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Page 1
Characterizing the quick-killing mechanism of action of azithromycin analogs against malaria parasites.
Mao EY, Nguyen W, Jana GP, Maity BC, Pazicky S, Giannangelo C, Reader J, Famodimu MT, Birkholtz L-M, Delves MJ, Creek DJ, Bozdech Z, Laleu B, Burrows JN, Sleebs BE, Gancheva MR, Wilson DW. Mao EY, et al. Antimicrob Agents Chemother. 2025 Sep 3;69(9):e0178324. doi: 10.1128/aac.01783-24. Epub 2025 Jul 25. Antimicrob Agents Chemother. 2025. PMID: 40711456 Free PMC article.
Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4.
Ashton TD, Calic PPS, Dans MG, Kang Ooi Z, Zhou Q, Loi K, Jarman KE, Palandri J, Qiu D, Lehane AM, Maity B, De N, Famodimu MT, Delves MJ, Mao EY, Gancheva MR, Wilson DW, Chowdury M, de Koning-Ward TF, Baud D, Brand S, Jackson PF, Cowman AF, Sleebs BE. Ashton TD, et al. Among authors: mao ey. ChemMedChem. 2024 Dec 16;19(24):e202400549. doi: 10.1002/cmdc.202400549. Epub 2024 Oct 29. ChemMedChem. 2024. PMID: 39210733 Free PMC article.
Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4.
Awalt JK, Ooi ZK, Ashton TD, Mansouri M, Calic PPS, Zhou Q, Vasanthan S, Lee S, Loi K, Jarman KE, Penington JS, Qiu D, Zhang X, Lehane AM, Mao EY, Gancheva MR, Wilson DW, Giannangelo C, MacRaild CA, Creek DJ, Yeo T, Sheth T, Fidock DA, Churchyard A, Baum J, Famodimu MT, Delves MJ, Kristan M, Stewart L, Sutherland CJ, Coyle R, Jagoe H, Lee MCS, Chowdury M, de Koning-Ward TF, Baud D, Brand S, Jackson PF, Cowman AF, Dans MG, Sleebs BE. Awalt JK, et al. Among authors: mao ey. J Med Chem. 2025 Apr 24;68(8):8933-8966. doi: 10.1021/acs.jmedchem.5c00614. Epub 2025 Apr 14. J Med Chem. 2025. PMID: 40228810 Free PMC article.
Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4.
Ashton TD, Calic PPS, Dans MG, Ooi ZK, Zhou Q, Palandri J, Loi K, Jarman KE, Qiu D, Lehane AM, Maity BC, De N, Giannangelo C, MacRaild CA, Creek DJ, Mao EY, Gancheva MR, Wilson DW, Chowdury M, de Koning-Ward TF, Famodimu MT, Delves MJ, Pollard H, Sutherland CJ, Baud D, Brand S, Jackson PF, Cowman AF, Sleebs BE. Ashton TD, et al. Among authors: mao ey. J Med Chem. 2024 Aug 22;67(16):14493-14523. doi: 10.1021/acs.jmedchem.4c01241. Epub 2024 Aug 12. J Med Chem. 2024. PMID: 39134060 Free PMC article.