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155 results

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Page 1
Industrialization drives convergent microbial and physiological shifts in the human metaorganism.
Poyet M, Rühlemann M, Schaan AP, Ma Y, Moitinho-Silva L, Wacker EM, Jebens H, Patel L, Nguyen LTT, Zimmer A, Plichta D, McDonald D, Stevens C, Agyei A, Afihene MY, Asibey SO, Awuku YA, Badiane AS, Ching LS, Corzett C, Deme A, Dominguez-Rodrigo M, Duah A, Fezeu A, Froment A, Gibbons S, Girard C, Hooker J, Ibrahim F, Iqaluk D, Juimo V, Kettunen P, Lafosse S, Lango-Yaya E, Lehtimäki J, Lim YAL, Mabulla A, Mahachai V, Mohamed RS, Moniz K, Mwikarago IE, Nartey YA, Ndiaye D, Noel M, Onyekwere C, Pin TM, Plymoth A, Roberts L, Ruokolainen L, Rusine J, Segurel L, Shapiro BJ, Sigwazi S, Sistiaga A, Valles K, Vatanen T, Vilaichone RK, Rosenstiel P, Baines J, Franke A, Ellinghaus D, Knight R, Daly M, Xavier RJ, Alm EJ, Groussin M. Poyet M, et al. Among authors: ellinghaus d. bioRxiv [Preprint]. 2025 Oct 20:2025.10.20.683358. doi: 10.1101/2025.10.20.683358. bioRxiv. 2025. PMID: 41280098 Free PMC article. Preprint.
Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis.
Beaudoin M, Goyette P, Boucher G, Lo KS, Rivas MA, Stevens C, Alikashani A, Ladouceur M, Ellinghaus D, Törkvist L, Goel G, Lagacé C, Annese V, Bitton A, Begun J, Brant SR, Bresso F, Cho JH, Duerr RH, Halfvarson J, McGovern DP, Radford-Smith G, Schreiber S, Schumm PL, Sharma Y, Silverberg MS, Weersma RK; Quebec IBD Genetics Consortium; NIDDK IBD Genetics Consortium; International IBD Genetics Consortium; D'Amato M, Vermeire S, Franke A, Lettre G, Xavier RJ, Daly MJ, Rioux JD. Beaudoin M, et al. Among authors: d amato m, ellinghaus d. PLoS Genet. 2013;9(9):e1003723. doi: 10.1371/journal.pgen.1003723. Epub 2013 Sep 12. PLoS Genet. 2013. PMID: 24068945 Free PMC article.
Genetic liability to psoriasis predicts severe disease outcomes.
Saklatvala JR, Lessard S, Teder-Laving M, Thomas LF, Ramessur R, Zierer J, Åsvold BO, Barton A, Baudry D, Bowes J, Brumpton B, Bruno S, Chandran V, Chatelain C, de Rinaldis E, Elder JT, Ellinghaus D, Foerster J, Franke A, Gladman DD, Gulliver W, Hüffmeier U, Huilaja L, Hveem K, Khader S, Kingo K, Klinger K, Kolbinger F, Kõks S, Liao W, Nair RP, Nititham J, Rahman P, Reis A, Sagoo MK, Stuart PE, Tasanen K, Traks T, Tsoi LC, Uebe S, Watts K; BSTOP study group; Barker JN, Mahil SK, Langan SM; FinnGen; Estonian Biobank research team; Brown SJ, Løset M, Paternoster L, Dand N, Smith CH, Simpson MA. Saklatvala JR, et al. Among authors: ellinghaus d. Genome Med. 2025 Dec 17;18(1):14. doi: 10.1186/s13073-025-01561-2. Genome Med. 2025. PMID: 41408349 Free PMC article.
First insights into microbial changes within an Inflammatory Bowel Disease Family Cohort study.
Rausch P, Ratjen I, Tittmann L, Enderle J, Wacker EM, Jaeger K, Rühlemann MC, Franzpötter K, Ellul P, Kruse R, Halfvarson J, Roggenbuck D, Ellinghaus D, Jacobs G, Krawczak M, Schreiber S, Bang C, Lieb W, Franke A. Rausch P, et al. Among authors: ellinghaus d. Gut Microbes. 2025 Dec;17(1):2559119. doi: 10.1080/19490976.2025.2559119. Epub 2025 Oct 5. Gut Microbes. 2025. PMID: 41047557 Free PMC article.
Genome-wide association study of long COVID.
Lammi V, Nakanishi T, Jones SE, Andrews SJ, Karjalainen J, Cortés B, O'Brien HE, Ochoa-Guzman A, Fulton-Howard BE, Broberg M, Haapaniemi HH, Kanai M, Pirinen M, Schmidt A, Mitchell RE, Mousas A, Mangino M, Huerta-Chagoya A, Sinnott-Armstrong N, Cirulli ET, Vaudel M, Kwong ASF, Maiti AK, Marttila MM, Posner DC, Rodriguez AA, Batini C, Minnai F, Dearman AR, Warmerdam CAR, Sequeros CB, Winkler TW, Jordan DM, Rešcenko R, Miano L, Lane JM, Chung RK, Guillen-Guio B, Leavy OC, Carvajal-Silva L, Aguilar-Valdés K, Frangione E, Guare L, Vergasova E, Marouli E, Striano P, Zainulabid UA, Kumar A, Ahmad HF, Edahiro R, Azekawa S; Long COVID Host Genetics Initiative; FinnGen; VA Million Veteran Program; MexGen-COVID Initiative; DBDS Genomic Consortium; GEN-COVID Multicenter Study; PHOSP-COVID Collaborative Group; GENCOV Study; Estonian Biobank Research Team; Luoh SW, Erikstrup C, Pedersen OBV, Lerner-Ellis J, Colombo A, Grzymski JJ, Ishii M, Okada Y, Beckmann ND, Kumari M, Wagner R, Heid IM, John C, Short PJ, Magnus P, Ansone L, Valenti LVC, Lee SA, Wain LV, Verdugo RA, Banasik K, Geller F, Franke LH, Rakitko A, Duncan EL, Renieri A, Tsilidis KK, de Cid R, Niavarani A, Abner E, Tusié-Luna T, Ver… See abstract for full author list ➔ Lammi V, et al. Nat Genet. 2025 Jun;57(6):1402-1417. doi: 10.1038/s41588-025-02100-w. Epub 2025 May 21. Nat Genet. 2025. PMID: 40399555 Free PMC article.
Genome-wide association study of post COVID-19 syndrome in a population-based cohort in Germany.
Ruß AK, Schreiber S, Lieb W, Vehreschild JJ, Heuschmann PU, Illig T, Appel KS, Vehreschild MJGT, Krefting D, Reinke L, Viebke A, Poick S, Störk S, Reese JP, Zoller T, Krist L, Ellinghaus D, Foesel BU, Gieger C, Lorenz-Depiereux B, Witzenrath M, Anton G, Krawczak M, Heyckendorf J, Bahmer T. Ruß AK, et al. Among authors: ellinghaus d. Sci Rep. 2025 May 6;15(1):15791. doi: 10.1038/s41598-025-00945-z. Sci Rep. 2025. PMID: 40328884 Free PMC article.
GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets.
Dand N, Stuart PE, Bowes J, Ellinghaus D, Nititham J, Saklatvala JR, Teder-Laving M, Thomas LF, Traks T, Uebe S, Assmann G, Baudry D, Behrens F, Billi AC, Brown MA, Burkhardt H, Capon F, Chung R, Curtis CJ, Duckworth M, Ellinghaus E, FitzGerald O, Gerdes S, Griffiths CEM, Gulliver S, Helliwell PS, Ho P, Hoffmann P, Holmen OL, Huang ZM, Hveem K, Jadon D, Köhm M, Kraus C, Lamacchia C, Lee SH, Ma F, Mahil SK, McHugh N, McManus R, Modalsli EH, Nissen MJ, Nöthen M, Oji V, Oksenberg JR, Patrick MT, Perez White BE, Ramming A, Rech J, Rosen C, Sarkar MK, Schett G, Schmidt B, Tejasvi T, Traupe H, Voorhees JJ, Wacker EM, Warren RB, Wasikowski R, Weidinger S, Wen X, Zhang Z; BSTOP study group; Estonian Biobank research team; Barton A, Chandran V, Esko T, Foerster J, Franke A, Gladman DD, Gudjonsson JE, Gulliver W, Hüffmeier U, Kingo K, Kõks S, Liao W, Løset M, Mägi R, Nair RP, Rahman P, Reis A, Smith CH, Di Meglio P, Barker JN, Tsoi LC, Simpson MA, Elder JT. Dand N, et al. Among authors: ellinghaus d. Nat Commun. 2025 Feb 28;16(1):2051. doi: 10.1038/s41467-025-56719-8. Nat Commun. 2025. PMID: 40021644 Free PMC article.
Neolithic introgression of IL23R-related protection against chronic inflammatory bowel diseases in modern Europeans.
Krause-Kyora B, da Silva NA, Kaplan E, Kolbe D; Archaeological Civilization Disease Consortium (ACDC); Wohlers I, Busch H, Ellinghaus D, Caliebe A, Sezgin E, Nebel A, Schreiber S. Krause-Kyora B, et al. Among authors: ellinghaus d. EBioMedicine. 2025 Mar;113:105591. doi: 10.1016/j.ebiom.2025.105591. Epub 2025 Feb 8. EBioMedicine. 2025. PMID: 39923740 Free PMC article.
Defective Atg16l1 in intestinal epithelial cells links to altered fecal microbiota and metabolic shifts during pregnancy in mice.
López-Agudelo VA, Falk-Paulsen M, Bharti R, Rehman A, Sommer F, Wacker EM, Ellinghaus D, Luzius A, Sievers LK, Liebeke M, Kaser A, Rosenstiel P. López-Agudelo VA, et al. Among authors: ellinghaus d. Gut Microbes. 2024 Jan-Dec;16(1):2429267. doi: 10.1080/19490976.2024.2429267. Epub 2024 Dec 2. Gut Microbes. 2024. PMID: 39620359 Free PMC article.
155 results