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Year Number of Results
1964 3
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1966 3
1967 1
1968 1
1970 3
1971 2
1973 10
1974 24
1975 562
1976 586
1977 506
1978 615
1979 661
1980 864
1981 1192
1982 1446
1983 1888
1984 2109
1985 2164
1986 2492
1987 2757
1988 3143
1989 3824
1990 4437
1991 5464
1992 7113
1993 7929
1994 9089
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1996 11162
1997 12412
1998 13732
1999 15070
2000 16476
2001 18174
2002 19769
2003 22730
2004 25741
2005 28408
2006 28881
2007 32535
2008 37438
2009 40343
2010 44389
2011 49206
2012 53937
2013 59519
2014 62898
2015 63893
2016 39123
2017 27207
2018 45451
2019 48903
2020 53494
2021 57127
2022 54819
2023 45873
2024 25098
2025 5254
2026 2

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1,006,724 results

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Page 1
Exploring the potential of structure-based deep learning approaches for T cell receptor design.
Ribeiro-Filho HV, Jara GE, Guerra JVS, Cheung M, Felbinger NR, Pereira JGC, Pierce BG, Lopes-de-Oliveira PS. Ribeiro-Filho HV, et al. PLoS Comput Biol. 2024 Sep 30;20(9):e1012489. doi: 10.1371/journal.pcbi.1012489. eCollection 2024 Sep. PLoS Comput Biol. 2024. PMID: 39348412 Free PMC article.
A relevant application is the design of T cell receptors (TCRs). Given the crucial role of T cells in mediating immune responses, redirecting these cells to tumor or infected target cells through the engineering of TCRs has shown promising results in treating …
A relevant application is the design of T cell receptors (TCRs). Given the crucial role of T cells in mediating immune …
Designing for Care.
Frigo G, Milchram C, Hillerbrand R. Frigo G, et al. Sci Eng Ethics. 2023 Apr 25;29(3):16. doi: 10.1007/s11948-023-00434-4. Sci Eng Ethics. 2023. PMID: 37097387 Free PMC article.
This article introduces Designing for Care (D4C), a distinctive approach to project management and technological design informed by Care Ethics. ...Although there may be several actors and stakeholders involved in project management and technological design, …
This article introduces Designing for Care (D4C), a distinctive approach to project management and technological design inform …
Against 'instantaneous' expertise.
Mebius A. Mebius A. Philos Ethics Humanit Med. 2022 Sep 21;17(1):11. doi: 10.1186/s13010-022-00123-3. Philos Ethics Humanit Med. 2022. PMID: 36127693 Free PMC article.
RESULTS: I propose that justification in many prominent accounts is based on the designer's professional experience and on expert testimony. I argue, however, that professional designers are not in a position to justify a new biotechnology or medical device i …
RESULTS: I propose that justification in many prominent accounts is based on the designer's professional experience and on exp …
Design rules of synthetic non-coding RNAs in bacteria.
Lee YJ, Moon TS. Lee YJ, et al. Methods. 2018 Jul 1;143:58-69. doi: 10.1016/j.ymeth.2018.01.001. Epub 2018 Jan 5. Methods. 2018. PMID: 29309838 Review.
The discovery of non-coding RNAs and their importance in cellular processing have rapidly attracted researchers' attention towards designing functional non-coding RNA molecules. These synthetic non-coding RNAs have simple design principles governed by Watson-Crick b …
The discovery of non-coding RNAs and their importance in cellular processing have rapidly attracted researchers' attention towards design …
Automatic Optimization of Wayfinding Design.
Huang H, Lin NC, Barrett L, Springer D, Wang HC, Pomplun M, Yu LF. Huang H, et al. IEEE Trans Vis Comput Graph. 2018 Sep;24(9):2516-2530. doi: 10.1109/TVCG.2017.2761820. Epub 2017 Oct 10. IEEE Trans Vis Comput Graph. 2018. PMID: 29028200
approach for automatically generating a wayfinding design for a given layout. The designer simply has to specify some navigation scenarios; our approach will automatically generate an optimized wayfinding design with signs properly placed considering human ag …
approach for automatically generating a wayfinding design for a given layout. The designer simply has to specify some navigati …
Rapid design of inclusive wireless technologies: A participatory workshop process.
Jones B, Gupta N, Persaud E, Phillips C. Jones B, et al. Assist Technol. 2022 Nov 2;34(6):661-667. doi: 10.1080/10400435.2021.1956642. Epub 2021 Nov 23. Assist Technol. 2022. PMID: 34814805
Yet, there is still opportunity to ensure upcoming designers of wireless technologies consider how their design helps or hinders their product's potential users. ...Workshop attendees rapidly worked through an inclusive design process identifying and defining …
Yet, there is still opportunity to ensure upcoming designers of wireless technologies consider how their design helps or hinde …
Synthetic biology principles for the design of protein with novel structures and functions.
Zhou W, Šmidlehner T, Jerala R. Zhou W, et al. FEBS Lett. 2020 Jul;594(14):2199-2212. doi: 10.1002/1873-3468.13796. Epub 2020 May 9. FEBS Lett. 2020. PMID: 32324903 Free article. Review.
Designed proteins exhibit several interesting features such as extreme stability, designability of 3D topologies and folding pathways. ...Recently, the design is expanding towards the introduction of new functions into designed proteins, and we may soo …
Designed proteins exhibit several interesting features such as extreme stability, designability of 3D topologies and folding p …
De Novo-Designed beta-Sheet Heme Proteins.
D'Souza A, Bhattacharjya S. D'Souza A, et al. Biochemistry. 2021 Feb 16;60(6):431-439. doi: 10.1021/acs.biochem.0c00662. Epub 2021 Feb 3. Biochemistry. 2021. PMID: 33533248 Review.
Initially, we designed a beta-hairpin peptide that self-assembles to bind heme and performs peroxidase activity in membrane. ...Collectively, these studies highlight the substantial progress made toward the design of functional beta-sheets....
Initially, we designed a beta-hairpin peptide that self-assembles to bind heme and performs peroxidase activity in membrane. ...Colle …
Communicating health information with visual displays.
Woloshin S, Yang Y, Fischhoff B. Woloshin S, et al. Nat Med. 2023 May;29(5):1085-1091. doi: 10.1038/s41591-023-02328-1. Epub 2023 May 8. Nat Med. 2023. PMID: 37156935 Review.
Poorly designed visual displays, however, can confuse and alienate recipients, undermining health messages. ...We also show simple, practical ways to evaluate a design's success and guide improvements. The proposed framework is grounded in research on health …
Poorly designed visual displays, however, can confuse and alienate recipients, undermining health messages. ...We also show simple, p …
Designing synthetic biology.
Agapakis CM. Agapakis CM. ACS Synth Biol. 2014 Mar 21;3(3):121-8. doi: 10.1021/sb4001068. Epub 2013 Nov 12. ACS Synth Biol. 2014. PMID: 24156739 Review.
The promise of these potential applications as well as the emphasis on design has prompted critical reflection on synthetic biology from design theorists and practicing designers from many fields, who can bring valuable perspectives to the discipline. ...Crit …
The promise of these potential applications as well as the emphasis on design has prompted critical reflection on synthetic biology f …
1,006,724 results
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