Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1999 May 4;18(9):2580-92.
doi: 10.1093/emboj/18.9.2580.

Phenotypic switching in Candida albicans is controlled by a SIR2 gene

J Pérez-Martín  1 , J A Uría, A D Johnson
Affiliations
Comparative Study

Phenotypic switching in Candida albicans is controlled by a SIR2 gene

J Pérez-Martín et al. EMBO J. .

Abstract

We report the cloning of a gene from the human fungal pathogen Candida albicans with sequence and functional similarity to the Saccharomyces cerevisiae SIR2 gene. Deletion of the gene in C. albicans produces a dramatic phenotype: variant colony morphologies arise at frequencies as high as 1 in 10. The morphologies resemble those described previously as part of a phenotypic switching system proposed to contribute to pathogenesis. Deletion of SIR2 also produces a high frequency of karyotypic changes. These and other results are consistent with a model whereby Sir2 controls phenotypic switching and chromosome stability in C.albicans by organizing chromatin structure.

PubMed Disclaimer

References

    1. Infect Immun. 1979 Oct;26(1):348-54 - PubMed
    1. Trends Genet. 1993 Feb;9(2):61-5 - PubMed
    1. Science. 1985 Nov 8;230(4726):666-9 - PubMed
    1. J Gen Microbiol. 1985 Aug;131(8):2107-13 - PubMed
    1. Bioessays. 1986 Jul;5(1):5-11 - PubMed

Publication types

MeSH terms

Associated data