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Year Number of Results
2003 9
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7,524 results

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Page 1
Nanog, as a key cancer stem cell marker in tumor progression.
Vasefifar P, Motafakkerazad R, Maleki LA, Najafi S, Ghrobaninezhad F, Najafzadeh B, Alemohammad H, Amini M, Baghbanzadeh A, Baradaran B. Vasefifar P, et al. Gene. 2022 Jun 15;827:146448. doi: 10.1016/j.gene.2022.146448. Epub 2022 Mar 22. Gene. 2022. PMID: 35337852 Review.
Nanog through different signaling pathways, like JAK/STAT and Wnt/beta-catenin pathways, induces stemness, self-renewal, metastasis, invasiveness, and chemoresistance of cancer cells. ...Therefore, this review aimed to focus on the function of Nanog in multiple canc …
Nanog through different signaling pathways, like JAK/STAT and Wnt/beta-catenin pathways, induces stemness, self-renewal, metastasis, …
A NANOG-pERK reciprocal regulatory circuit regulates Nanog autoregulation and ERK signaling dynamics.
Kale HT, Rajpurohit RS, Jana D, Vishnu VV, Srivastava M, Mourya PR, Srinivas G, Shekar PC. Kale HT, et al. EMBO Rep. 2022 Nov 7;23(11):e54421. doi: 10.15252/embr.202154421. Epub 2022 Sep 6. EMBO Rep. 2022. PMID: 36066347 Free PMC article.
Here, we show that a dose-dependent induction of Fgfbp1 and Fgfr2 by NANOG activates autocrine-mediated ERK signaling in Nanog-high cells to trigger autorepression. pERK recruits NONO to the Nanog locus to repress transcription by preventing POL2 loading. Thi …
Here, we show that a dose-dependent induction of Fgfbp1 and Fgfr2 by NANOG activates autocrine-mediated ERK signaling in Nanog …
The multiple faces of NANOG in cancer: a therapeutic target to chemosensitize therapy-resistant cancers.
Fatma H, Siddique HR, Maurya SK. Fatma H, et al. Epigenomics. 2021 Dec;13(23):1885-1900. doi: 10.2217/epi-2021-0228. Epub 2021 Oct 25. Epigenomics. 2021. PMID: 34693722 Review.
The current review focuses on NANOG regulation in the various signaling networks leading to cancer progression and chemoresistance, and highlights the therapeutic aspect of targeting NANOG in various cancers. Lay abstract NANOG is a gene that is mainly expres …
The current review focuses on NANOG regulation in the various signaling networks leading to cancer progression and chemoresistance, a …
NANOG: a promising target for digestive malignant tumors.
Sun AX, Liu CJ, Sun ZQ, Wei Z. Sun AX, et al. World J Gastroenterol. 2014 Sep 28;20(36):13071-8. doi: 10.3748/wjg.v20.i36.13071. World J Gastroenterol. 2014. PMID: 25278701 Free PMC article. Review.
NANOG has been extensively researched since its discovery by Chambers et al. NANOG is a homeodomain transcription factor and an essential regulator of embryonic stem cell (ESC) self-renewal, which inhibits differentiation. ...NANOG cooperates with other regul …
NANOG has been extensively researched since its discovery by Chambers et al. NANOG is a homeodomain transcription factor and a …
Insights into the Nanog gene: A propeller for stemness in primitive stem cells.
Zhang W, Sui Y, Ni J, Yang T. Zhang W, et al. Int J Biol Sci. 2016 Oct 25;12(11):1372-1381. doi: 10.7150/ijbs.16349. eCollection 2016. Int J Biol Sci. 2016. PMID: 27877089 Free PMC article. Review.
In this review we summarized the recent understanding of the roles and mechanisms of Nanog in ESC regulation under physiological conditions. In addition, we describe the function of Nanog family proteins in different types of cancer, and the association of Nanog …
In this review we summarized the recent understanding of the roles and mechanisms of Nanog in ESC regulation under physiological cond …
The clinicopathological and prognostic value of Nanog in human gastrointestinal luminal cancer: A meta-analysis.
Liang C, Zhao T, Ge H, Xu Y, Ren S, Yue C, Li G, Wu J. Liang C, et al. Int J Surg. 2018 May;53:193-200. doi: 10.1016/j.ijsu.2018.03.050. Epub 2018 Mar 28. Int J Surg. 2018. PMID: 29602014 Free article. Review.
BACKGROUND: Recent studies have demonstrated that the over-expression of Nanog contributes to the progression of various malignant tumors. However, the clinicopathological and prognostic role of Nanog in gastrointestinal luminal cancer remains controversial. ...CONC …
BACKGROUND: Recent studies have demonstrated that the over-expression of Nanog contributes to the progression of various malignant tu …
Stem cell transcription factor NANOG in cancers--is eternal youth a curse?
Wong OG, Cheung AN. Wong OG, et al. Expert Opin Ther Targets. 2016;20(4):407-17. doi: 10.1517/14728222.2016.1112791. Epub 2015 Dec 4. Expert Opin Ther Targets. 2016. PMID: 26634876 Review.
Overexpression of NANOG has been observed in various human malignancies. Several reports have suggested that NANOG contributes to carcinogenesis by initiating and preserving cancer stem cells. ...Novel approaches need to be explored before the inhibition of NANOG …
Overexpression of NANOG has been observed in various human malignancies. Several reports have suggested that NANOG contributes …
Chicken NANOG self-associates via a novel folding-upon-binding mechanism.
Choi HJ, Kim I, Lee HJ, Park YH, Suh JY, Han JY. Choi HJ, et al. FASEB J. 2018 May;32(5):2563-2573. doi: 10.1096/fj.201700924RR. Epub 2018 Jan 2. FASEB J. 2018. PMID: 29295863
Mammalian NANOG self-associates via conserved tryptophan-repeat motifs in the C-terminal domain (CTD) to maintain pluripotency. ...J., Park, Y. H., Suh, J.-Y., Han, J. Y. Chicken NANOG self-associates via a novel folding-upon-binding mechanism....
Mammalian NANOG self-associates via conserved tryptophan-repeat motifs in the C-terminal domain (CTD) to maintain pluripotency. ...J. …
Micelle-like clusters in phase-separated Nanog condensates: A molecular simulation study.
Mizutani A, Tan C, Sugita Y, Takada S. Mizutani A, et al. PLoS Comput Biol. 2023 Jul 24;19(7):e1011321. doi: 10.1371/journal.pcbi.1011321. eCollection 2023 Jul. PLoS Comput Biol. 2023. PMID: 37486948 Free PMC article.
Mutation of tryptophan residues in the WR region which was implicated to be important for a Nanog function resulted in dissolution of the Nanog condensate. Finally, to examine the impact of Nanog cluster to DNA, we added DNA fragments to the Nanog cond …
Mutation of tryptophan residues in the WR region which was implicated to be important for a Nanog function resulted in dissolution of …
Elucidating the immunohistochemistry of Nanog: A transcription marker in the oral squamous cell carcinoma with emphasis on its origin as embryonic stem cell.
Afroze SN, Rao GV, Suri S. Afroze SN, et al. J Oral Maxillofac Pathol. 2022 Oct-Dec;26(4):476-482. doi: 10.4103/jomfp.jomfp_347_22. Epub 2022 Dec 22. J Oral Maxillofac Pathol. 2022. PMID: 37082043 Free PMC article.
BACKGROUND: Nanog is a key transcription factor regulating pluripotency in mammalian early embryos and pluripotent stem cells. Nanog plays a central role in pluripotency and forms autoregulatory loops to maintain ESC (embryonic stem cell) identity. ...
BACKGROUND: Nanog is a key transcription factor regulating pluripotency in mammalian early embryos and pluripotent stem cells. Nan …
7,524 results