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1928 1
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1950 1069
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1952 1368
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1955 1982
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1974 13450
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1976 12402
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1987 18409
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2009 45724
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2012 54234
2013 55978
2014 56705
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1,750,321 results

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Page 1
Polymer-Lipid Hybrid Materials.
Go YK, Leal C. Go YK, et al. Chem Rev. 2021 Nov 24;121(22):13996-14030. doi: 10.1021/acs.chemrev.1c00755. Epub 2021 Nov 9. Chem Rev. 2021. PMID: 34752064 Free PMC article. Review.
Synthetic block copolymers capture many of lipid's structural and functional properties. Lipids are typically biocompatible and high molecular weight polymers are mechanically robust and chemically versatile. The development of new materials for applications …
Synthetic block copolymers capture many of lipid's structural and functional properties. Lipids are typically biocompat …
LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury.
Nakamura S, Shigeyama S, Minami S, Shima T, Akayama S, Matsuda T, Esposito A, Napolitano G, Kuma A, Namba-Hamano T, Nakamura J, Yamamoto K, Sasai M, Tokumura A, Miyamoto M, Oe Y, Fujita T, Terawaki S, Takahashi A, Hamasaki M, Yamamoto M, Okada Y, Komatsu M, Nagai T, Takabatake Y, Xu H, Isaka Y, Ballabio A, Yoshimori T. Nakamura S, et al. Nat Cell Biol. 2020 Oct;22(10):1252-1263. doi: 10.1038/s41556-020-00583-9. Epub 2020 Sep 28. Nat Cell Biol. 2020. PMID: 32989250
Here we show that transcription factor EB (TFEB)-a master transcriptional regulator of lysosomal biogenesis and autophagy-is activated during the lysosomal damage response, and its activation is dependent on the function of the ATG conjugation system, which mediates LC3 lipida
Here we show that transcription factor EB (TFEB)-a master transcriptional regulator of lysosomal biogenesis and autophagy-is activated durin …
Protein lipidation in health and disease: molecular basis, physiological function and pathological implication.
Yuan Y, Li P, Li J, Zhao Q, Chang Y, He X. Yuan Y, et al. Signal Transduct Target Ther. 2024 Mar 15;9(1):60. doi: 10.1038/s41392-024-01759-7. Signal Transduct Target Ther. 2024. PMID: 38485938 Free PMC article. Review.
Decades of dedicated research have driven the development of a wide range of drugs targeting protein lipidation, and several agents have been developed and tested in preclinical and clinical studies, some of which, such as asciminib and lonafarnib are FDA-approved for ther …
Decades of dedicated research have driven the development of a wide range of drugs targeting protein lipidation, and several agents h …
Cellular lipidomics.
van Meer G. van Meer G. EMBO J. 2005 Sep 21;24(18):3159-65. doi: 10.1038/sj.emboj.7600798. Epub 2005 Sep 1. EMBO J. 2005. PMID: 16138081 Free PMC article. Review.
To incorporate function, cellular lipidomics must not only determine which lipids are present but also the concentration of each lipid at each specific intracellular location in time and the lipid's interaction partners. Moreover, cellular lipidomics m …
To incorporate function, cellular lipidomics must not only determine which lipids are present but also the concentration of each l
[LIPIDS AND CANCER].
SCHMIDT F. SCHMIDT F. Krebsarzt. 1964;19:251-64. Krebsarzt. 1964. PMID: 14251508 Review. German. No abstract available.
From the banal to the bizarre: unravelling immune recognition and response to microbial lipids.
Burchill L, Williams SJ. Burchill L, et al. Chem Commun (Camb). 2022 Jan 20;58(7):925-940. doi: 10.1039/d1cc06003a. Chem Commun (Camb). 2022. PMID: 34989357 Review.
Microbes produce a rich array of lipidic species that through their location in the cell wall and ability to mingle with host lipids represent a privileged class of immune-active molecules. Lipid-sensing immunity recognizes microbial lipids from pathog …
Microbes produce a rich array of lipidic species that through their location in the cell wall and ability to mingle with host lipi
Peptide Lipidation - A Synthetic Strategy to Afford Peptide Based Therapeutics.
Kowalczyk R, Harris PWR, Williams GM, Yang SH, Brimble MA. Kowalczyk R, et al. Adv Exp Med Biol. 2017;1030:185-227. doi: 10.1007/978-3-319-66095-0_9. Adv Exp Med Biol. 2017. PMID: 29081055 Free PMC article. Review.
Peptide and protein aberrant lipidation patterns are often involved in many diseases including cancer and neurological disorders. ...Self-adjuvanting peptide-based vaccines commonly utilise the powerful TLR2 agonist Pam(n)Cys lipid to stimulate adjuvant activity. Th …
Peptide and protein aberrant lipidation patterns are often involved in many diseases including cancer and neurological disorders. ... …
A review of lipidation in the development of advanced protein and peptide therapeutics.
Menacho-Melgar R, Decker JS, Hennigan JN, Lynch MD. Menacho-Melgar R, et al. J Control Release. 2019 Feb 10;295:1-12. doi: 10.1016/j.jconrel.2018.12.032. Epub 2018 Dec 21. J Control Release. 2019. PMID: 30579981 Free PMC article. Review.
Despite its great potential, lipidation remains an underutilized strategy in the clinical translation of lead biologics. We review how lipidation can overcome common challenges in biologics development as well as highlight gaps in our understanding of the effect of …
Despite its great potential, lipidation remains an underutilized strategy in the clinical translation of lead biologics. We review ho …
ApoE Lipidation as a Therapeutic Target in Alzheimer's Disease.
Lanfranco MF, Ng CA, Rebeck GW. Lanfranco MF, et al. Int J Mol Sci. 2020 Sep 1;21(17):6336. doi: 10.3390/ijms21176336. Int J Mol Sci. 2020. PMID: 32882843 Free PMC article. Review.
Here we highlight the importance of lipidated apoE as well as the APOE-lipidation targeted therapeutic approaches that have the potential to correct or prevent neurodegeneration. ...Overall, there is great potential to improve the lipidated state of apoE with …
Here we highlight the importance of lipidated apoE as well as the APOE-lipidation targeted therapeutic approaches that have th …
Nuclear lipids in chromatin regulation: Biological roles, experimental approaches and existing challenges.
Sayed A, Eswara K, Teles K, Boudellioua A, Fischle W. Sayed A, et al. Biol Cell. 2025 Jan;117(1):e2400103. doi: 10.1111/boc.202400103. Epub 2024 Dec 8. Biol Cell. 2025. PMID: 39648467 Free PMC article. Review.
Recent studies suggest that nuclear lipids play a role in chromatin regulation and epigenetics. Here, we discuss various experimental methods in lipid-chromatin research, including biophysical, structural, and cell biology approaches, pointing out their strengths an …
Recent studies suggest that nuclear lipids play a role in chromatin regulation and epigenetics. Here, we discuss various experimental …
1,750,321 results
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