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Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial.
Menon BK, Buck BH, Singh N, Deschaintre Y, Almekhlafi MA, Coutts SB, Thirunavukkarasu S, Khosravani H, Appireddy R, Moreau F, Gubitz G, Tkach A, Catanese L, Dowlatshahi D, Medvedev G, Mandzia J, Pikula A, Shankar J, Williams H, Field TS, Manosalva A, Siddiqui M, Zafar A, Imoukhuede O, Hunter G, Demchuk AM, Mishra S, Gioia LC, Jalini S, Cayer C, Phillips S, Elamin E, Shoamanesh A, Subramaniam S, Kate M, Jacquin G, Camden MC, Benali F, Alhabli I, Bala F, Horn M, Stotts G, Hill MD, Gladstone DJ, Poppe A, Sehgal A, Zhang Q, Lethebe BC, Doram C, Ademola A, Shamy M, Kenney C, Sajobi TT, Swartz RH; AcT Trial Investigators. Menon BK, et al. Lancet. 2022 Jul 16;400(10347):161-169. doi: 10.1016/S0140-6736(22)01054-6. Epub 2022 Jun 29. Lancet. 2022. PMID: 35779553 Clinical Trial.
Faster Thrombolysis Is Associated With Improved Cognitive Outcomes in Patients With Acute Ischemic Stroke Treated With Alteplase and Tenecteplase: A Substudy of the AcT Trial.
Sujanthan S, Rajkumar G, Dainty KN, Barense M, Lanctot KL, Owen AM, Singh N, Buck BH, Khosravani H, Coutts SB, Almekhlafi M, Appireddy R, Tkach A, Catanese L, Dowlatshahi D, Mandzia J, Pikula A, Williams H, Field TS, Manosalva A, Siddiqui M, Hunter G, Horn M, Bala F, Hill MD, Shamy M, Ganesh A, Sajobi T, Menon BK, Swartz RH; AcT Trial Investigators. Sujanthan S, et al. Stroke. 2025 Oct;56(10):2858-2865. doi: 10.1161/STROKEAHA.125.051670. Epub 2025 Jul 18. Stroke. 2025. PMID: 40677228