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Page 1
Elucidating molecularly stratified single agent, and combination, therapeutic strategies targeting MCL1 for lethal prostate cancer.
Jiménez-Vacas JM, Westaby D, Figueiredo I, De Haven Brandon A, Padilha A, Yuan W, Seed G, Bogdan D, Gurel B, Bertan C, Miranda S, Lambros M, Montero-Hidalgo AJ, Coleman I, Yu IPL, Buroni L, Zeng W, Neeb AJ, Welti J, Rekowski J, Paravati R, Gabel F, Pandell N, Ferreira A, Crespo M, Riisnaes R, Das S, Taylor J, Waldron N, Hobern E, Valenti M, Ning J, Bernett I, Liodaki K, Persse T, Galipeau P, Wilkinson S, Trostel SY, Karzai F, Chau CH, Beatson EL, Zhang X, Klumpp-Thomas C, Varkaris A, Luque RM, Swain A, Raynaud F, Lack NA, Thomas CJ, Ha G, Figg WD, Bezzi M, Sowalsky AG, Nelson PS, Carreira S, Balk SP, de Bono JS, Sharp A. Jiménez-Vacas JM, et al. Among authors: klumpp thomas c. Nat Commun. 2025 Oct 8;16(1):8806. doi: 10.1038/s41467-025-64042-5. Nat Commun. 2025. PMID: 41062500 Free PMC article.
Systematic evaluation of Tox21 compounds that target β-adrenergic receptors and their role in cardiotoxicity.
Luo X, Zhang L, Sakamuru S, Adesina PA, Zhao J, Xia M, Xu T, Ngan DK, Travers J, Wood S, Sukhawanit R, Garrison A, Klumpp-Thomas C, Ferguson SS, Zhu H, Hall MD, Reif DM, Huang R. Luo X, et al. Among authors: klumpp thomas c. Toxicol Appl Pharmacol. 2025 Sep 14;505:117567. doi: 10.1016/j.taap.2025.117567. Online ahead of print. Toxicol Appl Pharmacol. 2025. PMID: 40957459 Free article.
Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7-Expressing CRPC Models.
Brim BC, Leon AF, Beatson EL, Kindrick JD, Bhadresha K, Zhang X, Napoli GC, Risdon EN, Schmidt KT, Wilson KM, McKnight C, Beck E, Klumpp-Thomas C, Ceribelli M, Yin J, Sowalsky AG, Price DK, Chau CH, Thomas CJ, Figg WD. Brim BC, et al. Among authors: klumpp thomas c. Cancer Res Commun. 2025 Aug 1;5(8):1396-1408. doi: 10.1158/2767-9764.CRC-25-0096. Cancer Res Commun. 2025. PMID: 40704654 Free PMC article.
Targeting of IRAK4 and GSPT1 enhances therapeutic efficacy in AML via c-Myc destabilization.
Vick EJ, Hassan A, Choi K, Bennett J, Muto T, Clough CA, Culver-Cochran AE, Hueneman K, Bolanos LC, Wunderlich M, Zhang X, McKnight C, Ceribelli M, Holland D, Klumpp-Thomas C, Greis KD, Thomas CJ, Starczynowski DT. Vick EJ, et al. Among authors: klumpp thomas c. Leukemia. 2025 Sep;39(9):2163-2173. doi: 10.1038/s41375-025-02695-3. Epub 2025 Jul 16. Leukemia. 2025. PMID: 40670672 Free PMC article.
AI-driven discovery of synergistic drug combinations against pancreatic cancer.
Pourmousa M, Jain S, Barnaeva E, Jin W, Hochuli J, Itkin Z, Maxfield T, Melo-Filho C, Thieme A, Wilson K, Klumpp-Thomas C, Michael S, Southall N, Jaakkola T, Muratov EN, Barzilay R, Tropsha A, Ferrer M, Zakharov AV. Pourmousa M, et al. Among authors: klumpp thomas c. Nat Commun. 2025 Apr 29;16(1):4020. doi: 10.1038/s41467-025-56818-6. Nat Commun. 2025. PMID: 40301300 Free PMC article.
Large-scale human myeloma cell line small molecule compound screen dataset.
Hughitt VK, Simmons JK, Gorjifard S, Michalowski A, Wilson K, Zhang X, Shinn P, Klumpp-Thomas C, McKnight C, Itkin Z, Chen L, Michael S, Keats J, Thomas C, Mock BA. Hughitt VK, et al. Among authors: klumpp thomas c. Sci Data. 2025 Apr 19;12(1):661. doi: 10.1038/s41597-025-04989-8. Sci Data. 2025. PMID: 40253396 Free PMC article.
Multi-Component, Time-Course screening to develop combination cancer therapies based on synergistic toxicity.
Ceribelli M, Tosto FA, Zhang X, Melani CJ, Roschewski M, Beck E, Klumpp-Thomas C, Peer CJ, Wilson KM, Chen L, McKnight C, Michael S, Itkin Z, Shinn P, Figg WD Sr, Wilson WH, Staudt LM, Thomas CJ. Ceribelli M, et al. Among authors: klumpp thomas c. Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2413372121. doi: 10.1073/pnas.2413372121. Epub 2024 Nov 25. Proc Natl Acad Sci U S A. 2024. PMID: 39585996 Free PMC article.
78 results