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Comparative Study
. 2001 May 20;17(8):775-81.
doi: 10.1089/088922201750237059.

Characterization and phylogenetic analysis of South African HIV-1 subtype C accessory genes

T J Scriba  1 , F K Treurnicht, M Zeier, S Engelbrecht, E J van Rensburg
Affiliations
Comparative Study

Characterization and phylogenetic analysis of South African HIV-1 subtype C accessory genes

T J Scriba et al. AIDS Res Hum Retroviruses. .

Abstract

To acquire new knowledge about the genetic diversity and potential impact on vaccine strategies of HIV-1 subtype C in South Africa, we have characterized the vif, vpr, and vpu genes of 15 isolates. Phylogenetic analysis of the genomic fragment encompassing these genes revealed subtype C subclusters, suggesting close relatedness with subtype C strains from other geographic locations and excluded isolation of South African strains. The putative T155 phosphorylation site in the C terminal of Vif was absent in all subtype C sequences. Variation in the predicted amino acid sequences of the three genes further showed strong correlation with other subtype C sequences.

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