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Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW. Huttlin EL, et al. Nature. 2017 May 25;545(7655):505-509. doi: 10.1038/nature22366. Epub 2017 May 17. Nature. 2017. PMID: 28514442 Free PMC article.
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Huttlin EL, Ting L, Bruckner RJ, Gebreab F, Gygi MP, Szpyt J, Tam S, Zarraga G, Colby G, Baltier K, Dong R, Guarani V, Vaites LP, Ordureau A, Rad R, Erickson BK, Wühr M, Chick J, Zhai B, Kolippakkam D, Mintseris J, Obar RA, Harris T, Artavanis-Tsakonas S, Sowa ME, De Camilli P, Paulo JA, Harper JW, Gygi SP. Huttlin EL, et al. Cell. 2015 Jul 16;162(2):425-440. doi: 10.1016/j.cell.2015.06.043. Cell. 2015. PMID: 26186194 Free PMC article.
APOE Christchurch-mimetic therapeutic antibody reduces APOE-mediated toxicity and tau phosphorylation.
Marino C, Perez-Corredor P, O'Hare M, Heuer A, Chmielewska N, Gordon H, Chandrahas AS, Gonzalez-Buendia L, Delgado-Tirado S, Doan TH, Vanderleest TE, Arevalo-Alquichire S, Obar RA, Ortiz-Cordero C, Villegas A, Sepulveda-Falla D, Kim LA, Lopera F, Mahley R, Huang Y, Quiroz YT, Arboleda-Velasquez JF. Marino C, et al. Alzheimers Dement. 2024 Feb;20(2):819-836. doi: 10.1002/alz.13436. Epub 2023 Oct 4. Alzheimers Dement. 2024. PMID: 37791598 Free PMC article.
ApoE3 Christchurch and tau interaction as a protective mechanism against Alzheimer's disease.
Perez-Corredor P, Arevalo-Alquichire S, Mazzarino RC, O'Hare M, Muriel-Torres AF, Vacano GN, Vanderleest TE, Miller WP, Pineda-Lopez L, Patel S, Obar RA, Polat N, Kim LA, Arboleda-Velasquez JF, Marino C. Perez-Corredor P, et al. Alzheimers Dement. 2025 Jul;21(7):e70396. doi: 10.1002/alz.70396. Alzheimers Dement. 2025. PMID: 40637118 Free PMC article.
Transcription factor networks in Drosophila melanogaster.
Rhee DY, Cho DY, Zhai B, Slattery M, Ma L, Mintseris J, Wong CY, White KP, Celniker SE, Przytycka TM, Gygi SP, Obar RA, Artavanis-Tsakonas S. Rhee DY, et al. Cell Rep. 2014 Sep 25;8(6):2031-2043. doi: 10.1016/j.celrep.2014.08.038. Epub 2014 Sep 18. Cell Rep. 2014. PMID: 25242320 Free PMC article.
Proteomic analysis of the Notch interactome.
Guruharsha KG, Hori K, Obar RA, Artavanis-Tsakonas S. Guruharsha KG, et al. Methods Mol Biol. 2014;1187:181-92. doi: 10.1007/978-1-4939-1139-4_14. Methods Mol Biol. 2014. PMID: 25053490
Next-generation Drosophila protein interactome map and its functional implications.
Bhat G, Li K, Locke G, Theodorou M, Kilambi K, Hori K, Ho D, Obar R, Williams L, Parzen H, Dephoure N, Braun C, Muskavitch M, Celniker SE, Gygi S, Artavanis-Tsakonas S. Bhat G, et al. Dev Cell. 2024 Sep 23;59(18):2506-2517.e6. doi: 10.1016/j.devcel.2024.06.002. Epub 2024 Jun 28. Dev Cell. 2024. PMID: 38944040 Free article.
A protein complex network of Drosophila melanogaster.
Guruharsha KG, Rual JF, Zhai B, Mintseris J, Vaidya P, Vaidya N, Beekman C, Wong C, Rhee DY, Cenaj O, McKillip E, Shah S, Stapleton M, Wan KH, Yu C, Parsa B, Carlson JW, Chen X, Kapadia B, VijayRaghavan K, Gygi SP, Celniker SE, Obar RA, Artavanis-Tsakonas S. Guruharsha KG, et al. Cell. 2011 Oct 28;147(3):690-703. doi: 10.1016/j.cell.2011.08.047. Cell. 2011. PMID: 22036573 Free PMC article.
33 results