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Page 1
Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4.
Alicea Pauneto CDM, Riesenberg BP, Gandy EJ, Kennedy AS, Clutton GT, Hem JW, Hurst KE, Hunt EG, Green JM, Miller BC, Angus SP, Johnson GL, Esther RJ, Guerriero JL, Gao P, Soto-Pantoja DR, Ferris RL, Modliszewski JL, Coleman MF, Chung HK, Milner JJ, Moschos SJ, Wiseman RL, Thaxton JE. Alicea Pauneto CDM, et al. Among authors: modliszewski jl. Immunity. 2025 Oct 14;58(10):2489-2504.e8. doi: 10.1016/j.immuni.2025.09.003. Epub 2025 Sep 25. Immunity. 2025. PMID: 41005293 Free article.
Atlas-Guided Discovery of Transcription Factors for T Cell Programming.
Chung HK, Liu C, Battu A, Jambor AN, Pratt BM, Xie F, Riesenberg BP, Casillas E, Sun M, Landoni E, Li Y, Ye Q, Joo D, Green J, Syed Z, Brown NJ, Smith M, Ma S, Chick B, Tripple V, Tan S, Wang ZA, Wang J, Mcdonald B, He P, Yang Q, Chen T, Varanasi SK, LaPorte M, Mann TH, Chen D, Hoffmann F, Ho J, Modliszewski J, Williams A, Liu Y, Wang Z, Liu J, Gao Y, Hu Z, Cho UH, Liu L, Wang Y, Hargreaves DC, Dotti G, Savoldo B, Thaxton JE, Milner JJ, Wang W, Kaech SM. Chung HK, et al. bioRxiv [Preprint]. 2025 Nov 2:2023.01.03.522354. doi: 10.1101/2023.01.03.522354. bioRxiv. 2025. Update in: Nature. 2026 Feb 4. doi: 10.1038/s41586-025-09989-7. PMID: 36711632 Free PMC article. Updated. Preprint.
Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment.
Green WD, Gomez A, Plotkin AL, Pratt BM, Merritt EF, Mullins GN, Kren NP, Modliszewski JL, Zhabotynsky V, Woodcock MG, Green JM, Cannon G, Pipkin ME, Dotti G, Thaxton JE, Pylayeva-Gupta Y, Baldwin AS, Morris JP 4th, Stanley N, Milner JJ. Green WD, et al. Among authors: modliszewski jl. Immunity. 2025 Jul 8;58(7):1725-1741.e9. doi: 10.1016/j.immuni.2025.04.030. Epub 2025 May 26. Immunity. 2025. PMID: 40425012
Latent Regulatory Programs Generate Synthetic T Cell States with Enhanced Therapeutic Potential.
Pratt BM, Mullins GN, Brown N, Green WD, Modliszewski J, Xie F, van Rooyen L, Zhabotynsky V, Jambor AN, Cannon G, Green JM, Kennedy A, Alicea Paunto CDM, Shi H, Merritt E, Egawa T, Somasundaram A, Wang W, Thaxton JE, Dotti G, Chung HK, Milner JJ. Pratt BM, et al. bioRxiv [Preprint]. 2026 Jan 8:2026.01.07.698190. doi: 10.64898/2026.01.07.698190. bioRxiv. 2026. PMID: 41542560 Free PMC article. Preprint.
Atlas-guided discovery of transcription factors for T cell programming.
Chung HK, Liu C, Battu A, Jambor AN, Pratt BM, Xie F, Riesenberg BP, Casillas E, Sun M, Landoni E, Li Y, Ye Q, Joo D, Green J, Syed Z, Brown NJ, Smith M, Ma S, Tan S, Chick B, Tripple V, Wang ZA, Wang J, Mcdonald B, He P, Yang Q, Chen T, Varanasi SK, LaPorte M, Mann TH, Chen D, Hoffmann F, Ho J, Modliszewski J, Williams A, Liu Y, Wang Z, Liu J, Gao Y, Hu Z, Cho UH, Liu L, Wang Y, Hargreaves DC, Dotti G, Savoldo B, Thaxton JE, Milner JJ, Kaech SM, Wang W. Chung HK, et al. Nature. 2026 Feb 4. doi: 10.1038/s41586-025-09989-7. Online ahead of print. Nature. 2026. PMID: 41639465
Mapping DNA Methylation Signatures to Identify Epigenetic Variation Across Subcortical Regions of the Human Posttraumatic Stress Disorder Brain.
Li H, Liu Y, Shi Y, Wang J, Nguyen TP, Xie Y, Zheng W, Cheng Y, Cruz DA, Modliszewski JL, Terwilliger R, Sliby AN, Martínez-Magaña JJ, Montalvo-Ortiz JL, Roache JD, Averill LA, Young-McCaughan S, Shiroma PR, Huber BR, Lewis DA, Glausier J, Holtzheimer P, Friedman MJ, Zhang J, Peterson AL, Abdallah CG, Valizadeh A, Zhang X, Xu K, Krystal JH, Duman RS, Zhao H, Corcoran DL, Williamson DE, Girgenti MJ. Li H, et al. Among authors: modliszewski jl. Biol Psychiatry. 2025 Nov 3:S0006-3223(25)01581-1. doi: 10.1016/j.biopsych.2025.10.032. Online ahead of print. Biol Psychiatry. 2025. PMID: 41192574 Free PMC article.
Correction: An FGFR-p53 developmental signaling axis drives salivary cancer progression.
Musicant AM, Billington JMR, Damrauer JS, Modliszewski JL, Landau LJB, Tsai YH, Mehta JH, Powers J, Betancourt R, Sekhri R, Padilla RJ, Hernandez-Prera JC, Hayes DN, Hackman TG, Gokcumen O, Knox SM, Amelio AL. Musicant AM, et al. Among authors: modliszewski jl. Oncogene. 2025 Aug;44(32):2924. doi: 10.1038/s41388-025-03478-x. Oncogene. 2025. PMID: 40542202 No abstract available.
An FGFR-p53 developmental signaling axis drives salivary cancer progression.
Musicant AM, Billington JMR, Damrauer JS, Modliszewski JL, Landau LJB, Tsai YH, Mehta JH, Powers J, Betancourt R, Sekhri R, Padilla RJ, Hernandez-Prera JC, Hayes DN, Hackman TG, Gokcumen O, Knox SM, Amelio AL. Musicant AM, et al. Among authors: modliszewski jl. Oncogene. 2025 Aug;44(32):2876-2892. doi: 10.1038/s41388-025-03444-7. Epub 2025 Jun 2. Oncogene. 2025. PMID: 40456865 Free PMC article.
Tumor suppressors in Sox2-mediated lung cancers promote distinct cell-intrinsic and immunologic remodeling.
Sengottuvel N, Whately KM, Modliszewski JL, Sellers RS, Green WD, Gong W, Woods AT, Livingston EW, Fagan-Solis KD, Cannon G, Edatt L, Yuan H, Chack AC, Sanchez Y, Zhou K, Dawoud A, Green JM, Godfrey V, Milner JJ, Gupta GP, Pecot CV. Sengottuvel N, et al. Among authors: modliszewski jl. JCI Insight. 2025 May 6;10(12):e171364. doi: 10.1172/jci.insight.171364. eCollection 2025 Jun 23. JCI Insight. 2025. PMID: 40327401 Free PMC article.
37 results