Howells AJ - Search Results

1

The 43-kilodalton N-terminal fragment of the DNA gyrase B protein hydrolyzes ATP and binds coumarin drugs.

Ali JA, Jackson AP, Howells AJ, Maxwell A. Ali JA, et al. Among authors: howells aj. Biochemistry. 1993 Mar 16;32(10):2717-24. doi: 10.1021/bi00061a033. Biochemistry. 1993. PMID: 8383523

2

The interaction of DNA gyrase with the bacterial toxin CcdB: evidence for the existence of two gyrase-CcdB complexes.

Kampranis SC, Howells AJ, Maxwell A. Kampranis SC, et al. Among authors: howells aj. J Mol Biol. 1999 Oct 29;293(3):733-44. doi: 10.1006/jmbi.1999.3182. J Mol Biol. 1999. PMID: 10543963

3

Locking the ATP-operated clamp of DNA gyrase: probing the mechanism of strand passage.

Williams NL, Howells AJ, Maxwell A. Williams NL, et al. Among authors: howells aj. J Mol Biol. 2001 Mar 9;306(5):969-84. doi: 10.1006/jmbi.2001.4468. J Mol Biol. 2001. PMID: 11237612

4

Overexpression and purification of bacterial DNA gyrase.

Maxwell A, Howells AJ. Maxwell A, et al. Among authors: howells aj. Methods Mol Biol. 1999;94:135-44. doi: 10.1385/1-59259-259-7:135. Methods Mol Biol. 1999. PMID: 12844869 No abstract available.

5

The interaction of the F plasmid killer protein, CcdB, with DNA gyrase: induction of DNA cleavage and blocking of transcription.

Critchlow SE, O'Dea MH, Howells AJ, Couturier M, Gellert M, Maxwell A. Critchlow SE, et al. Among authors: howells aj. J Mol Biol. 1997 Nov 7;273(4):826-39. doi: 10.1006/jmbi.1997.1357. J Mol Biol. 1997. PMID: 9367775

6

Discovery of a Novel DNA Gyrase-Targeting Antibiotic through the Chemical Perturbation of Streptomyces venezuelae Sporulation.

McAuley S, Huynh A, Howells A, Walpole C, Maxwell A, Nodwell JR. McAuley S, et al. Cell Chem Biol. 2019 Sep 19;26(9):1274-1282.e4. doi: 10.1016/j.chembiol.2019.06.002. Epub 2019 Jul 3. Cell Chem Biol. 2019. PMID: 31279606 Free PMC article.

7

Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action.

Flatman RH, Howells AJ, Heide L, Fiedler HP, Maxwell A. Flatman RH, et al. Among authors: howells aj. Antimicrob Agents Chemother. 2005 Mar;49(3):1093-100. doi: 10.1128/AAC.49.3.1093-1100.2005. Antimicrob Agents Chemother. 2005. PMID: 15728908 Free PMC article.

8

Ciprofloxacin affects conformational equilibria of DNA gyrase A in the presence of magnesium ions.

Sissi C, Perdonà E, Domenici E, Feriani A, Howells AJ, Maxwell A, Palumbo M. Sissi C, et al. Among authors: howells aj. J Mol Biol. 2001 Aug 3;311(1):195-203. doi: 10.1006/jmbi.2001.4838. J Mol Biol. 2001. PMID: 11469868

9

A biochemical analysis of the interaction of DNA gyrase with the bacteriophage Mu, pSC101 and pBR322 strong gyrase sites: the role of DNA sequence in modulating gyrase supercoiling and biological activity.

Oram M, Howells AJ, Maxwell A, Pato ML. Oram M, et al. Among authors: howells aj. Mol Microbiol. 2003 Oct;50(1):333-47. doi: 10.1046/j.1365-2958.2003.03690.x. Mol Microbiol. 2003. PMID: 14507384 Free article.

10

Clerocidin, a terpenoid antibiotic, inhibits bacterial DNA gyrase.

McCullough JE, Muller MT, Howells AJ, Maxwell A, O'Sullivan J, Summerill RS, Parker WL, Wells JS, Bonner DP, Fernandes PB. McCullough JE, et al. Among authors: howells aj. J Antibiot (Tokyo). 1993 Mar;46(3):526-30. doi: 10.7164/antibiotics.46.526. J Antibiot (Tokyo). 1993. PMID: 8386713 Free article. No abstract available.

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