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Page 1
Industrialization drives convergent microbial and physiological shifts in the human metaorganism.
Poyet M, Rühlemann M, Schaan AP, Ma Y, Moitinho-Silva L, Wacker EM, Jebens H, Patel L, Nguyen LTT, Zimmer A, Plichta D, McDonald D, Stevens C, Agyei A, Afihene MY, Asibey SO, Awuku YA, Badiane AS, Ching LS, Corzett C, Deme A, Dominguez-Rodrigo M, Duah A, Fezeu A, Froment A, Gibbons S, Girard C, Hooker J, Ibrahim F, Iqaluk D, Juimo V, Kettunen P, Lafosse S, Lango-Yaya E, Lehtimäki J, Lim YAL, Mabulla A, Mahachai V, Mohamed RS, Moniz K, Mwikarago IE, Nartey YA, Ndiaye D, Noel M, Onyekwere C, Pin TM, Plymoth A, Roberts L, Ruokolainen L, Rusine J, Segurel L, Shapiro BJ, Sigwazi S, Sistiaga A, Valles K, Vatanen T, Vilaichone RK, Rosenstiel P, Baines J, Franke A, Ellinghaus D, Knight R, Daly M, Xavier RJ, Alm EJ, Groussin M. Poyet M, et al. Among authors: kettunen p. bioRxiv [Preprint]. 2025 Oct 20:2025.10.20.683358. doi: 10.1101/2025.10.20.683358. bioRxiv. 2025. PMID: 41280098 Free PMC article. Preprint.
SARS-CoV-2 infection in hiPSC-derived neurons is cathepsin-dependent and causes differential accumulation of HIF1ɑ and phosphorylated tau.
Kettunen P, Ruuska J, Quirin T, Ojha R, Saber SH, Sng JDJ, Morrison S, Al-Mhanawi B, Shaker MR, De Neck S, Kipar A, Paavolainen L, Wolvetang E, Joensuu M, Koistinaho J, Rolova T, Balistreri G. Kettunen P, et al. Mol Ther Nucleic Acids. 2025 Sep 30;36(4):102726. doi: 10.1016/j.omtn.2025.102726. eCollection 2025 Dec 9. Mol Ther Nucleic Acids. 2025. PMID: 41216428 Free PMC article.
Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype.
Hellén M, Weert I, Müller SA, Räsänen N, Kettunen P, Lehtonen Š, Peitz M, Fließbach K, Takalo M, Koskuvi M, Lichtenthaler SF, Leinonen V, Ramirez A, Kärkkäinen O, Hiltunen M, Koistinaho J, Rõlova T. Hellén M, et al. Among authors: kettunen p. J Neuroinflammation. 2025 Jun 2;22(1):147. doi: 10.1186/s12974-025-03470-y. J Neuroinflammation. 2025. PMID: 40457456 Free PMC article.
Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes.
Wu YC, Lehtonen Š, Trontti K, Kauppinen R, Kettunen P, Leinonen V, Laakso M, Kuusisto J, Hiltunen M, Hovatta I, Freude K, Dhungana H, Koistinaho J, Rolova T. Wu YC, et al. Among authors: kettunen p. Fluids Barriers CNS. 2024 Sep 27;21(1):78. doi: 10.1186/s12987-024-00576-y. Fluids Barriers CNS. 2024. PMID: 39334385 Free PMC article.
Comparison of Patient Health Questionnaire-9, Edinburgh Postnatal Depression Scale and Hospital Anxiety and Depression - Depression subscale scores by administration mode: An individual participant data differential item functioning meta-analysis.
Harel D, Wu Y, Levis B, Fan S, Sun Y, Xu M, Rice DB, Boruff J, Markham S, Ioannidis JPA, Takwoingi Y, Patten SB, Ziegelstein RC, Cuijpers P, Gilbody S, Vigod S, Akena D, Benedetti A, Thombs BD; DEPRESsion Screening Data (DEPRESSD) Collaboration. Harel D, et al. J Affect Disord. 2024 Sep 15;361:674-683. doi: 10.1016/j.jad.2024.06.033. Epub 2024 Jun 21. J Affect Disord. 2024. PMID: 38908554
159 results