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Page 1
Oxysterols direct immune cell migration via EBI2.
Hannedouche S, Zhang J, Yi T, Shen W, Nguyen D, Pereira JP, Guerini D, Baumgarten BU, Roggo S, Wen B, Knochenmuss R, Noël S, Gessier F, Kelly LM, Vanek M, Laurent S, Preuss I, Miault C, Christen I, Karuna R, Li W, Koo DI, Suply T, Schmedt C, Peters EC, Falchetto R, Katopodis A, Spanka C, Roy MO, Detheux M, Chen YA, Schultz PG, Cho CY, Seuwen K, Cyster JG, Sailer AW. Hannedouche S, et al. Nature. 2011 Jul 27;475(7357):524-7. doi: 10.1038/nature10280. Nature. 2011. PMID: 21796212 Free PMC article.
Here we describe the identification of 7alpha,25-dihydroxycholesterol (also called 7alpha,25-OHC or 5-cholesten-3beta,7alpha,25-triol) as a potent and selective agonist of EBI2. Functional activation of human EBI2 by 7alpha,25-OHC and closely related oxysterols was …
Here we describe the identification of 7alpha,25-dihydroxycholesterol (also called 7alpha,25-OHC or 5-cholesten-3beta,7alpha,25-triol …
Prestin and electromotility may serve multiple roles in cochlear outer hair cells.
Zheng J, Takahashi S, Zhou Y, Cheatham MA. Zheng J, et al. Hear Res. 2022 Sep 15;423:108428. doi: 10.1016/j.heares.2021.108428. Epub 2021 Dec 26. Hear Res. 2022. PMID: 34987016 Review.
It has also been demonstrated that prestin provides the molecular basis for OHC somatic electromotility, amplifying movements within the organ of Corti. Although not anticipated, early-onset OHC loss was found in two prestin transgenic mouse models that either lack …
It has also been demonstrated that prestin provides the molecular basis for OHC somatic electromotility, amplifying movements within …
Fluorinated polyethyleneimine vectors with serum resistance and adjuvant effect to deliver LMP2 mRNA vaccine for nasopharyngeal carcinoma therapy.
Yang S, Chen R, Wu Y, Song X, Peng X, Chen M. Yang S, et al. Acta Biomater. 2025 Jan 15;192:340-352. doi: 10.1016/j.actbio.2024.12.022. Epub 2024 Dec 8. Acta Biomater. 2025. PMID: 39657865
Specifically, the proposed vaccine PEG[(TK)PF/mLMP2] was comprised of a (TK)PF/mLMP2 core formed by the cationic (TK)PF and LMP2 mRNA, together with a dialdehyde poly (ethyl glycol) (OHC-PEG-CHO) coating. PEG[(TK)PF/mLMP2] showed less protein absorption to enable serum res …
Specifically, the proposed vaccine PEG[(TK)PF/mLMP2] was comprised of a (TK)PF/mLMP2 core formed by the cationic (TK)PF and LMP2 mRNA, toget …
27-Hydroxycholesterol increases α-synuclein protein levels through proteasomal inhibition in human dopaminergic neurons.
Schommer J, Marwarha G, Schommer T, Flick T, Lund J, Ghribi O. Schommer J, et al. BMC Neurosci. 2018 Apr 3;19(1):17. doi: 10.1186/s12868-018-0420-5. BMC Neurosci. 2018. Retraction in: BMC Neurosci. 2024 Nov 7;25(1):70. doi: 10.1186/s12868-024-00910-y. PMID: 29614969 Free PMC article. Retracted.
Several studies suggest a link between synucleinopathies and the cholesterol metabolite 27-hydroxycholesterol (27-OHC). 27-OHC is the major cholesterol metabolite in the blood that crosses the blood brain barrier, and its levels can increase following hypercholester …
Several studies suggest a link between synucleinopathies and the cholesterol metabolite 27-hydroxycholesterol (27-OHC). 27-OHC …
Expression of anti and pro-inflammatory genes in human endothelial cells activated by 25-hydroxycholesterol: A comparison of rivaroxaban and dabigatran.
Gorzelak-Pabiś P, Pawlos A, Broncel M, Wojdan K, Woźniak E. Gorzelak-Pabiś P, et al. Clin Exp Pharmacol Physiol. 2022 Aug;49(8):805-812. doi: 10.1111/1440-1681.13668. Epub 2022 Jun 8. Clin Exp Pharmacol Physiol. 2022. PMID: 35577580
Chronic inflammation, vascular proliferation and the development of atherosclerosis is also influenced by 25-hydroxycholesterol (25-OHC). The aim of the study was to assess the effect of rivaroxaban and dabigatran on the messenger RNA (mRNA) expression of anti-infla …
Chronic inflammation, vascular proliferation and the development of atherosclerosis is also influenced by 25-hydroxycholesterol (25-OHC …
Expression pattern of mammalian cochlea outer hair cell (OHC) mRNA: screening of a rat OHC cDNA library.
Harter C, Ripoll C, Lenoir M, Hamel CP, Rebillard G. Harter C, et al. DNA Cell Biol. 1999 Jan;18(1):1-10. doi: 10.1089/104454999315574. DNA Cell Biol. 1999. PMID: 10025504
Another protein, the oncomodulin recently shown to be OHC specific, was also found, and its mRNA expression was confirmed by in situ hybridization. ...
Another protein, the oncomodulin recently shown to be OHC specific, was also found, and its mRNA expression was confirmed by in situ …
27-Hydroxycholesterol regulates cholesterol synthesis and transport in C6 glioma cells.
An Y, Zhang DD, Yu HL, Ma WW, Lu YH, Liu QR, Xiao R. An Y, et al. Neurotoxicology. 2017 Mar;59:88-97. doi: 10.1016/j.neuro.2017.02.001. Epub 2017 Feb 3. Neurotoxicology. 2017. PMID: 28167099
The oxysterol 27-Hydroxycholesterol (27-OHC) is a major cholesterol metabolite that can cross the blood brain barrier (BBB) from peripheral circulation to the brain. Currently, the role of 27-OHC on cholesterol homeostasis in astrocytes and the underlying mechanisms …
The oxysterol 27-Hydroxycholesterol (27-OHC) is a major cholesterol metabolite that can cross the blood brain barrier (BBB) from peri …
The effect of lipid-lowering therapies on the pro-inflammatory and anti-inflammatory properties of vascular endothelial cells.
Woźniak E, Broncel M, Niedzielski M, Woźniak A, Gorzelak-Pabiś P. Woźniak E, et al. PLoS One. 2023 Feb 8;18(2):e0280741. doi: 10.1371/journal.pone.0280741. eCollection 2023. PLoS One. 2023. PMID: 36753488 Free PMC article.
Chronic inflammation, vascular proliferation, and the development of atherosclerosis are also influenced by 25-hydroxycholesterol (25-OHC). The aim of the study was to compare the direct pleiotropic effects of two commonly-used statins (atorvastatin, rosuvastatin), ezetimi …
Chronic inflammation, vascular proliferation, and the development of atherosclerosis are also influenced by 25-hydroxycholesterol (25-OHC …
Dabigatran: its protective effect against endothelial cell damage by oxysterol.
Gorzelak-Pabiś P, Broncel M, Pawlos A, Wojdan K, Gajewski A, Chałubiński M, Woźniak E. Gorzelak-Pabiś P, et al. Biomed Pharmacother. 2022 Mar;147:112679. doi: 10.1016/j.biopha.2022.112679. Epub 2022 Feb 2. Biomed Pharmacother. 2022. PMID: 35121342 Free article.

VE-cadherin expression in endothelial cells was evaluated by confocal microscopy. Pre-stimulation of HUVECs with 25-OHC decreased endothelial cell integrity (p < 0.001) and increased the expression of IL-33, ICAM-1, MCP-1, VEGF, TNF-alpha mRNA (p < 0.01) compared to

…
VE-cadherin expression in endothelial cells was evaluated by confocal microscopy. Pre-stimulation of HUVECs with 25-OHC decreased end …
Associations between plasma 24(S)-hydroxycholesterol and neuropsychological profile in fragile X syndrome.
Laroui A, Rojas D, Bouhour S, Proteau-Lemieux M, Galarneau L, Benachenhou S, Abolghasemi A, Plantefeve R, Mallet PL, Corbin F, Lepage JF, Çaku A. Laroui A, et al. J Lipid Res. 2025 May;66(5):100787. doi: 10.1016/j.jlr.2025.100787. Epub 2025 Mar 27. J Lipid Res. 2025. PMID: 40157575 Free PMC article.
Plasma levels of 24(S)-OHC and 27-OHC were quantified in FXS and control individuals. The FXS group underwent transcranial magnetic stimulation to evaluate corticospinal excitability and inhibition. ...Larger studies are warranted to confirm the potential of 24(S)- …
Plasma levels of 24(S)-OHC and 27-OHC were quantified in FXS and control individuals. The FXS group underwent transcranial mag …
52 results