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34,079 results

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Page 1
Fanzor is a eukaryotic programmable RNA-guided endonuclease.
Saito M, Xu P, Faure G, Maguire S, Kannan S, Altae-Tran H, Vo S, Desimone A, Macrae RK, Zhang F. Saito M, et al. Nature. 2023 Aug;620(7974):660-668. doi: 10.1038/s41586-023-06356-2. Epub 2023 Jun 28. Nature. 2023. PMID: 37380027 Free PMC article.
RNA-guided systems, which use complementarity between a guide RNA and target nucleic acid sequences for recognition of genetic elements, have a central role in biological processes in both prokaryotes and eukaryotes. ...Cas effectors such as Cas9 and Cas12 perform …
RNA-guided systems, which use complementarity between a guide RNA and target nucleic acid sequences for recognition of genetic …
Biomaterials for Periodontal Regeneration.
Deng Y, Liang Y, Liu X. Deng Y, et al. Dent Clin North Am. 2022 Oct;66(4):659-672. doi: 10.1016/j.cden.2022.05.011. Epub 2022 Sep 11. Dent Clin North Am. 2022. PMID: 36216452 Free PMC article. Review.
This article summarizes recent progress in periodontal tissue regeneration from a biomaterial perspective. First, various guide tissue regeneration/guide bone regeneration membranes and grafting biomaterials for periodontal tissue regeneration are overviewed. ...
This article summarizes recent progress in periodontal tissue regeneration from a biomaterial perspective. First, various guide tissu …
Structural basis for pegRNA-guided reverse transcription by a prime editor.
Shuto Y, Nakagawa R, Zhu S, Hoki M, Omura SN, Hirano H, Itoh Y, Zhang F, Nureki O. Shuto Y, et al. Nature. 2024 Jul;631(8019):224-231. doi: 10.1038/s41586-024-07497-8. Epub 2024 May 29. Nature. 2024. PMID: 38811740 Free PMC article.
The prime editor system composed of Streptococcus pyogenes Cas9 nickase (nSpCas9) and engineered Moloney murine leukaemia virus reverse transcriptase (M-MLV RT) collaborates with a prime editing guide RNA (pegRNA) to facilitate a wide variety of precise genome edits …
The prime editor system composed of Streptococcus pyogenes Cas9 nickase (nSpCas9) and engineered Moloney murine leukaemia virus reverse tran …
Enhancement of Rebaudioside M Production by Structure-Guided Engineering of Glycosyltransferase UGT76G1.
Guo B, Deng Z, Meng F, Wang Q, Zhang Y, Yuan Z, Rao Y. Guo B, et al. J Agric Food Chem. 2022 Apr 27;70(16):5088-5094. doi: 10.1021/acs.jafc.2c01209. Epub 2022 Apr 13. J Agric Food Chem. 2022. PMID: 35417157
Owing to zero-calorie and advanced organoleptic properties similar to sucrose, the plant-derived rebaudioside M (Reb M) has been considered as a next generation sweetener. However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity …
Owing to zero-calorie and advanced organoleptic properties similar to sucrose, the plant-derived rebaudioside M (Reb M) has be …
Laser-guided lightning.
Houard A, Walch P, Produit T, Moreno V, Mahieu B, Sunjerga A, Herkommer C, Mostajabi A, Andral U, André YB, Lozano M, Bizet L, Schroeder MC, Schimmel G, Moret M, Stanley M, Rison WA, Maurice O, Esmiller B, Michel K, Haas W, Metzger T, Rubinstein M, Rachidi F, Cooray V, Mysyrowicz A, Kasparian J, Wolf JP. Houard A, et al. Nat Photonics. 2023;17(3):231-235. doi: 10.1038/s41566-022-01139-z. Epub 2023 Jan 16. Nat Photonics. 2023. PMID: 36909208 Free PMC article.
An experimental campaign was conducted on the Santis mountain in north-eastern Switzerland during the summer of 2021 with a high-repetition-rate terawatt laser. The guiding of an upward negative lightning leader over a distance of 50 m was recorded by two separate h …
An experimental campaign was conducted on the Santis mountain in north-eastern Switzerland during the summer of 2021 with a high-repetition- …
Implantoprosthetic Rehabilitation by Computer-guided Implant Surgery (M-Guide): Case report.
Bjelica R, Viskić J, Batinjan G, Filipović Zore I. Bjelica R, et al. Acta Stomatol Croat. 2022 Mar;56(1):89-94. doi: 10.15644/asc56/1/10. Acta Stomatol Croat. 2022. PMID: 35382487 Free PMC article.
Considering the fact of having a narrow area available for implantation, a computer-guided implant therapy using the M-Guide system was selected. The treatment plan was a prosthetic restoration involving the placement of two implants in areas 15 and 24 and th …
Considering the fact of having a narrow area available for implantation, a computer-guided implant therapy using the M-Guid …
Effect of Natriuretic Peptide-Guided Therapy on Hospitalization or Cardiovascular Mortality in High-Risk Patients With Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial.
Felker GM, Anstrom KJ, Adams KF, Ezekowitz JA, Fiuzat M, Houston-Miller N, Januzzi JL Jr, Mark DB, Piña IL, Passmore G, Whellan DJ, Yang H, Cooper LS, Leifer ES, Desvigne-Nickens P, O'Connor CM. Felker GM, et al. JAMA. 2017 Aug 22;318(8):713-720. doi: 10.1001/jama.2017.10565. JAMA. 2017. PMID: 28829876 Free PMC article. Clinical Trial.
DESIGN, SETTINGS, AND PARTICIPANTS: The Guiding Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure (GUIDE-IT) study was a randomized multicenter clinical trial conducted between January 16, 2013, and September 20, 2016, at 45 clinical site …
DESIGN, SETTINGS, AND PARTICIPANTS: The Guiding Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure (GUI …
The miniature CRISPR-Cas12m effector binds DNA to block transcription.
Wu WY, Mohanraju P, Liao C, Adiego-Pérez B, Creutzburg SCA, Makarova KS, Keessen K, Lindeboom TA, Khan TS, Prinsen S, Joosten R, Yan WX, Migur A, Laffeber C, Scott DA, Lebbink JHG, Koonin EV, Beisel CL, van der Oost J. Wu WY, et al. Mol Cell. 2022 Dec 1;82(23):4487-4502.e7. doi: 10.1016/j.molcel.2022.11.003. Epub 2022 Nov 24. Mol Cell. 2022. PMID: 36427491 Free article.
Cas nucleases generally use CRISPR-derived RNA guides to specifically bind and cleave DNA or RNA targets. Here, we describe the experimental characterization of a bacterial CRISPR effector protein Cas12m representing subtype V-M. Despite being less than half the siz …
Cas nucleases generally use CRISPR-derived RNA guides to specifically bind and cleave DNA or RNA targets. Here, we describe the exper …
Procalcitonin-Guided Antibiotic Therapy.
John M. Eisenberg Center for Clinical Decisions and Communications Science. John M. Eisenberg Center for Clinical Decisions and Communications Science. 2012 Oct 5. In: Comparative Effectiveness Review Summary Guides for Clinicians [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2007–. 2012 Oct 5. In: Comparative Effectiveness Review Summary Guides for Clinicians [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2007–. PMID: 23193609 Free Books & Documents. Review.
MRI-guided endovascular intervention: current methods and future potential.
Kilbride BF, Narsinh KH, Jordan CD, Mueller K, Moore T, Martin AJ, Wilson MW, Hetts SW. Kilbride BF, et al. Expert Rev Med Devices. 2022 Oct;19(10):763-778. doi: 10.1080/17434440.2022.2141110. Expert Rev Med Devices. 2022. PMID: 36373162 Free PMC article. Review.
AREAS COVERED: In this review, the benefits and limitations of MRI-guided endovascular interventions are addressed, systems and devices for guiding such interventions are summarized, and clinical applications are discussed. ...Translational research and further prec …
AREAS COVERED: In this review, the benefits and limitations of MRI-guided endovascular interventions are addressed, systems and devic …
34,079 results
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