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Small-molecule dissolution of stress granules by redox modulation benefits ALS models.
Uechi H, Sridharan S, Nijssen J, Bilstein J, Iglesias-Artola JM, Kishigami S, Casablancas-Antras V, Poser I, Martinez EJ, Boczek E, Wagner M, Tomschke N, de Jesus Domingues AM, Pal A, Doeleman T, Kour S, Anderson EN, Stein F, Lee HO, Zhang X, Fritsch AW, Jahnel M, Fürsch J, Murthy AC, Alberti S, Bickle M, Fawzi NL, Nadler A, David DC, Pandey UB, Hermann A, Stengel F, Davis BG, Baldwin AJ, Savitski MM, Hyman AA, Wheeler RJ. Uechi H, et al. Among authors: murthy ac. Nat Chem Biol. 2025 Oct;21(10):1577-1588. doi: 10.1038/s41589-025-01893-5. Epub 2025 May 14. Nat Chem Biol. 2025. PMID: 40369342 Free PMC article.
Intrinsically disordered regions and RNA binding domains contribute to protein enrichment in biomolecular condensates in Xenopus oocytes.
O'Connell LC, Johnson V, Hutton AK, Otis JP, Murthy AC, Liang MC, Wang SH, Fawzi NL, Mowry KL. O'Connell LC, et al. Among authors: murthy ac. bioRxiv [Preprint]. 2023 Nov 10:2023.11.10.566489. doi: 10.1101/2023.11.10.566489. bioRxiv. 2023. Update in: Sci Rep. 2024 Nov 13;14(1):27890. doi: 10.1038/s41598-024-79409-9. PMID: 37986933 Free PMC article. Updated. Preprint.
SARS-CoV-2 nucleocapsid protein undergoes liquid-liquid phase separation stimulated by RNA and partitions into phases of human ribonucleoproteins.
Perdikari TM, Murthy AC, Ryan VH, Watters S, Naik MT, Fawzi NL. Perdikari TM, et al. Among authors: murthy ac. bioRxiv [Preprint]. 2020 Jun 10:2020.06.09.141101. doi: 10.1101/2020.06.09.141101. bioRxiv. 2020. Update in: EMBO J. 2020 Dec 15;39(24):e106478. doi: 10.15252/embj.2020106478. PMID: 32577653 Free PMC article. Updated. Preprint.
25 results