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. 2018 May;15(5):e1700560.
doi: 10.1002/cbdv.201700560. Epub 2018 May 6.

Terpenes from Euphorbia antiquorum and Their in Vitro Anti-HIV Activity

Miao Dong  1 , Xuan-Qin Chen  1 , Chin-Ho Chen  2 , Rong-Tao Li  1
Affiliations

Terpenes from Euphorbia antiquorum and Their in Vitro Anti-HIV Activity

Miao Dong et al. Chem Biodivers. 2018 May.

Abstract

Three new compounds (1 - 3), including two euphane type triterpenes, 24,24-dimethoxy-25,26,27-trinoreuphan-3β-ol (1) and (24S)-24-hydroperoxyeupha-8,25-dien-3β-ol (2), and an ent-atisine diterpene, ent-atisane-3α,16α,17-triol (3), were isolated from an acetone extract of the stems of Euphorbia antiquorum, together with eight known diterpenes (4 - 11). The structures of compounds (1 - 11) were elucidated using NMR and MS spectroscopic methods. Compound 7 showed moderate activity against HIV-1 replication in vitro (EC50 = 1.38 μm).

Keywords: Euphorbia antiquorum; anti-HIV; diterpenes; triterpenes.

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