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1,077 results

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Page 1
Thrombin Activatable Fibrinolysis Inhibitor (TAFI): An Updated Narrative Review.
Sillen M, Declerck PJ. Sillen M, et al. Int J Mol Sci. 2021 Apr 1;22(7):3670. doi: 10.3390/ijms22073670. Int J Mol Sci. 2021. PMID: 33916027 Free PMC article. Review.
Thrombin activatable fibrinolysis inhibitor (TAFI), a proenzyme, is converted to a potent attenuator of the fibrinolytic system upon activation by thrombin, plasmin, or the thrombin/thrombomodulin complex. ...This review aims at providing a general overview on the biochemi …
Thrombin activatable fibrinolysis inhibitor (TAFI), a proenzyme, is converted to a potent attenuator of the fibrinolytic system upon …
TAFI deficiency causes maladaptive vascular remodeling after hemophilic joint bleeding.
Wyseure T, Yang T, Zhou JY, Cooke EJ, Wanko B, Olmer M, Agashe R, Morodomi Y, Behrendt N, Lotz M, Morser J, von Drygalski A, Mosnier LO. Wyseure T, et al. JCI Insight. 2019 Oct 3;4(19):e128379. doi: 10.1172/jci.insight.128379. JCI Insight. 2019. PMID: 31465300 Free PMC article.
Here, hemophilia A (factor VIII-deficient; FVIII-deficient) mice or TAFI-deficient mice with transient (antibody-induced) hemophilia A were used to determine the role of FVIII and TAFI in vascular remodeling after joint bleeding. ...TAFI-overexpression in FVI …
Here, hemophilia A (factor VIII-deficient; FVIII-deficient) mice or TAFI-deficient mice with transient (antibody-induced) hemophilia …
Thrombin activatable fibrinolysis inhibitor (TAFI)--how does thrombin regulate fibrinolysis?
Bouma BN, Mosnier LO. Bouma BN, et al. Ann Med. 2006;38(6):378-88. doi: 10.1080/07853890600852898. Ann Med. 2006. PMID: 17008302 Review.
Thrombin plays a central role in this process, it not only forms the clot but it is also involved in stabilizing the clot by activating thrombin activatable fibrinolysis inhibitor (TAFI). Activated TAFI protects the fibrin clot against lysis. Here we will discuss th …
Thrombin plays a central role in this process, it not only forms the clot but it is also involved in stabilizing the clot by activating thro …
Thrombin activatable fibrinolysis inhibitor (TAFI): a molecular link between coagulation and fibrinolysis.
Miljić P, Heylen E, Willemse J, Djordjević V, Radojković D, Colović M, Elezović I, Hendriks D. Miljić P, et al. Srp Arh Celok Lek. 2010 Jan;138 Suppl 1:74-8. doi: 10.2298/sarh10s1074m. Srp Arh Celok Lek. 2010. PMID: 20229688 Free article. Review.
The antifibrinolytic function of TAFI mostly depends on TAFI concentration, the rate of its activation and the half-life of TAFIa in plasma. Changes in thrombin generation can have a profound effect on the rate of TAFI activation, and consequently on the rate …
The antifibrinolytic function of TAFI mostly depends on TAFI concentration, the rate of its activation and the half-life of TA …
Thrombin-activatable fibrinolysis inhibitor (TAFI, plasma procarboxypeptidase B, procarboxypeptidase R, procarboxypeptidase U).
Bouma BN, Meijers JC. Bouma BN, et al. J Thromb Haemost. 2003 Jul;1(7):1566-74. doi: 10.1046/j.1538-7836.2003.00329.x. J Thromb Haemost. 2003. PMID: 12871292 Free article. Review.
Activated TAFI (TAFIa) downregulates fibrinolysis by the removal of carboxy-terminal lysines from fibrin. ...However, it cannot be ruled out that TAFI has other, as yet undefined, functions in biology....
Activated TAFI (TAFIa) downregulates fibrinolysis by the removal of carboxy-terminal lysines from fibrin. ...However, it cannot be ru …
[TAFI--thrombin activated fibrinolysis inhibitor ].
Hryszko T, Małyszko J, Brzósko S, Myśliwiec M. Hryszko T, et al. Przegl Lek. 2001;58(3):136-8. Przegl Lek. 2001. PMID: 11475860 Review. Polish.
This is a review of literature data concerning Thrombin Activatable Fibrinolysis Inhibitor (TAFI) and its role in haemostatic system in vitro and in vivo. This is the glycoprotein, which was identified recently by three independent groups of researchers. TAFI is con …
This is a review of literature data concerning Thrombin Activatable Fibrinolysis Inhibitor (TAFI) and its role in haemostatic system …
Thrombin-activatable fibrinolysis inhibitor (TAFI) deficient mice.
Nagashima M, Yin ZF, Broze GJ Jr, Morser J. Nagashima M, et al. Front Biosci. 2002 Feb 1;7:d556-68. doi: 10.2741/A794. Front Biosci. 2002. PMID: 11815293 Review.
In order to examine the physiological role of thrombin-activatable fibrinolysis inhibitor (TAFI), we generated homozygous TAFI deficient mice by targeted gene disruption. Intercrossing of heterozygous TAFI mice showed that TAFI mice were born in the ex …
In order to examine the physiological role of thrombin-activatable fibrinolysis inhibitor (TAFI), we generated homozygous TAFI …
Thrombin-activatable fibrinolysis inhibitor (TAFI, plasma procarboxypeptidase B, procarboxypeptidase R, procarboxypeptidase U).
Bouma BN, Marx PF, Mosnier LO, Meijers JC. Bouma BN, et al. Thromb Res. 2001 Mar 1;101(5):329-54. doi: 10.1016/s0049-3848(00)00411-4. Thromb Res. 2001. PMID: 11297751 Review.
In this overview, the protein will be referred to as TAFI. TAFI is a procarboxypeptidase and a member of the family of metallocarboxypeptidases. ...In this review, we will describe the properties of basic carboxypeptidases with the emphasis on the role of TAFI …
In this overview, the protein will be referred to as TAFI. TAFI is a procarboxypeptidase and a member of the family of metallo …
Thrombin activatable fibrinolysis inhibitor (TAFI): a role in pre-eclampsia?
Dusse LM, Cooper AJ, Lwaleed BA. Dusse LM, et al. Clin Chim Acta. 2007 Mar;378(1-2):1-6. doi: 10.1016/j.cca.2006.10.014. Epub 2006 Oct 26. Clin Chim Acta. 2007. PMID: 17184758 Review.
Few studies have investigated pro-TAFI/TAFIa in normal or complicated pregnancy but contrasting results were reported. Understanding the role of pro-TAFI/TAFIa in the pathogenesis of P-Ec can hold great promise for improving P-Ec management. In this context, a large …
Few studies have investigated pro-TAFI/TAFIa in normal or complicated pregnancy but contrasting results were reported. Understanding …
A role for procarboxypepidase U (TAFI) in thrombosis.
Willemse JL, Hendriks DF. Willemse JL, et al. Front Biosci. 2007 Jan 1;12:1973-87. doi: 10.2741/2203. Front Biosci. 2007. PMID: 17127436 Review.
In contrast, pathologic consequences of imbalance manifest tendencies of bleeding or thrombosis. Procarboxypeptidase U (proCPU, TAFI) is recognized as an important link between the coagulation system and fibrinolysis. ...
In contrast, pathologic consequences of imbalance manifest tendencies of bleeding or thrombosis. Procarboxypeptidase U (proCPU, TAFI) …
1,077 results