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Synthetic group A streptogramin antibiotics that overcome Vat resistance.
Li Q, Pellegrino J, Lee DJ, Tran AA, Chaires HA, Wang R, Park JE, Ji K, Chow D, Zhang N, Brilot AF, Biel JT, van Zundert G, Borrelli K, Shinabarger D, Wolfe C, Murray B, Jacobson MP, Mühle E, Chesneau O, Fraser JS, Seiple IB. Li Q, et al. Among authors: fraser js. Nature. 2020 Oct;586(7827):145-150. doi: 10.1038/s41586-020-2761-3. Epub 2020 Sep 23. Nature. 2020. PMID: 32968273 Free PMC article.
Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase.
Díaz RE, Ecker AK, Correy GJ, Asthana P, Young ID, Faust B, Thompson MC, Seiple IB, Van Dyken SJ, Locksley RM, Fraser JS. Díaz RE, et al. Among authors: fraser js. bioRxiv [Preprint]. 2024 Mar 25:2023.06.03.542675. doi: 10.1101/2023.06.03.542675. bioRxiv. 2024. Update in: Elife. 2024 Jun 17;12:RP89918. doi: 10.7554/eLife.89918. PMID: 37398339 Free PMC article. Updated. Preprint.
Distal mutations enhance catalysis in designed enzymes by facilitating substrate binding and product release.
Zarifi N, Asthana P, Doustmohammadi H, Klaus C, Sanchez J, Hunt SE, Rakotoharisoa RV, Osuna S, Fraser JS, Chica RA. Zarifi N, et al. Among authors: fraser js. bioRxiv [Preprint]. 2025 Feb 27:2025.02.21.639315. doi: 10.1101/2025.02.21.639315. bioRxiv. 2025. Update in: Nat Commun. 2025 Sep 30;16(1):8662. doi: 10.1038/s41467-025-63802-7. PMID: 40060566 Free PMC article. Updated. Preprint.
Diffuse X-ray scattering to model protein motions.
Wall ME, Adams PD, Fraser JS, Sauter NK. Wall ME, et al. Among authors: fraser js. Structure. 2014 Feb 4;22(2):182-4. doi: 10.1016/j.str.2014.01.002. Structure. 2014. PMID: 24507780 Free PMC article.
224 results