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Year Number of Results
1863 1
1886 1
1895 1
1897 1
1899 1
1901 2
1903 1
1909 1
1910 1
1911 3
1912 1
1914 2
1915 3
1916 2
1917 4
1918 2
1919 3
1920 2
1921 1
1922 1
1923 5
1924 3
1925 6
1926 6
1927 4
1928 5
1929 4
1930 3
1931 3
1932 3
1934 9
1935 7
1936 8
1937 12
1938 10
1939 7
1940 6
1941 8
1942 8
1943 1
1944 10
1945 45
1946 176
1947 214
1948 268
1949 173
1950 234
1951 238
1952 277
1953 334
1954 333
1955 355
1956 359
1957 383
1958 430
1959 458
1960 521
1961 618
1962 666
1963 784
1964 1136
1965 1153
1966 1249
1967 1501
1968 1758
1969 1858
1970 1971
1971 1833
1972 1721
1973 2252
1974 2528
1975 4841
1976 5319
1977 5119
1978 5448
1979 6524
1980 7546
1981 8231
1982 9322
1983 10555
1984 11439
1985 12120
1986 12434
1987 13248
1988 14404
1989 16176
1990 17766
1991 18814
1992 20316
1993 20905
1994 22477
1995 23825
1996 24437
1997 23486
1998 23003
1999 23795
2000 25911
2001 27492
2002 28173
2003 29510
2004 31344
2005 32443
2006 34150
2007 35561
2008 37042
2009 37586
2010 40218
2011 43030
2012 45856
2013 47585
2014 48878
2015 49285
2016 50013
2017 51553
2018 53055
2019 55481
2020 60484
2021 64161
2022 63214
2023 59770
2024 63665
2025 51939
2026 58

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1,427,054 results

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Page 1
An Extensive Review on beta-lactamase Enzymes and their Inhibitors.
Agarwal V, Tiwari A, Varadwaj P. Agarwal V, et al. Curr Med Chem. 2023;30(7):783-808. doi: 10.2174/0929867329666220620165429. Curr Med Chem. 2023. PMID: 35726414 Review.
beta-lactam antibiotics treat bacterial infections very effectively, but overuse and misuse have led to resistance. beta-lactamase enzymes hydrolyze beta-lactam antibiotics and are the primary cause of resistance in bacteria. ...Such mutations and structural …
beta-lactam antibiotics treat bacterial infections very effectively, but overuse and misuse have led to resistance. beta-lacta …
Metallo-beta-lactamase inhibitors: A continuing challenge for combating antibiotic resistance.
Kang SJ, Kim DH, Lee BJ. Kang SJ, et al. Biophys Chem. 2024 Jun;309:107228. doi: 10.1016/j.bpc.2024.107228. Epub 2024 Mar 25. Biophys Chem. 2024. PMID: 38552402 Review.
The expression of beta-lactamase enzymes produced by pathogens, which hydrolyze the amide bond of the beta-lactam ring, is the major mechanism for bacterial resistance to beta-lactams. ...To combat beta-lactamase-mediated resistance, great efforts have …
The expression of beta-lactamase enzymes produced by pathogens, which hydrolyze the amide bond of the beta-lactam ring, is the …
Progress toward inhibitors of metallo-beta-lactamases.
McGeary RP, Tan DT, Schenk G. McGeary RP, et al. Future Med Chem. 2017 May;9(7):673-691. doi: 10.4155/fmc-2017-0007. Epub 2017 May 15. Future Med Chem. 2017. PMID: 28504895 Review.
The global overuse of antibiotics has led to the emergence of drug-resistant pathogenic bacteria. Bacteria can combat beta-lactams by expressing beta-lactamases. Inhibitors of one class of beta-lactamase, the serine-beta-lactamases, are used clinically …
The global overuse of antibiotics has led to the emergence of drug-resistant pathogenic bacteria. Bacteria can combat beta-lactams by …
Beta-lactamases and beta-lactamase inhibitors.
Williams JD. Williams JD. Int J Antimicrob Agents. 1999 Aug;12 Suppl 1:S3-7; discussion S26-7. doi: 10.1016/s0924-8579(99)00085-0. Int J Antimicrob Agents. 1999. PMID: 10526867 Review.
Resistance to beta-lactams mediated by beta-lactamases can be overcome successfully with the use of beta-lactamase inhibitors. The combination of beta-lactams with beta-lactamase inhibitors restores the activity of the beta-lactams, allow …
Resistance to beta-lactams mediated by beta-lactamases can be overcome successfully with the use of beta-lactamase inhi …
Beta 3-adrenoceptors and intestinal motility.
Manara L, Croci T, Landi M. Manara L, et al. Fundam Clin Pharmacol. 1995;9(4):332-42. doi: 10.1111/j.1472-8206.1995.tb00507.x. Fundam Clin Pharmacol. 1995. PMID: 8566932 Review.
Early substantial evidence of the low susceptibility to beta-adrenoceptor antagonists of non alpha-adrenergic responses reducing gut motility and tone was reluctantly accepted as indicating a third beta-receptor subtype different from the beta 1 and beta …
Early substantial evidence of the low susceptibility to beta-adrenoceptor antagonists of non alpha-adrenergic responses reducing gut …
Beta 3-adrenoceptors in the cardiovascular system.
Gauthier C, Sèze-Goismier C, Rozec B. Gauthier C, et al. Clin Hemorheol Microcirc. 2007;37(1-2):193-204. Clin Hemorheol Microcirc. 2007. PMID: 17641409 Review.
During the last decade, the characterization of a new beta-adrenoceptor subtype, beta(3), in addition to beta(1) and beta(2)-adrenoceptor in the cardiovascular system has changed the view of the roles of the sympathetic system. ...In vessels, all be …
During the last decade, the characterization of a new beta-adrenoceptor subtype, beta(3), in addition to beta(1) and …
New promising beta-lactamase inhibitors for clinical use.
Olsen I. Olsen I. Eur J Clin Microbiol Infect Dis. 2015 Jul;34(7):1303-8. doi: 10.1007/s10096-015-2375-0. Epub 2015 Apr 12. Eur J Clin Microbiol Infect Dis. 2015. PMID: 25864193 Review.
Clavulanate, sulbactam, and tazobactam have been used extensively for the last 30 years, together with beta-lactam antibiotics, to inhibit the effect of beta-lactamases. Although they have been useful as beta-lactamase inhibitors in many cases, their effectiv …
Clavulanate, sulbactam, and tazobactam have been used extensively for the last 30 years, together with beta-lactam antibiotics, to in …
Structure of coiled beta-beta-hairpins and beta-beta-corners.
Efimov AV. Efimov AV. FEBS Lett. 1991 Jun 24;284(2):288-92. doi: 10.1016/0014-5793(91)80706-9. FEBS Lett. 1991. PMID: 2060653 Free article. Review.
Two types of super-secondary structure, coiled beta-beta-hairpins and beta-beta-corners, are considered in this paper. A beta-beta-corner can be represented as a long beta-beta-hairpin folded orthogonally on itself so that t …
Two types of super-secondary structure, coiled beta-beta-hairpins and beta-beta-corners, are considered in this …
[beta-arrestin2 recruitment by beta-adrenergic receptor agonists and antagonists].
Wang YR, Cheng DQ, Ma L, Liu X. Wang YR, et al. Sheng Li Xue Bao. 2022 Dec 25;74(6):993-1004. Sheng Li Xue Bao. 2022. PMID: 36594387 Free article. Chinese.
Nonetheless, it remains unclear whether these commonly used beta-AR drugs can activate downstream beta- arrestin-biased signaling pathways. The objective of this study was to investigate beta-arrestin2 recruitment effects of beta-AR agonists and antago …
Nonetheless, it remains unclear whether these commonly used beta-AR drugs can activate downstream beta- arrestin-biased signal …
Beta-adrenoceptor regulation in the human heart: can it be monitored in circulating lymphocytes?
Brodde OE, Michel MC, Gordon EP, Sandoval A, Gilbert EM, Bristow MR. Brodde OE, et al. Eur Heart J. 1989 Jun;10 Suppl B:2-10. doi: 10.1093/eurheartj/10.suppl_b.2. Eur Heart J. 1989. PMID: 2553408 Review.
Furthermore, beta-adrenoceptor agonists and antagonists regulate lymphocyte beta 2- and cardiac beta 1- and beta 2-adrenoceptors in a subtype-selective fashion: while non-selective agonists (independent of exogenously applied or endogenously elevated) …
Furthermore, beta-adrenoceptor agonists and antagonists regulate lymphocyte beta 2- and cardiac beta 1- and beta …
1,427,054 results
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