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Ongoing replication stress tolerance and clonal T cell responses distinguish liver and lung recurrence and outcomes in pancreatic cancer.
Link JM, Eng JR, Pelz C, MacPherson-Hawthorne K, Worth PJ, Sivagnanam S, Keith DJ, Owen S, Langer EM, Grossblatt-Wait A, Salgado-Garza G, Creason AL, Protzek S, Egger J, Holly H, Heskett MB, Chin K, Kirchberger N, Betre K, Bucher E, Kilburn D, Hu Z, Munks MW, English IA, Tsuda M, Goecks J, Demir E, Adey AC, Kardosh A, Lopez CD, Sheppard BC, Guimaraes A, Brinkerhoff B, Morgan TK, Mills GB, Coussens LM, Brody JR, Sears RC. Link JM, et al. Among authors: sears rc. Nat Cancer. 2025 Jan;6(1):123-144. doi: 10.1038/s43018-024-00881-3. Epub 2025 Jan 9. Nat Cancer. 2025. PMID: 39789181 Free PMC article.
Tumor-Infiltrating Leukocyte Phenotypes Distinguish Outcomes in Related Patients With Pancreatic Adenocarcinoma.
Link JM, Liudahl SM, Betts CB, Sivagnanam S, Leis KR, McDonnell M, Pelz CR, Johnson B, Hamman KJ, Keith D, Sampson JE, Morgan TK, Lopez CD, Coussens LM, Sears RC. Link JM, et al. Among authors: sears rc. JCO Precis Oncol. 2021 Feb 5;5:PO.20.00287. doi: 10.1200/PO.20.00287. eCollection 2021. JCO Precis Oncol. 2021. PMID: 34036232 Free PMC article. No abstract available.
CASPER: A Phase I trial combining calaspargase pegol-mnkl and cobimetinib in pancreatic cancer.
Lopez CD, Kardosh A, Chen EY, Pegna G, Guimaraes A, Foster B, Brinkerhoff B, Goodyear SM, Lim JY, Taber E, Rajagopalan B, Edmerson E, Vo J, Nelson K, Jackson A, Gingerich T, Fahlman A, Lessenich C, Fennell F, Ventura D, Roy P, Keith D, Sheppard B, Brody JR, Mills GB, Ronai ZA, Sears RC. Lopez CD, et al. Among authors: sears rc. Future Oncol. 2024;20(37):2915-2925. doi: 10.1080/14796694.2024.2395235. Epub 2024 Oct 8. Future Oncol. 2024. PMID: 39378065
The polymeric fluoropyrimidine CF10 overcomes limitations of 5-FU in pancreatic ductal adenocarcinoma cells through increased replication stress.
Finan JM, Di Niro R, Park SY, Jeong KJ, Hedberg MD, Smith A, McCarthy GA, Haber AO, Muschler J, Sears RC, Mills GB, Gmeiner WH, Brody JR. Finan JM, et al. Among authors: sears rc. Cancer Biol Ther. 2024 Dec 31;25(1):2421584. doi: 10.1080/15384047.2024.2421584. Epub 2024 Nov 8. Cancer Biol Ther. 2024. PMID: 39513592 Free PMC article.
Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer.
Risom T, Langer EM, Chapman MP, Rantala J, Fields AJ, Boniface C, Alvarez MJ, Kendsersky ND, Pelz CR, Johnson-Camacho K, Dobrolecki LE, Chin K, Aswani AJ, Wang NJ, Califano A, Lewis MT, Tomlin CJ, Spellman PT, Adey A, Gray JW, Sears RC. Risom T, et al. Among authors: sears rc. Nat Commun. 2018 Sep 19;9(1):3815. doi: 10.1038/s41467-018-05729-w. Nat Commun. 2018. PMID: 30232459 Free PMC article.
MYC Deregulation and PTEN Loss Model Tumor and Stromal Heterogeneity of Aggressive Triple-Negative Breast Cancer.
Doha ZO, Wang X, Calistri NL, Eng J, Daniel CJ, Ternes L, Kim EN, Pelz C, Munks M, Betts C, Kwon S, Bucher E, Li X, Waugh T, Tatarova Z, Blumberg D, Ko A, Kirchberger N, Pietenpol JA, Sanders ME, Langer EM, Dai MS, Mills G, Chin K, Chang YH, Coussens LM, Gray JW, Heiser LM, Sears RC. Doha ZO, et al. Among authors: sears rc. Nat Commun. 2023 Sep 13;14(1):5665. doi: 10.1038/s41467-023-40841-6. Nat Commun. 2023. PMID: 37704631 Free PMC article.
138 results