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Development and application of a high-throughput screening assay for identification of small molecule inhibitors of the P. falciparum reticulocyte binding-like homologue 5 protein.
Sleebs BE, Jarman KE, Frolich S, Wong W, Healer J, Dai W, Lucet IS, Wilson DW, Cowman AF. Sleebs BE, et al. Among authors: wilson dw. Int J Parasitol Drugs Drug Resist. 2020 Dec;14:188-200. doi: 10.1016/j.ijpddr.2020.10.008. Epub 2020 Oct 29. Int J Parasitol Drugs Drug Resist. 2020. PMID: 33152623 Free PMC article.
Property activity refinement of 2-anilino 4-amino substituted quinazolines as antimalarials with fast acting asexual parasite activity.
Ashton TD, Ngo A, Favuzza P, Bullen HE, Gancheva MR, Romeo O, Parkyn Schneider M, Nguyen N, Steel RWJ, Duffy S, Lowes KN, Sabroux HJ, Avery VM, Boddey JA, Wilson DW, Cowman AF, Gilson PR, Sleebs BE. Ashton TD, et al. Among authors: wilson dw. Bioorg Chem. 2021 Dec;117:105359. doi: 10.1016/j.bioorg.2021.105359. Epub 2021 Sep 21. Bioorg Chem. 2021. PMID: 34689083
Targeting malaria parasites with novel derivatives of azithromycin.
Burns AL, Sleebs BE, Gancheva M, McLean KT, Siddiqui G, Venter H, Beeson JG, O'Handley R, Creek DJ, Ma S, Frölich S, Goodman CD, McFadden GI, Wilson DW. Burns AL, et al. Among authors: wilson dw. Front Cell Infect Microbiol. 2022 Nov 30;12:1063407. doi: 10.3389/fcimb.2022.1063407. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 36530422 Free PMC article.
Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics.
Dans MG, Piirainen H, Nguyen W, Khurana S, Mehra S, Razook Z, Geoghegan ND, Dawson AT, Das S, Parkyn Schneider M, Jonsdottir TK, Gabriela M, Gancheva MR, Tonkin CJ, Mollard V, Goodman CD, McFadden GI, Wilson DW, Rogers KL, Barry AE, Crabb BS, de Koning-Ward TF, Sleebs BE, Kursula I, Gilson PR. Dans MG, et al. Among authors: wilson dw. PLoS Biol. 2023 Apr 13;21(4):e3002066. doi: 10.1371/journal.pbio.3002066. eCollection 2023 Apr. PLoS Biol. 2023. PMID: 37053271 Free PMC article.
444 results