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Page 1
Deubiquitinase OTUD5 as a Novel Protector against 4-HNE-Triggered Ferroptosis in Myocardial Ischemia/Reperfusion Injury.
Liu L, Pang J, Qin D, Li R, Zou D, Chi K, Wu W, Rui H, Yu H, Zhu W, Liu K, Wu X, Wang J, Xu P, Song X, Cao Y, Wang J, Xu F, Xue L, Chen Y. Liu L, et al. Adv Sci (Weinh). 2023 Oct;10(28):e2301852. doi: 10.1002/advs.202301852. Epub 2023 Aug 8. Adv Sci (Weinh). 2023. PMID: 37552043 Free PMC article.
Despite the development of advanced technologies for interventional coronary reperfusion after myocardial infarction, a substantial number of patients experience high mortality due to myocardial ischemia-reperfusion (MI/R) injury. An in-depth understanding of the mechanism …
Despite the development of advanced technologies for interventional coronary reperfusion after myocardial infarction, a substantial number o …
Intermittent theta-burst stimulation improves motor function by inhibiting neuronal pyroptosis and regulating microglial polarization via TLR4/NFκB/NLRP3 signaling pathway in cerebral ischemic mice.
Luo L, Liu M, Fan Y, Zhang J, Liu L, Li Y, Zhang Q, Xie H, Jiang C, Wu J, Xiao X, Wu Y. Luo L, et al. J Neuroinflammation. 2022 Jun 11;19(1):141. doi: 10.1186/s12974-022-02501-2. J Neuroinflammation. 2022. PMID: 35690810 Free PMC article.
CONCLUSIONS: rTMS could alleviate cerebral I/R injury induced locomotor deficits and neuronal pyroptosis by modulating the microglial polarization. It is expected that these data will provide novel insights into the mechanisms of rTMS protecting against cerebral I/R …
CONCLUSIONS: rTMS could alleviate cerebral I/R injury induced locomotor deficits and neuronal pyroptosis by modulating the microglial …
M2 Macrophage-Derived sEV Regulate Pro-Inflammatory CCR2+ Macrophage Subpopulations to Favor Post-AMI Cardiac Repair.
Li L, Cao J, Li S, Cui T, Ni J, Zhang H, Zhu Y, Mao J, Gao X, Midgley AC, Zhu M, Fan G. Li L, et al. Adv Sci (Weinh). 2023 May;10(14):e2202964. doi: 10.1002/advs.202202964. Epub 2023 Mar 22. Adv Sci (Weinh). 2023. PMID: 36950739 Free PMC article.
Here, the authors harvested M2 macrophage-derived sEV (M2(EV) ) from M2-polarized bone-marrow-derived macrophages for intramyocardial injection and recapitulation of sEV-mediated anti-inflammatory activity in ischemic-reperfusion (I/R) injured hearts. Rats and pigs receive …
Here, the authors harvested M2 macrophage-derived sEV (M2(EV) ) from M2-polarized bone-marrow-derived macrophages for intramyocardial inject …
Global coupling of R-loop dynamics with RNA polymerase II modulates gene expression and early development of Drosophila.
Zhang X, Liang SB, Yi Z, Qiao Z, Xu B, Geng H, Wang H, Yin X, Tang M, Ge W, Xu YZ, Liang K, Fan YJ, Chen L. Zhang X, et al. Nucleic Acids Res. 2024 Nov 27;52(21):13110-13127. doi: 10.1093/nar/gkae933. Nucleic Acids Res. 2024. PMID: 39470713 Free PMC article.
R-loops are involved in many biological processes in cells, yet the regulatory principles for R-loops in vivo and their impact on development remain to be explored. Here, we modified the CUT&Tag strategy to profile R-loops in Drosophila at multiple develo …
R-loops are involved in many biological processes in cells, yet the regulatory principles for R-loops in vivo and their impact …
The role of AGEs in muscle ageing and sarcopenia.
Guo Z, Li H, Jiang S, Rahmati M, Su J, Yang S, Wu Y, Li Y, Deng Z. Guo Z, et al. Bone Joint Res. 2025 Mar 4;14(3):185-198. doi: 10.1302/2046-3758.143.BJR-2024-0252.R1. Bone Joint Res. 2025. PMID: 40036085 Free PMC article.
GPATCH4 functions as a regulator of nucleolar R-loops in hepatocellular carcinoma cells.
Zhao YM, Jiang Y, Wang JZ, Cao S, Zhu H, Wang WK, Yu J, Liu J, Hui J. Zhao YM, et al. Nucleic Acids Res. 2025 May 22;53(10):gkaf438. doi: 10.1093/nar/gkaf438. Nucleic Acids Res. 2025. PMID: 40401559 Free PMC article.
GPATCH4 is mainly localized in the nucleolus and helps to unwind RNA loops formed at the rDNA through interacting with DDX21 via its C-terminal intrinsically disordered region. Removal of accumulated R-loops induced by GPATCH4 depletion rescued decreased rRNA transcription …
GPATCH4 is mainly localized in the nucleolus and helps to unwind RNA loops formed at the rDNA through interacting with DDX21 via its C-termi …
Peripheral Inflammation Profile of Cerebellar Ataxia.
Tang C, Deng Q, Yuan X, Ding Z, Hu J, Peng L, Yuan H, Wan N, Gong Y, Ding S, Tan Y, Lei L, Wan L, Qiu R, Tang B, Chen Z, Jiang H. Tang C, et al. Curr Neuropharmacol. 2025;23(10):1276-1286. doi: 10.2174/011570159X379620250225075810. Curr Neuropharmacol. 2025. PMID: 40033511 Free PMC article.
In addition, MLR was significantly corelated with clinical scales, including SARA and ICARS in SCA group as well as UMSARS and FAB in MSA-C group (r>0.3/r<-0.3). CONCLUSION: Significant variation in peripheral inflammatory profiles was firstly identified in Ch …
In addition, MLR was significantly corelated with clinical scales, including SARA and ICARS in SCA group as well as UMSARS and FAB in MSA-C …
Electrocatalytic Hydrogenation of Olefins.
Hu P, Xu W, Tian L, Zhu H, Li F, Qi X, Lu Q. Hu P, et al. Angew Chem Int Ed Engl. 2025 May;64(19):e202501215. doi: 10.1002/anie.202501215. Epub 2025 Mar 10. Angew Chem Int Ed Engl. 2025. PMID: 40024900
In addition, highly regioselective electrocatalytic hydrogenation of olefins (r.r. > 19:1) is demonstrated using PtCl(2) and 2,2'-bipyridine....
In addition, highly regioselective electrocatalytic hydrogenation of olefins (r.r. > 19:1) is demonstrated using PtCl(2) an …
The roles of sclerostin and irisin on bone and muscle of orchiectomized rats.
Zhou BN, Zhang Q, Lin XY, Hu J, Zhao DC, Jiang Y, Xing XP, Li M. Zhou BN, et al. BMC Musculoskelet Disord. 2022 Dec 2;23(1):1049. doi: 10.1186/s12891-022-05982-7. BMC Musculoskelet Disord. 2022. PMID: 36456918 Free PMC article.

Grip strength was positively correlated with femoral trabecular BMD (r = 0.713, P < 0.001) and bone volume/total volume (r = 0.712, P < 0.001) in all rats. The serum sclerostin level was negatively correlated to femoral trabecular BMD (r = -0.508, P = 0

…

Grip strength was positively correlated with femoral trabecular BMD (r = 0.713, P < 0.001) and bone volume/total volume (r

…
Targeted Analysis of Mitochondrial Protein Conformations and Interactions by Endogenous ROS-Triggered Cross-Linker Release.
Zhou W, Chen Y, Fu W, Li X, Xia Y, Zhao Q, Zhao B, Zhang Y, Yang K, Zhang L. Zhou W, et al. Adv Sci (Weinh). 2024 Dec;11(48):e2408462. doi: 10.1002/advs.202408462. Epub 2024 Oct 30. Adv Sci (Weinh). 2024. PMID: 39476196 Free PMC article.
Herein, this work develops the reactive oxygen species (ROS)-responsive cross-linker delivery nanoparticles (R-CDNP) targeting mitochondria. R-CDNP contains mitochondria-targeting module triphenylphosphine, ROS-responsive module thioketal, loading module poly(lactic …
Herein, this work develops the reactive oxygen species (ROS)-responsive cross-linker delivery nanoparticles (R-CDNP) targeting mitoch …
866 results