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Cardiac adaptation to endurance exercise training requires suppression of GDF15 via PGC-1α.
Khetarpal SA, Li H, Vitale T, Rhee J, Challa S, Castro C, Pabel S, Sun Y, Liu J, Bogoslavski D, Vargas-Castillo A, Smythers AL, Blackmore KA, Grauvogel L, Mittenbühler MJ, Khandekar MJ, Curtin C, Narvaez-Paliza JM, Wang C, Houstis NE, Sprenger HG, Jurgens SJ, Biddinger KJ, Kuznetsov A, Freeman R, Ellinor PT, Nahrendorf M, Paulo JA, Gygi SP, Dumesic PA, Asnani A, Aragam KG, Puigserver P, Roh JD, Spiegelman BM, Rosenzweig A. Khetarpal SA, et al. Among authors: gygi sp. Nat Cardiovasc Res. 2025 Oct;4(10):1277-1294. doi: 10.1038/s44161-025-00712-3. Epub 2025 Sep 24. Nat Cardiovasc Res. 2025. PMID: 40993371
Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation.
Mitchell W, Goeminne LJE, Tyshkovskiy A, Zhang S, Chen JY, Paulo JA, Pierce KA, Choy AH, Clish CB, Gygi SP, Gladyshev VN. Mitchell W, et al. Among authors: gygi sp. bioRxiv [Preprint]. 2023 Nov 27:2023.06.30.546730. doi: 10.1101/2023.06.30.546730. bioRxiv. 2023. Update in: Elife. 2024 Mar 22;12:RP90579. doi: 10.7554/eLife.90579. PMID: 37425825 Free PMC article. Updated. Preprint.
Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST.
Sprenger HG, Mittenbühler MJ, Sun Y, Van Vranken JG, Schindler S, Jayaraj A, Khetarpal SA, Vargas-Castillo A, Puszynska AM, Spinelli JB, Armani A, Kunchok T, Ryback B, Seo HS, Song K, Sebastian L, O'Young C, Braithwaite C, Dhe-Paganon S, Burger N, Mills EL, Gygi SP, Arthanari H, Chouchani ET, Sabatini DM, Spiegelman BM. Sprenger HG, et al. Among authors: gygi sp. bioRxiv [Preprint]. 2024 Apr 10:2024.04.10.588849. doi: 10.1101/2024.04.10.588849. bioRxiv. 2024. Update in: Cell Metab. 2025 Apr 01;37(4):857-869.e9. doi: 10.1016/j.cmet.2025.01.024. PMID: 38645260 Free PMC article. Updated. Preprint.
769 results