Simvastatin inhibits CD44 fragmentation in chondrocytes.
Terabe K, Takahashi N, Takemoto T, Knudson W, Ishiguro N, Kojima T.
Terabe K, et al.
Arch Biochem Biophys. 2016 Aug 15;604:1-10. doi: 10.1016/j.abb.2016.05.019. Epub 2016 May 28.
Arch Biochem Biophys. 2016.
PMID: 27242325
Free article.
Three model systems of chondrocytes were examined including human HCS-2/8 chondrosarcoma cells, human osteoarthritic chondrocytes and normal bovine articular chondrocytes. Treatment with IL-1beta + Oncostatin M resulted in a substantial increase in CD44 fragmentation in ea …
Three model systems of chondrocytes were examined including human HCS-2/8 chondrosarcoma cells, human osteoarthritic chondrocytes and normal …