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. 2003 Feb;28(2):66-9.
doi: 10.1016/S0968-0004(02)00013-0.

The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase

Myriam Roussigne  1 , Sophia Kossida, Anne-Claire Lavigne, Thomas Clouaire, Vincent Ecochard, Alexandra Glories, François Amalric, Jean-Philippe Girard
Affiliations

The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase

Myriam Roussigne et al. Trends Biochem Sci. 2003 Feb.

Abstract

We have identified a novel evolutionarily conserved protein motif - designated the THAP domain - that defines a new family of cellular factors. We have found that the THAP domain presents striking similarities with the site-specific DNA-binding domain (DBD) of Drosophila P element transposase, including a similar size, N-terminal location, and conservation of the residues that define the THAP motif, such as the C2CH signature (Cys-Xaa(2-4)-Cys-Xaa(35-50)-Cys-Xaa(2)-His). Our results suggest that the THAP domain is a novel example of a DBD that is shared between cellular proteins and transposases from mobile genomic parasites.

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