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. 2000 Dec 1;275(48):38005-11.
doi: 10.1074/jbc.M005948200.

Roles of two homotetrameric kinesins in sea urchin embryonic cell division

K K Chui  1 , G C Rogers, A M Kashina, K P Wedaman, D J Sharp, D T Nguyen, F Wilt, J M Scholey
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Free article

Roles of two homotetrameric kinesins in sea urchin embryonic cell division

K K Chui et al. J Biol Chem. .
Free article

Abstract

To improve our understanding of the roles of microtubule cross-linking motors in mitosis, we analyzed two sea urchin embryonic kinesin-related proteins. It is striking to note that both of these proteins behave as homotetramers, but one behaves as a more compact molecule than the other. These observations suggest that these two presumptive motors could cross-link microtubules into bundles with different spacing. Both motors localize to mitotic spindles, and antibody microinjection experiments suggest that they have mitotic functions. Thus, one of these kinesin-related proteins may cross-link spindle microtubules into loose bundles that are "tightened" by the other.

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