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Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.
Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3859-63. doi: 10.1073/pnas.96.7.3859.
Proc Natl Acad Sci U S A. 1999.
PMID: 10097128
Free PMC article.
Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication.
Nakayama K, Nagahama H, Minamishima YA, Matsumoto M, Nakamichi I, Kitagawa K, Shirane M, Tsunematsu R, Tsukiyama T, Ishida N, Kitagawa M, Nakayama K, Hatakeyama S.
Nakayama K, et al.
EMBO J. 2000 May 2;19(9):2069-81. doi: 10.1093/emboj/19.9.2069.
EMBO J. 2000.
PMID: 10790373
Free PMC article.
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