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. 2023 Oct;241(10):2409-2418.
doi: 10.1007/s00221-023-06693-8. Epub 2023 Aug 29.

Targeting EZH2 regulates the biological characteristics of glioma stem cells via the Notch1 pathway

Guozheng Zhao #  1   2 , Zhitong Deng #  1   3 , Xuetao Li  1 , Hao Wang  1 , Guangliang Chen  1 , Ming Feng  1 , Youxin Zhou  4
Affiliations

Targeting EZH2 regulates the biological characteristics of glioma stem cells via the Notch1 pathway

Guozheng Zhao et al. Exp Brain Res. 2023 Oct.

Abstract

Glioma is the most common malignant brain tumor, and its behavior is closely related to the presence of glioma stem cells (GSCs). We found that the enhancer of zeste homolog 2 (EZH2) is highly expressed in glioma and that its expression is correlated with the prognosis of glioblastoma multiforme (GBM) in two databases: The Cancer Genome Atlas and the Chinese Glioma Genome Atlas. Additionally, EZH2 is known to regulate the stemness-associated gene expression, proliferation, and invasion ability of GSCs, which may be achieved through the activation of the STAT3 and Notch1 pathways. Furthermore, we demonstrated the effect of the EZH2-specific inhibitor GSK126 on GSCs; these results not only corroborate our hypothesis, but also provide a potential novel treatment approach for glioma.

Keywords: EZH2; GSK126; Glioma stem cells; Notch1; STAT3.

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