Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 May 1;234(1):43-9.
doi: 10.1016/j.femsle.2004.03.011.

Molecular characterization and analysis of the operon encoding the antifungal lipopeptide bacillomycin D

Anne-Laure Moyne  1 , Thomas E Cleveland, Sadik Tuzun
Affiliations

Molecular characterization and analysis of the operon encoding the antifungal lipopeptide bacillomycin D

Anne-Laure Moyne et al. FEMS Microbiol Lett. .

Abstract

Bacillus subtilis AU195 produces bacillomycin D, a cyclic lipopeptide that is an inhibitor of the aflatoxin producing fungus Aspergillus flavus. Sequence analysis of the bacillomycin D operon revealed four ORFs with the structural organization of the peptide synthetases. Disruption of ORF 2, which links the amino acid moiety to the b-amino fatty acid, resulted in the loss of antifungal activity. By comparing the sequence of bacillomycin D, iturin A and mycosubtilin operons, our results showed that intergenic module replacement have occurred between B. subtilis lipopeptide synthetases including the iturin family and the plipastatin and fengycin family.

PubMed Disclaimer

Publication types

MeSH terms

Associated data

LinkOut - more resources