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Review
. 2024 Feb;29(1-2):22-44.
doi: 10.1007/s10495-023-01905-6. Epub 2023 Nov 24.

Necroptosis inhibitors: mechanisms of action and therapeutic potential

Yingbo Zhou  1 , Zhangtao Cai  1 , Yijia Zhai  1 , Jintao Yu  1 , Qiujing He  2 , Yuan He  3 , Siriporn Jitkaew  4 , Zhenyu Cai  5   6
Affiliations
Review

Necroptosis inhibitors: mechanisms of action and therapeutic potential

Yingbo Zhou et al. Apoptosis. 2024 Feb.

Abstract

Necroptosis is a type of programmed cell death that is morphologically similar to necrosis. This type of cell death is involved in various pathophysiological disorders, including inflammatory, neurodegenerative, infectious, and malignant diseases. Receptor-interacting protein kinase 1 (RIPK1), RIPK3, and mixed lineage kinase domain-like protein (MLKL) pseudokinase constitute the core components of the necroptosis signaling pathway and are considered the most promising targets for therapeutic intervention. The discovery and characterization of necroptosis inhibitors not only accelerate our understanding of the necroptosis signaling pathway but also provide important drug candidates for the treatment of necroptosis-related diseases. Here, we will review recent research progress on necroptosis inhibitors, mechanisms of action and their potential applications for disease treatment.

Keywords: Inhibitors; MLKL; Necroptosis; RIPK1; RIPK3.

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References

    1. Fuchs Y, Steller H (2011) Programmed cell death in animal development and disease. Cell 147(4):742–758 - PubMed - PMC - DOI
    1. Weinlich R, Oberst A, Beere HM et al (2017) Necroptosis in development, inflammation and disease. Nat Rev Mol Cell Biol 18(2):127–136 - PubMed - DOI
    1. Wallach D, Kang TB, Dillon CP et al (2016) Programmed necrosis in inflammation: toward identification of the effector molecules. Science 352(6281):aaf2154 - PubMed - DOI
    1. Pasparakis M, Vandenabeele P (2015) Necroptosis and its role in inflammation. Nature 517(7534):311–320 - PubMed - DOI
    1. Upton JW, Kaiser WJ, Mocarski ES (2019) DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA. Cell Host Microbe 26(4):564 - PubMed - DOI

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