Physical and immunogenic stability of spray freeze-dried influenza vaccine powder for pulmonary delivery: comparison of inulin, dextran, or a mixture of dextran and trehalose as protectants.
Murugappan S, Patil HP, Kanojia G, ter Veer W, Meijerhof T, Frijlink HW, Huckriede A, Hinrichs WL.
Murugappan S, et al.
Eur J Pharm Biopharm. 2013 Nov;85(3 Pt A):716-25. doi: 10.1016/j.ejpb.2013.07.018. Epub 2013 Aug 8.
Eur J Pharm Biopharm. 2013.
PMID: 23933147
Frijlink, Pulmonary delivery of an inulin-stabilized influenza subunit vaccine prepared by spray-freeze drying induces systemic, mucosal humoral as well as cell-mediated immune responses in BALB/c mice, Vaccine 25 (2007) 8707-8717; S.A. Audouy, G. van der Schaaf, W.L.J. Hi …
Frijlink, Pulmonary delivery of an inulin-stabilized influenza subunit vaccine prepared by spray-freeze drying induces systemic, mucosal hum …