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75 results

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Page 1
Exploring Origin-Dependent Susceptibility of Smooth Muscle Cells to Aortic Diseases Through Intersectional Genetics.
Han X, Li Y, Wang E, Zhu H, Huang X, Pu W, Zhang M, Liu K, Zhao H, Liu Z, Zhao Y, Shen L, Li Y, Yang X, Wang QD, Ma X, Shen R, O Lui K, Wang L, He B, Zhou B. Han X, et al. Circulation. 2025 Apr 29;151(17):1248-1267. doi: 10.1161/CIRCULATIONAHA.124.070782. Epub 2025 Feb 10. Circulation. 2025. PMID: 39925267
BACKGROUND: The developmental diversity among smooth muscle cells (SMCs) plays a crucial role in segment-specific aortic diseases. However, traditional genetic approaches are inadequate for enabling in vivo analysis of disease susceptibility associated with cellular origin …
BACKGROUND: The developmental diversity among smooth muscle cells (SMCs) plays a crucial role in segment-specific aortic diseases. Ho …
Smooth Muscle Mineralocorticoid Receptor Promotes Hypertension After Preeclampsia.
Biwer LA, Lu Q, Ibarrola J, Stepanian A, Man JJ, Carvajal BV, Camarda ND, Zsengeller Z, Skurnik G, Seely EW, Karumanchi SA, Jaffe IZ. Biwer LA, et al. Circ Res. 2023 Mar 17;132(6):674-689. doi: 10.1161/CIRCRESAHA.122.321228. Epub 2023 Feb 23. Circ Res. 2023. PMID: 36815487 Free PMC article.
After preeclampsia, women have enhanced sensitivity to hypertensive stress. Since smooth muscle cell mineralocorticoid receptors (SMC-MR) are activated by hypertensive stimuli, we hypothesized that high sFlt1 exposure in pregnancy induces a postpartum state of enhanced SMC …
After preeclampsia, women have enhanced sensitivity to hypertensive stress. Since smooth muscle cell mineralocorticoid receptors (SMC …
Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension.
Masson B, Le Ribeuz H, Sabourin J, Laubry L, Woodhouse E, Foster R, Ruchon Y, Dutheil M, Boët A, Ghigna MR, De Montpreville VT, Mercier O, Beech DJ, Benitah JP, Bailey MA, Humbert M, Montani D, Capuano V, Antigny F. Masson B, et al. Circ Res. 2022 Oct 14;131(9):e102-e119. doi: 10.1161/CIRCRESAHA.122.321041. Epub 2022 Sep 27. Circ Res. 2022. PMID: 36164973 Free article.
Exacerbated intracellular calcium (Ca(2+)) signaling contributes to abnormalities in PA smooth muscle cells (PASMCs), including aberrant proliferation, apoptosis resistance, exacerbated migration, and arterial contractility. ...
Exacerbated intracellular calcium (Ca(2+)) signaling contributes to abnormalities in PA smooth muscle cells (PASMCs), including aberr …
Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy.
Hartman JJ, Hwee DT, Robert-Paganin J, Chuang C, Chin ER, Edell S, Lee KH, Madhvani R, Paliwal P, Pernier J, Sarkar SS, Schaletzky J, Schauer K, Taheri KD, Wang J, Wehri E, Wu Y, Houdusse A, Morgan BP, Malik FI. Hartman JJ, et al. Nat Cardiovasc Res. 2024 Aug;3(8):1003-1016. doi: 10.1038/s44161-024-00505-0. Epub 2024 Jul 23. Nat Cardiovasc Res. 2024. PMID: 39196032 Free PMC article.
The crystal structure of aficamten bound to cardiac myosin in the pre-powerstroke state provides a basis for understanding its selectivity over smooth and fast skeletal muscle. Furthermore, in cardiac myocytes and in mice bearing the hypertrophic R403Q cardiac myosin mutat …
The crystal structure of aficamten bound to cardiac myosin in the pre-powerstroke state provides a basis for understanding its selectivity o …
The Diabetes Technology Society Error Grid and Trend Accuracy Matrix for Glucose Monitors.
Klonoff DC, Freckmann G, Pleus S, Kovatchev BP, Kerr D, Tse CC, Li C, Agus MSD, Dungan K, Voglová Hagerf B, Krouwer JS, Lee WA, Misra S, Rhee SY, Sabharwal A, Seley JJ, Shah VN, Tran NK, Waki K, Worth C, Tian T, Aaron RE, Rutledge K, Ho CN, Ayers AT, Adler A, Ahn DT, Aktürk HK, Al-Sofiani ME, Bailey TS, Baker M, Bally L, Bannuru RR, Bauer EM, Bee YM, Blanchette JE, Cengiz E, Chase JG, Y Chen K, Cherñavvsky D, Clements M, Cote GL, Dhatariya KK, Drincic A, Ejskjaer N, Espinoza J, Fabris C, Fleming GA, Gabbay MAL, Galindo RJ, Gómez-Medina AM, Heinemann L, Hermanns N, Hoang T, Hussain S, Jacobs PG, Jendle J, Joshi SR, Koliwad SK, Lal RA, Leiter LA, Lind M, Mader JK, Maran A, Masharani U, Mathioudakis N, McShane M, Mehta C, Moon SJ, Nichols JH, O'Neal DN, Pasquel FJ, Peters AL, Pfützner A, Pop-Busui R, Ranjitkar P, Rhee CM, Sacks DB, Schmidt S, Schwaighofer SM, Sheng B, Simonson GD, Sode K, Spanakis EK, Spartano NL, Umpierrez GE, Vareth M, Vesper HW, Wang J, Wright E, Wu AHB, Yeshiwas S, Zilbermint M, Kohn MA. Klonoff DC, et al. J Diabetes Sci Technol. 2024 Nov;18(6):1346-1361. doi: 10.1177/19322968241275701. Epub 2024 Oct 6. J Diabetes Sci Technol. 2024. PMID: 39369312 Free PMC article.
METHODS: Diabetes Technology Society (DTS) convened 89 international experts in glucose monitoring to (1) smooth the borders of the Surveillance Error Grid (SEG) zones and create a user-friendly tool-the DTS Error Grid; (2) define five risk zones of clinical point accuracy …
METHODS: Diabetes Technology Society (DTS) convened 89 international experts in glucose monitoring to (1) smooth the borders of the S …
Different routes of administering EW-7197 versus EW-7197HBr for preventing peritoneal adhesion in a rat model.
Zeng CH, Kim SH, Kang JM, Park Y, Won DS, Kim JW, Ryu DS, Shim S, Kim DK, Shin JH, Park JH. Zeng CH, et al. Surgery. 2023 Apr;173(4):1008-1014. doi: 10.1016/j.surg.2022.11.016. Epub 2022 Dec 26. Surgery. 2023. PMID: 36577598
METHODS: After peritoneal adhesion induction, 30 male Sprague-Dawley rats were randomly divided into 5 groups with 6 rats in each: group A, sham control; group B, orally administered 25 mg/kg of EW-7197.HBr for 7 days; group C, locally administered 25 mg/kg of EW-71 …
METHODS: After peritoneal adhesion induction, 30 male Sprague-Dawley rats were randomly divided into 5 groups with 6 rats in each: group A, …
EW-7197 inhibits hepatic, renal, and pulmonary fibrosis by blocking TGF-beta/Smad and ROS signaling.
Park SA, Kim MJ, Park SY, Kim JS, Lee SJ, Woo HA, Kim DK, Nam JS, Sheen YY. Park SA, et al. Cell Mol Life Sci. 2015 May;72(10):2023-39. doi: 10.1007/s00018-014-1798-6. Epub 2014 Dec 9. Cell Mol Life Sci. 2015. PMID: 25487606 Free PMC article.
EW-7197 decreased the expression of collagen, alpha-smooth muscle actin (alpha-SMA), fibronectin, 4-hydroxy-2, 3-nonenal, and integrins in the livers of CCl4 mice and BDL rats, in the lungs of BLM mice, and in the kidneys of UUO mice. Furthermore, EW-7197 ext …
EW-7197 decreased the expression of collagen, alpha-smooth muscle actin (alpha-SMA), fibronectin, 4-hydroxy-2, 3-nonenal, and …
A protocol for a systematic review of electronic early warning/track-and-trigger systems (EW/TTS) to predict clinical deterioration: Focus on automated features, technologies, and algorithms.
Rostam Niakan Kalhori S, Deserno TM, Haghi M, Ganapathy N. Rostam Niakan Kalhori S, et al. PLoS One. 2023 Mar 15;18(3):e0283010. doi: 10.1371/journal.pone.0283010. eCollection 2023. PLoS One. 2023. PMID: 36920960 Free PMC article.
BACKGROUND: This is a systematic review protocol to identify automated features, applied technologies, and algorithms in the electronic early warning/track and triage system (EW/TTS) developed to predict clinical deterioration (CD). METHODOLOGY: This study will be conducte …
BACKGROUND: This is a systematic review protocol to identify automated features, applied technologies, and algorithms in the electronic earl …
EW-7197, an activin-like kinase 5 inhibitor, suppresses granulation tissue after stent placement in rat esophagus.
Jun EJ, Park JH, Tsauo J, Yang SG, Kim DK, Kim KY, Kim MT, Yoon SH, Lim YJ, Song HY. Jun EJ, et al. Gastrointest Endosc. 2017 Jul;86(1):219-228. doi: 10.1016/j.gie.2017.01.013. Epub 2017 Jan 27. Gastrointest Endosc. 2017. PMID: 28137596
Group A (n = 20) received vehicle-treated control for 4 weeks. Group B (n = 20) received 20 mg/kg/day EW-7197 for 4 weeks. Group C (n = 10) received 20 mg/kg/day EW-7197 for 4 weeks followed by vehicle-treated control for 4 weeks. ...CONCLUSIONS: EW-7197 supp …
Group A (n = 20) received vehicle-treated control for 4 weeks. Group B (n = 20) received 20 mg/kg/day EW-7197 for 4 weeks. Group C (n …
Metabolome-wide association identifies ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations.
Sadhu N, Dalan R, Jain PR, Lee CJM, Pakkiri LS, Tay KY, Mina TH, Low D, Min Y, Ackers-Johnson M, Thi TT, Kota VG, Shi Y, Liu Y, Yu H, Lai V, Yang Y, Tay D, Ng HK, Wang X, Wong KE, Lam M, Guan XL, Bertin N, Wong E, Best J, Sarangarajan R, Elliott P, Riboli E, Lee J, Lee ES, Ngeow J, Tan P, Cheung C, Drum CL, Foo RS, Michelotti GA, Yu H, Sheridan PA, Loh M, Chambers JC. Sadhu N, et al. Nat Cardiovasc Res. 2025 May;4(5):567-583. doi: 10.1038/s44161-025-00638-w. Epub 2025 May 13. Nat Cardiovasc Res. 2025. PMID: 40360795
We validated FDX1 as a regulator of 3BH5C synthesis in hepatocytes and macrophages and demonstrated its role in cholesterol efflux in macrophages and aortic smooth muscle cells, using knockout and overexpression models....
We validated FDX1 as a regulator of 3BH5C synthesis in hepatocytes and macrophages and demonstrated its role in cholesterol efflux in macrop …
75 results