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1959 1
1960 1
1964 1
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1966 2
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1968 7
1969 10
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1971 7
1972 8
1973 7
1974 10
1975 48
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1977 34
1978 25
1979 29
1980 57
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1982 43
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1989 67
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1994 65
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1996 90
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1998 90
1999 111
2000 125
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2002 132
2003 154
2004 156
2005 194
2006 179
2007 197
2008 206
2009 245
2010 232
2011 260
2012 299
2013 276
2014 348
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10,910 results

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Page 1
SPRITE: a genome-wide method for mapping higher-order 3D interactions in the nucleus using combinatorial split-and-pool barcoding.
Quinodoz SA, Bhat P, Chovanec P, Jachowicz JW, Ollikainen N, Detmar E, Soehalim E, Guttman M. Quinodoz SA, et al. Nat Protoc. 2022 Jan;17(1):36-75. doi: 10.1038/s41596-021-00633-y. Epub 2022 Jan 10. Nat Protoc. 2022. PMID: 35013617 Free PMC article. Review.
SPRITE works by cross-linking interacting DNA, RNA and protein molecules and then mapping DNA-DNA spatial arrangements through an iterative split-and-pool barcoding method. All DNA molecules within a cross-linked complex are barcoded by repeatedly splitting complexe …
SPRITE works by cross-linking interacting DNA, RNA and protein molecules and then mapping DNA-DNA spatial arrangements through an iterative …
Dynamic split G-quadruplex programmed reversible nanodevice.
Yu Y , Zhou Y , Zhu M , Su G , Deng H , Chen W , Peng H . Yu Y , et al. Chem Commun (Camb). 2019 Jan 2;55(3):389-392. doi: 10.1039/c8cc08744j. Chem Commun (Camb). 2019. PMID: 30540300
We propose a dynamic nanodevice based on a split G-quadruplex (G4). By splitting it apart, we can successfully decouple the G-tetrad formation from external stimuli, greatly expanding the stimulus for G4 based devices. ...
We propose a dynamic nanodevice based on a split G-quadruplex (G4). By splitting it apart, we can successfully decouple …
Toward a Rational Approach to Design Split G-Quadruplex Probes.
Connelly RP, Verduzco C, Farnell S, Yishay T, Gerasimova YV. Connelly RP, et al. ACS Chem Biol. 2019 Dec 20;14(12):2701-2712. doi: 10.1021/acschembio.9b00634. Epub 2019 Oct 22. ACS Chem Biol. 2019. PMID: 31599573 Free PMC article.
Systematic efforts in probe optimization resulted in their improved binding affinity, turn-on ratios, and ability to discriminate single nucleotide substitutions (SNSs). The use of split (or multicomponent) probes is a promising strategy to improve probe selectivity and en …
Systematic efforts in probe optimization resulted in their improved binding affinity, turn-on ratios, and ability to discriminate single nuc …
Unifying Splitting.
Ebner G, Blanchette J, Tourret S. Ebner G, et al. J Autom Reason. 2023;67(2):16. doi: 10.1007/s10817-023-09660-8. Epub 2023 Apr 28. J Autom Reason. 2023. PMID: 37131534 Free PMC article.
And how does it relate to other splitting architectures? To answer these questions, we present a unifying framework that extends a saturation calculus (e.g., superposition) with splitting and that embeds the result in a prover guided by a SAT solver. ...Vario …
And how does it relate to other splitting architectures? To answer these questions, we present a unifying framework that extends a sa …
Identification and Classification of Functional Split G-Quadruplexes Using Machine Learning-Guided Activity Screening.
Das P, Das A, Debnath M. Das P, et al. ACS Appl Bio Mater. 2025 Jun 16;8(6):4844-4854. doi: 10.1021/acsabm.5c00215. Epub 2025 May 25. ACS Appl Bio Mater. 2025. PMID: 40415306
Split G-quadruplexes are considered excellent tools for biosensing and diagnostics, but splitting G-quadruplexes may often lead to a loss of function, limiting their effectiveness. This study aims to identify and classify functional split G …
Split G-quadruplexes are considered excellent tools for biosensing and diagnostics, but splitting G-quadruplexes …
Chiral Split Magnon in Altermagnetic MnTe.
Liu Z, Ozeki M, Asai S, Itoh S, Masuda T. Liu Z, et al. Phys Rev Lett. 2024 Oct 11;133(15):156702. doi: 10.1103/PhysRevLett.133.156702. Phys Rev Lett. 2024. PMID: 39454157
Altermagnetism is a newly recognized magnetic class named after the alternating spin polarizations in both real and reciprocal spaces. Like the spin splitting of electronic bands, the magnon bands in altermagnets are predicted to exhibit alternating chiral splitting …
Altermagnetism is a newly recognized magnetic class named after the alternating spin polarizations in both real and reciprocal spaces. Like …
Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons.
Jin S, Zhu Z, Li Y, Zhang S, Liu Y, Li D, Li Y, Luo Y, Cheng Z, Zhao KT, Gao Q, Yang G, Li H, Liang R, Zhang R, Qiu JL, Zhang YE, Liu JG, Gao C. Jin S, et al. Cell. 2025 Oct 30;188(22):6283-6300.e22. doi: 10.1016/j.cell.2025.09.004. Epub 2025 Sep 29. Cell. 2025. PMID: 41027434
The cryoelectron microscopy (cryo-EM) structure of LaTranC from Lawsonibacter sp. closely resembles that of the ISDra2 TnpB complex; however, unlike a single-molecule reRNA, the LaTranC guide RNA is functionally split into a tracrRNA and crRNA. An engineered RNA split …
The cryoelectron microscopy (cryo-EM) structure of LaTranC from Lawsonibacter sp. closely resembles that of the ISDra2 TnpB complex; however …
Split-Protein Therapeutic Platforms: Identifying Binder Pairs.
Nervig CS, Gustat JR, Owen SC. Nervig CS, et al. Methods Mol Biol. 2024;2720:75-84. doi: 10.1007/978-1-0716-3469-1_5. Methods Mol Biol. 2024. PMID: 37775658
A promising approach to overcome such toxicity is to create conditionally active constructs by splitting the therapeutic protein into two, or more, inactive fragments and by fusing these fragments to binders (e.g., antibodies) that target distinct epitopes on a cell …
A promising approach to overcome such toxicity is to create conditionally active constructs by splitting the therapeutic protein into …
Split nerve grafting.
Eberhard D, Millesi H. Eberhard D, et al. J Reconstr Microsurg. 1996 Feb;12(2):71-6. doi: 10.1055/s-2007-1006456. J Reconstr Microsurg. 1996. PMID: 8656403
Twenty-five patients with severe brachial plexus lesions (having a rather poor prognosis in general), were subjected to a variety of split nerve graft procedures, with 22 achieving useful functional recovery. Thirty-eight nerves were reconstructed, with 32 of them achievin …
Twenty-five patients with severe brachial plexus lesions (having a rather poor prognosis in general), were subjected to a variety of spli …
A split cytosine deaminase architecture enables robust inducible base editing.
Long J, Liu N, Tang W, Xie L, Qin F, Zhou L, Tao R, Wang Y, Hu Y, Jiao Y, Li L, Jiang L, Qu J, Chen Q, Yao S. Long J, et al. FASEB J. 2021 Dec;35(12):e22045. doi: 10.1096/fj.202100123R. FASEB J. 2021. PMID: 34797942
In the guidance of structural information, we designed four split-human APOBEC3A (A3A) -BE3 base editors in which these A3A deaminase enzymes were split at sites that were opposite to the protein-nucleotide interface. ...Among these split editors, splicing at …
In the guidance of structural information, we designed four split-human APOBEC3A (A3A) -BE3 base editors in which these A3A deaminase …
10,910 results
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