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Folic acid-enhanced synergy for the combination of trimetrexate plus the glycinamide ribonucleotide formyltransferase inhibitor 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5,4,6][1,4]thiazin -6-yl)-(S)-ethyl]-2,5-thienoylamino-L-glutamic acid (AG2034): comparison across sensitive and resistant human tumor cell lines.
Faessel HM, Slocum HK, Rustum YM, Greco WR. Faessel HM, et al. Among authors: rustum ym. Biochem Pharmacol. 1999 Mar 1;57(5):567-77. doi: 10.1016/s0006-2952(98)00315-3. Biochem Pharmacol. 1999. PMID: 9952321
Lack of microvessels in well-differentiated regions of human head and neck squamous cell carcinoma A253 associated with functional magnetic resonance imaging detectable hypoxia, limited drug delivery, and resistance to irinotecan therapy.
Bhattacharya A, Tóth K, Mazurchuk R, Spernyak JA, Slocum HK, Pendyala L, Azrak R, Cao S, Durrani FA, Rustum YM. Bhattacharya A, et al. Among authors: rustum ym. Clin Cancer Res. 2004 Dec 1;10(23):8005-17. doi: 10.1158/1078-0432.CCR-04-1306. Clin Cancer Res. 2004. PMID: 15585636
311 results