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. 2004 Sep;20(9):1032-5.
doi: 10.1089/aid.2004.20.1032.

Molecular characterization of HIV type 1 isolates from untreated patients of Mumbai (Bombay), India, and detection of rare resistance mutations

Alaka Deshpande  1 , Patricia Recordon-Pinson, Ranjana Deshmukh, Muriel Faure, Valérie Jauvin, Isabelle Garrigue, Marie-Edith Lafon, Hervé J Fleury
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Molecular characterization of HIV type 1 isolates from untreated patients of Mumbai (Bombay), India, and detection of rare resistance mutations

Alaka Deshpande et al. AIDS Res Hum Retroviruses. 2004 Sep.

Abstract

The molecular characterization of HIV-1 isolates in drug-naive cases in the early stages of HIV disease was studied in 128 cases from Mumbai (Bombay), India. Subtype C was largely predominant followed by A-C intersubtype recombinants, one subtype A and one CRF01 AE. Compared to subtype B, subtype C exhibited an important polymorphism; the percentages of substitutions could reach more than 90%. Two isolates showed M184V substitution the reverse transcriptase indicating resistance to 3TC.

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