Duch DS - Search Results

1

Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase.

Duch DS, Banks S, Dev IK, Dickerson SH, Ferone R, Heath LS, Humphreys J, Knick V, Pendergast W, Singer S, et al. Duch DS, et al. Cancer Res. 1993 Feb 15;53(4):810-8. Cancer Res. 1993. PMID: 8428362

2

Metabolic effects and kill of human T-cell leukemia by 5-deazaacyclotetrahydrofolate, a specific inhibitor of glycineamide ribonucleotide transformylase.

Smith GK, Duch DS, Dev IK, Kaufmann SH. Smith GK, et al. Among authors: duch ds. Cancer Res. 1992 Sep 15;52(18):4895-903. Cancer Res. 1992. PMID: 1516046

3

Benzo[f]quinazoline inhibitors of thymidylate synthase: methyleneamino-linked aroylglutamate derivatives.

Pendergast W, Dickerson SH, Dev IK, Ferone R, Duch DS, Smith GK. Pendergast W, et al. Among authors: duch ds. J Med Chem. 1994 Mar 18;37(6):838-44. doi: 10.1021/jm00032a019. J Med Chem. 1994. PMID: 8145235

4

Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some sulfonamidobenzoylglutamate and related derivatives.

Pendergast W, Dickerson SH, Johnson JV, Dev IK, Ferone R, Duch DS, Smith GK. Pendergast W, et al. Among authors: duch ds. J Med Chem. 1993 Oct 29;36(22):3464-71. doi: 10.1021/jm00074a030. J Med Chem. 1993. PMID: 8230138

5

Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some 3-amino- and 3-methylbenzo[f]quinazolin-1(2H)-ones.

Pendergast W, Johnson JV, Dickerson SH, Dev IK, Duch DS, Ferone R, Hall WR, Humphreys J, Kelly JM, Wilson DC. Pendergast W, et al. Among authors: duch ds. J Med Chem. 1993 Aug 6;36(16):2279-91. doi: 10.1021/jm00068a004. J Med Chem. 1993. PMID: 8360872

6

Enhanced antitumor activity for the thymidylate synthase inhibitor 1843U89 through decreased host toxicity with oral folic acid.

Smith GK, Amyx H, Boytos CM, Duch DS, Ferone R, Wilson HR. Smith GK, et al. Among authors: duch ds. Cancer Res. 1995 Dec 15;55(24):6117-25. Cancer Res. 1995. PMID: 8521402

7

In vivo antitumor activity and metabolism of a series of 5-deazaacyclotetrahydrofolate (5-DACTHF) analogues.

Mullin RJ, Keith BR, Bigham EC, Duch DS, Ferone R, Heath LS, Singer S, Waters KA, Wilson HR. Mullin RJ, et al. Among authors: duch ds. Biochem Pharmacol. 1992 Apr 1;43(7):1627-34. doi: 10.1016/0006-2952(92)90222-5. Biochem Pharmacol. 1992. PMID: 1567484

8

Synthesis and biological activity of open-chain analogues of 5,6,7,8-tetrahydrofolic acid--potential antitumor agents.

Bigham EC, Hodson SJ, Mallory WR, Wilson D, Duch DS, Smith GK, Ferone R. Bigham EC, et al. Among authors: duch ds. J Med Chem. 1992 Apr 17;35(8):1399-410. doi: 10.1021/jm00086a008. J Med Chem. 1992. PMID: 1573633

9

Synthesis and biological evaluation of 5-deazaisofolic acid, 5-deaza-5,6,7,8-tetrahydroisofolic acid, and their N9-substituted analogues.

Singh SK, Dev IK, Duch DS, Ferone R, Smith GK, Freisheim JH, Hynes JB. Singh SK, et al. Among authors: duch ds. J Med Chem. 1991 Feb;34(2):606-10. doi: 10.1021/jm00106a021. J Med Chem. 1991. PMID: 1995883

10

Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid.

Kelley JL, McLean EW, Cohn NK, Edelstein MP, Duch DS, Smith GK, Hanlon MH, Ferone R. Kelley JL, et al. Among authors: duch ds. J Med Chem. 1990 Feb;33(2):561-7. doi: 10.1021/jm00164a014. J Med Chem. 1990. PMID: 2299624

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