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Design principles of the common Gly-X6-Gly membrane protein building block.
Golden K, Avarvarei C, Anderson CT, Holcomb M, Tang W, Dai X, Zhang M, Mailie CA, Sanchez BB, Chen JS, Forli S, Mravic M. Golden K, et al. Among authors: chen js. Proc Natl Acad Sci U S A. 2025 Oct 14;122(41):e2503134122. doi: 10.1073/pnas.2503134122. Epub 2025 Oct 7. Proc Natl Acad Sci U S A. 2025. PMID: 41055983
A Radical Approach to Anionic Chemistry: Synthesis of Ketones, Alcohols, and Amines.
Ni S, Padial NM, Kingston C, Vantourout JC, Schmitt DC, Edwards JT, Kruszyk MM, Merchant RR, Mykhailiuk PK, Sanchez BB, Yang S, Perry MA, Gallego GM, Mousseau JJ, Collins MR, Cherney RJ, Lebed PS, Chen JS, Qin T, Baran PS. Ni S, et al. Among authors: chen js. J Am Chem Soc. 2019 Apr 24;141(16):6726-6739. doi: 10.1021/jacs.9b02238. Epub 2019 Apr 16. J Am Chem Soc. 2019. PMID: 30943023 Free PMC article.
Expanding Reactivity in DNA-Encoded Library Synthesis via Reversible Binding of DNA to an Inert Quaternary Ammonium Support.
Flood DT, Asai S, Zhang X, Wang J, Yoon L, Adams ZC, Dillingham BC, Sanchez BB, Vantourout JC, Flanagan ME, Piotrowski DW, Richardson P, Green SA, Shenvi RA, Chen JS, Baran PS, Dawson PE. Flood DT, et al. Among authors: chen js. J Am Chem Soc. 2019 Jun 26;141(25):9998-10006. doi: 10.1021/jacs.9b03774. Epub 2019 Jun 12. J Am Chem Soc. 2019. PMID: 31136164 Free PMC article.
RASS-Enabled S/P-C and S-N Bond Formation for DEL Synthesis.
Flood DT, Zhang X, Fu X, Zhao Z, Asai S, Sanchez BB, Sturgell EJ, Vantourout JC, Richardson P, Flanagan ME, Piotrowski DW, Kölmel DK, Wan J, Tsai MH, Chen JS, Baran PS, Dawson PE. Flood DT, et al. Among authors: chen js. Angew Chem Int Ed Engl. 2020 May 4;59(19):7377-7383. doi: 10.1002/anie.201915493. Epub 2020 Mar 11. Angew Chem Int Ed Engl. 2020. PMID: 32050046 Free PMC article.
2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles.
Zambaldo C, Vinogradova EV, Qi X, Iaconelli J, Suciu RM, Koh M, Senkane K, Chadwick SR, Sanchez BB, Chen JS, Chatterjee AK, Liu P, Schultz PG, Cravatt BF, Bollong MJ. Zambaldo C, et al. Among authors: chen js. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29. J Am Chem Soc. 2020. PMID: 32302104 Free PMC article.
Synthetic Elaboration of Native DNA by RASS (SENDR).
Flood DT, Knouse KW, Vantourout JC, Kitamura S, Sanchez BB, Sturgell EJ, Chen JS, Wolan DW, Baran PS, Dawson PE. Flood DT, et al. Among authors: chen js. ACS Cent Sci. 2020 Oct 28;6(10):1789-1799. doi: 10.1021/acscentsci.0c00680. Epub 2020 Oct 5. ACS Cent Sci. 2020. PMID: 33145415 Free PMC article.
Selenomethionine as an expressible handle for bioconjugations.
Flood DT, Hintzen JCJ, Knouse KW, Hill DE, Lu C, Cistrone PA, Chen JS, Otomo T, Dawson PE. Flood DT, et al. Among authors: chen js. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2005164118. doi: 10.1073/pnas.2005164118. Proc Natl Acad Sci U S A. 2021. PMID: 33602807 Free PMC article.
3,230 results