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14,584 results

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Page 1
Showing results for analogous z
Search for Akalogoun Z instead (1 results)
A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings.
Véniant MM, Lu SC, Atangan L, Komorowski R, Stanislaus S, Cheng Y, Wu B, Falsey JR, Hager T, Thomas VA, Ambhaikar M, Sharpsten L, Zhu Y, Kurra V, Jeswani R, Oberoi RK, Parnes JR, Honarpour N, Neutel J, Strande JL. Véniant MM, et al. Nat Metab. 2024 Feb;6(2):290-303. doi: 10.1038/s42255-023-00966-w. Epub 2024 Feb 5. Nat Metab. 2024. PMID: 38316982 Free PMC article. Clinical Trial.
AMG 133 (maridebart cafraglutide) is a bispecific molecule engineered by conjugating a fully human monoclonal anti-human GIPR antagonist antibody to two GLP-1 analogue agonist peptides using amino acid linkers. Here, we confirm the GIPR antagonist and GLP-1R agonist activi …
AMG 133 (maridebart cafraglutide) is a bispecific molecule engineered by conjugating a fully human monoclonal anti-human GIPR antagonist ant …
Transcriptional Perturbations of 2,6-Diaminopurine and 2-Aminopurine.
Tan Y, You C, Park J, Kim HS, Guo S, Schärer OD, Wang Y. Tan Y, et al. ACS Chem Biol. 2022 Jul 15;17(7):1672-1676. doi: 10.1021/acschembio.2c00369. Epub 2022 Jun 14. ACS Chem Biol. 2022. PMID: 35700389 Free PMC article.
2,6-Diaminopurine (Z) is a naturally occurring adenine (A) analog that bacteriophages employ in place of A in their genetic alphabet. ...The lack of mutagenic consequence and the presence of a strong blockage effect of Z on transcription suggest a role of …
2,6-Diaminopurine (Z) is a naturally occurring adenine (A) analog that bacteriophages employ in place of A in their genetic al …
2-O-Benzhydryl-3,4-(S)-O-benzyl-idene-d-xylono-1,4-lactone.
Jenkinson SF, Rule SD, Booth KV, Fleet GW, Watkin DJ, Petursson S. Jenkinson SF, et al. Acta Crystallogr Sect E Struct Rep Online. 2008 May 7;64(Pt 6):o1012. doi: 10.1107/S1600536808012567. Acta Crystallogr Sect E Struct Rep Online. 2008. PMID: 21202537 Free PMC article.
X-ray crystallography unequivocally shows that protection of the free hydroxyl group of 3,5-O-benzyl-idene-d-xylono-1,4-lactone with diphenyl-diazo-methane proceeded smoothly to give the title compound, C(25)H(22)O(5), with no accompanying epimerization. Unlike the analogously …
X-ray crystallography unequivocally shows that protection of the free hydroxyl group of 3,5-O-benzyl-idene-d-xylono-1,4-lactone with dipheny …
Studying Z-DNA and B- to Z-DNA transitions using a cytosine analogue FRET-pair.
Dumat B, Larsen AF, Wilhelmsson LM. Dumat B, et al. Nucleic Acids Res. 2016 Jun 20;44(11):e101. doi: 10.1093/nar/gkw114. Epub 2016 Feb 20. Nucleic Acids Res. 2016. PMID: 26896804 Free PMC article.
Moreover, we show how fluorescence spectroscopy and our cytosine analogues can be used to determine rate constants for the B- to Z-DNA transition mechanism. The modified cytosines have little influence on the transition and the FRET pair is thus an easily implemente …
Moreover, we show how fluorescence spectroscopy and our cytosine analogues can be used to determine rate constants for the B- to Z …
Ruthenium-Catalyzed (Z)-Selective Hydroboration of Terminal Alkynes with Naphthalene-1,8-diaminatoborane.
Yamamoto K, Mohara Y, Mutoh Y, Saito S. Yamamoto K, et al. J Am Chem Soc. 2019 Oct 30;141(43):17042-17047. doi: 10.1021/jacs.9b06910. Epub 2019 Sep 18. J Am Chem Soc. 2019. PMID: 31523958
The metal-catalyzed (Z)-selective hydroboration of terminal alkynes is synthetically challenging due to the usually (E)-selective nature of the hydroboration and the formation of the thermodynamically unstable (Z)-isomer. ...Mechanistic studies, particularly the iso …
The metal-catalyzed (Z)-selective hydroboration of terminal alkynes is synthetically challenging due to the usually (E)-selective nat …
Therapy of obesity in women with PCOS using GLP-1 analogues - benefits and limitations [Terapia otylosci u kobiet z PCOS przy zastosowaniu analogow GLP-1 - korzysci i ograniczenia].
Baranowska-Bik A. Baranowska-Bik A. Endokrynol Pol. 2022;73(3):627-643. doi: 10.5603/EP.a2022.0047. Endokrynol Pol. 2022. PMID: 36059178 Free article. Review.
Evidence-based data have unequivocally proven the validity of the use of glucagon-like peptide 1 (GLP-1) analogues in the treatment of overweight/obese patients with PCOS. The result of the GLP-1 therapy is not only a reduction of body weight but also an improvement in ins …
Evidence-based data have unequivocally proven the validity of the use of glucagon-like peptide 1 (GLP-1) analogues in the treatment o …
A new actinomycin Z analogue with an additional oxygen bridge between chromophore and beta-depsipentapeptide from Streptomyces sp. KIB-H714.
Dong M, Cao P, Ma YT, Luo J, Yan Y, Li RT, Huang SX. Dong M, et al. Nat Prod Res. 2019 Jan;33(2):219-225. doi: 10.1080/14786419.2018.1443097. Epub 2018 Mar 2. Nat Prod Res. 2019. PMID: 29495881
Actinomycin Z(6) (1), a new member of the actinomycin family, along with three congeners of the Z-type (Z(1), Z(3), Z(5)) actinomycins, are produced from Streptomyces sp. ...In Z(3) and Z(5), the L-threonine in beta-depsipeptide is …
Actinomycin Z(6) (1), a new member of the actinomycin family, along with three congeners of the Z-type (Z(1), Z( …
Stabilization of Z-DNA by demethylation of thymine bases: 1.3-A single-crystal structure of d(m5CGUAm5CG).
Zhou GW, Ho PS. Zhou GW, et al. Biochemistry. 1990 Aug 7;29(31):7229-36. doi: 10.1021/bi00483a010. Biochemistry. 1990. PMID: 2207101
These solvent interactions were not observed in the previously published Z-DNA structure of the analogous d(m5CGTAm5CG) sequence. A comparison of the thymine and uridine structures supports our prediction that demethylation of thymine bases helps to stabilize Z …
These solvent interactions were not observed in the previously published Z-DNA structure of the analogous d(m5CGTAm5CG) sequen …
Fluorescent nucleobase analogues for base-base FRET in nucleic acids: synthesis, photophysics and applications.
Bood M, Sarangamath S, Wranne MS, Grøtli M, Wilhelmsson LM. Bood M, et al. Beilstein J Org Chem. 2018 Jan 10;14:114-129. doi: 10.3762/bjoc.14.7. eCollection 2018. Beilstein J Org Chem. 2018. PMID: 29441135 Free PMC article. Review.
Forster resonance energy transfer (FRET) between a donor nucleobase analogue and an acceptor nucleobase analogue, base-base FRET, works as a spectroscopic ruler and protractor. ...The first base-base FRET pair, tC(O)-tC(nitro), has recently been complemented with am …
Forster resonance energy transfer (FRET) between a donor nucleobase analogue and an acceptor nucleobase analogue, base-base FR …
(Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New nucleoside analogues with a broad-spectrum antiviral activity.
Qiu YL, Ksebati MB, Ptak RG, Fan BY, Breitenbach JM, Lin JS, Cheng YC, Kern ER, Drach JC, Zemlicka J. Qiu YL, et al. J Med Chem. 1998 Jan 1;41(1):10-23. doi: 10.1021/jm9705723. J Med Chem. 1998. PMID: 9438017
The Z-isomers were always predominant in these mixtures (Z/E approximately 2/1). Reduction of 26 + 27 and 31 + 32 with DIBALH afforded (Z)- and (E)-methylenecyclopropane alcohols 14 + 16 and 33 + 34. ...Reaction of 33 and 34 with HCO2H led to guanine analo …
The Z-isomers were always predominant in these mixtures (Z/E approximately 2/1). Reduction of 26 + 27 and 31 + 32 with DIBALH …
14,584 results
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