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Page 1
Nucleophosmin supports WNT-driven hyperproliferation and tumor initiation.
Kanellos G, Giacomelli C, Raven A, Vlahov N, Jin H, Herviou P, Malla SB, Nasreddin N, Centeno PP, Alexandrou C, Gilroy K, Baird RL, Pennel K, Munro J, Waldron JA, Hall H, Officer-Jones L, Bryson S, Strathdee D, Lilla S, Zanivan S, Morrison V, Nixon C, Ridgway RA, Miller C, Knight JRP, Campbell AD, Dunne PD, Le Quesne J, Edwards J, Park PJ, Bushell M, Sansom OJ. Kanellos G, et al. Among authors: bushell m. Nat Genet. 2025 Dec 18. doi: 10.1038/s41588-025-02408-7. Online ahead of print. Nat Genet. 2025. PMID: 41413654
Inhibiting translation elongation by reducing eIF5A activity induces feedback inhibition of initiation, limiting tumour cell proliferation.
Sfakianos AP, Raven RM, Smith T, Sun XM, Mulroney TE, Pizzinga M, Dezi V, Tenor AR, Stoneley M, Cole CH, Al-Doori K, Nur HA, Pennie RL, Powley I, Officer-Jones L, Sawarkar R, Turner M, MacFarlane M, Sansom OJ, Bushell M, Le Quesne J, Harvey RF, Willis AE. Sfakianos AP, et al. Among authors: bushell m. Nat Commun. 2025 Dec 13;16(1):11486. doi: 10.1038/s41467-025-66531-z. Nat Commun. 2025. PMID: 41390489 Free PMC article.
Hepatic zonation determines tumorigenic potential of mutant β-catenin.
Raven A, Gilroy K, Jin H, Waldron JA, Leslie H, Munro J, Hall H, Ridgway RA, Ford CA, Gulhan DC, Vlahov N, Mills ML, Hartley A, Anderson E, Bryson S, Sphyris N, Müller M, May S, Cadden B, Nixon C, Waddell SH, Guest R, Boulter L, Barker N, Clevers H, Zhu H, Ivaska J, Strathdee D, Miller CJ, Jamieson NB, Bushell M, Park PJ, Bird TG, Sansom OJ. Raven A, et al. Among authors: bushell m. Nature. 2025 Nov 19. doi: 10.1038/s41586-025-09733-1. Online ahead of print. Nature. 2025. PMID: 41261129
Retraction: Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes.
Powley IR, Kondrashov A, Young LA, Dobbyn HC, Hill K, Cannell IG, Stoneley M, Kong YW, Cotes JA, Smith GCM, Wek R, Hayes C, Gant TW, Spriggs KA, Bushell M, Willis AE. Powley IR, et al. Among authors: bushell m. Genes Dev. 2025 Jun 1;39(11-12):788. doi: 10.1101/gad.352836.125. Genes Dev. 2025. PMID: 40456593 Free PMC article. No abstract available.
Maintenance of p-eIF2α levels by the eIF2B complex is vital for colorectal cancer.
Škapik IP, Giacomelli C, Hahn S, Deinlein H, Gallant P, Diebold M, Biayna J, Hendricks A, Olimski L, Otto C, Kastner C, Wolf E, Schülein-Völk C, Maurus K, Rosenwald A, Schleussner N, Jackstadt RF, Schlegel N, Germer CT, Bushell M, Eilers M, Schmidt S, Wiegering A. Škapik IP, et al. Among authors: bushell m. EMBO J. 2025 Apr;44(7):2075-2105. doi: 10.1038/s44318-025-00381-9. Epub 2025 Feb 27. EMBO J. 2025. PMID: 40016419 Free PMC article.
195 results