Hruby VJ - Search Results

1

The role of phenylalanine at position 6 in glucagon's mechanism of biological action: multiple replacement analogues of glucagon.

Azizeh BY, Ahn JM, Caspari R, Shenderovich MD, Trivedi D, Hruby VJ. Azizeh BY, et al. Among authors: hruby vj. J Med Chem. 1997 Aug 1;40(16):2555-62. doi: 10.1021/jm960800d. J Med Chem. 1997. PMID: 9258362

2

Structure-activity relationships of gamma-MSH analogues at the human melanocortin MC3, MC4, and MC5 receptors. Discovery of highly selective hMC3R, hMC4R, and hMC5R analogues.

Balse-Srinivasan P, Grieco P, Cai M, Trivedi D, Hruby VJ. Balse-Srinivasan P, et al. Among authors: hruby vj. J Med Chem. 2003 Nov 6;46(23):4965-73. doi: 10.1021/jm030119t. J Med Chem. 2003. PMID: 14584947

3

Novel 3D pharmacophore of alpha-MSH/gamma-MSH hybrids leads to selective human MC1R and MC3R analogues.

Cai M, Mayorov AV, Cabello C, Stankova M, Trivedi D, Hruby VJ. Cai M, et al. Among authors: hruby vj. J Med Chem. 2005 Mar 24;48(6):1839-48. doi: 10.1021/jm049579s. J Med Chem. 2005. PMID: 15771429

4

Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities.

Mayorov AV, Cai M, Chandler KB, Petrov RR, Van Scoy AR, Yu Z, Tanaka DK, Trivedi D, Hruby VJ. Mayorov AV, et al. Among authors: hruby vj. J Med Chem. 2006 Mar 23;49(6):1946-52. doi: 10.1021/jm0510326. J Med Chem. 2006. PMID: 16539382 Free PMC article.

5

Design, synthesis, and biological evaluation of new cyclic melanotropin peptide analogues selective for the human melanocortin-4 receptor.

Ying J, Gu X, Cai M, Dedek M, Vagner J, Trivedi DB, Hruby VJ. Ying J, et al. Among authors: hruby vj. J Med Chem. 2006 Nov 16;49(23):6888-96. doi: 10.1021/jm060768f. J Med Chem. 2006. PMID: 17154518 Free PMC article.

6

Design and microwave-assisted synthesis of novel macrocyclic peptides active at melanocortin receptors: discovery of potent and selective hMC5R receptor antagonists.

Grieco P, Cai M, Liu L, Mayorov A, Chandler K, Trivedi D, Lin G, Campiglia P, Novellino E, Hruby VJ. Grieco P, et al. Among authors: hruby vj. J Med Chem. 2008 May 8;51(9):2701-7. doi: 10.1021/jm701181n. Epub 2008 Apr 15. J Med Chem. 2008. PMID: 18412316 Free PMC article.

7

Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor.

Qu H, Cai M, Mayorov AV, Grieco P, Zingsheim M, Trivedi D, Hruby VJ. Qu H, et al. Among authors: hruby vj. J Med Chem. 2009 Jun 25;52(12):3627-35. doi: 10.1021/jm801300c. J Med Chem. 2009. PMID: 19473029 Free PMC article.

8

Novel cyclic templates of alpha-MSH give highly selective and potent antagonists/agonists for human melanocortin-3/4 receptors.

Kavarana MJ, Trivedi D, Cai M, Ying J, Hammer M, Cabello C, Grieco P, Han G, Hruby VJ. Kavarana MJ, et al. Among authors: hruby vj. J Med Chem. 2002 Jun 6;45(12):2644-50. doi: 10.1021/jm020021z. J Med Chem. 2002. PMID: 12036373

9

Structure-activity studies of the melanocortin peptides: discovery of potent and selective affinity antagonists for the hMC3 and hMC4 receptors.

Grieco P, Lavecchia A, Cai M, Trivedi D, Weinberg D, MacNeil T, Van der Ploeg LH, Hruby VJ. Grieco P, et al. Among authors: hruby vj. J Med Chem. 2002 Nov 21;45(24):5287-94. doi: 10.1021/jm0202526. J Med Chem. 2002. PMID: 12431055

10

Synthetic glucagon antagonists and partial agonists.

Zechel C, Trivedi D, Hruby VJ. Zechel C, et al. Among authors: hruby vj. Int J Pept Protein Res. 1991 Aug;38(2):131-8. doi: 10.1111/j.1399-3011.1991.tb01420.x. Int J Pept Protein Res. 1991. PMID: 1664420

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