelernter J, Hettema JM, Jonas KG, Knowles JA, Koenen KC, Maihofer AX, Mallard TT, Mattheisen M, Mitchell KS, Neale BM, Nievergelt CM, Nurnberger JI, O'Connell KS, Robinson EB, Sanchez-Roige SS, Santangelo SL, Stefansson H, Stefansson K, Stein MB, Strom NI, Thornton LM, Tucker-Drob EM, Verhulst B, Waldman ID, Walters GB, Wray NR; Anxiety Disorders Working Group; Attention-Deficit/Hyperactivity Disorder (ADHD) Working Group; Autism Spectrum Disorders Working Group; Bipolar Disorder Working Group; Eating Disorders Working Group; Major Depressive Disorder Working Group; Nicotine Dependence GenOmics (iNDiGO) Consortium; Obsessive-Compulsive Disorder Working Group; Post-Traumatic Stress Disorder Working Group; Schizophrenia Working Group; Substance Use Disorders Working Group; Tourette Syndrome Working Group; Lee PH, Kendler KS, Smoller JW. Grotzinger AD, et al. Among authors: maihofer ax. medRxiv [Preprint]. 2025 Jan 15:2025.01.14.25320574. doi: 10.1101/2025.01.14.25320574. medRxiv. 2025. PMID: 40568675 Free PMC article. Preprint.
PTSD and epigenetic aging: a longitudinal meta-analysis.
Zhao X, Katrinli S, McCormick BM, Miller MW, Nugent NR, Wani AH, Zannas AS, Aiello AE, Baker DG, Boks MP, Chen CY, Fortier CB, Gelernter J, Geuze E, Koenen KC, Linnstaedt SD, Luykx JJ, Maihofer AX, McLean SA, Milberg WP, Ratanatharathorn A, Ressler KJ, Risbrough VB, Rutten BPF, Smoller JW, Stein MB, Ursano RJ, Vermetten E, Vinkers CH, Ware EB, Wildman DE, Zhao Y; PGC-PTSD Epigenetics Workgroup; Logue MW, Nievergelt CM, Smith AK, Uddin M, Wolf EJ. Zhao X, et al. Among authors: maihofer ax. Psychol Med. 2025 May 14;55:e142. doi: 10.1017/S0033291725000558. Psychol Med. 2025. PMID: 40366073 Free PMC article.
Cell-type-specific and inflammatory DNA methylation patterns associated with PTSD.
Smith AK, Katrinli S, Maihofer AX, Aiello AE, Baker DG, Boks MP, Brick LA, Chen CY, Dalvie S, Fani N, Fortier CB, Gelernter J, Geuze E, Gillespie CF, Hayes JP, Hong S, Kessler RC, King AP, Koen N, Koenen KC, Liberzon I, Linnstaedt SD, McLean SA, Michopoulos V, Milberg WP, Miller MW, Mufford MS, Nugent NR, Orcutt HK, Powers A, Rauch SAM, Ressler KJ, Risbrough VB, Rutten BPF, Smoller JW, Stein DJ, Stein MB, Ursano RJ, Verfaellie MH, Vermetten E, Vinkers CH, Wani AH, WareVinkers EB, Wildman DE, Wolf EJ, Zhao Y, Logue MW, Nievergelt CM, Uddin M, Zannas AS; PGC-PTSD Epigenetics Workgroup; PsychENCODE PTSD Brainomics Project; Traumatic Stress Brain Research Group. Smith AK, et al. Among authors: maihofer ax. Brain Behav Immun. 2025 Aug;128:540-548. doi: 10.1016/j.bbi.2025.04.031. Epub 2025 Apr 24. Brain Behav Immun. 2025. PMID: 40286993 Free article.
Towards Scalable Biomarker Discovery in Posttraumatic Stress Disorder: Triangulating Genomic and Phenotypic Evidence from a Health System Biobank.
Lee YH, Zhang Y, Espinosa Dice AL, Li JH, Tubbs JD, Feng YA, Ge T, Maihofer AX, Nievergelt CM, Smoller JW, Koenen KC, Roberts AL, Slopen N. Lee YH, et al. Among authors: maihofer ax. medRxiv [Preprint]. 2025 Feb 28:2025.02.27.25322886. doi: 10.1101/2025.02.27.25322886. medRxiv. 2025. PMID: 40061358 Free PMC article. Preprint.
106 results