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Randomized trial of anakinra plus zinc vs. prednisone for severe alcohol-associated hepatitis.
Gawrieh S, Dasarathy S, Tu W, Kamath PS, Chalasani NP, McClain CJ, Bataller R, Szabo G, Tang Q, Radaeva S, Barton B, Nagy LE, Shah VH, Sanyal AJ, Mitchell MC; AlcHepNet Investigators. Gawrieh S, et al. J Hepatol. 2024 May;80(5):684-693. doi: 10.1016/j.jhep.2024.01.031. Epub 2024 Feb 10. J Hepatol. 2024. PMID: 38342441 Free PMC article. Clinical Trial.
Serum aryl hydrocarbon receptor activity is associated with survival in patients with alcohol-associated hepatitis.
Yamazaki T, Kouno T, Hsu CL, Hartmann P, Mayo S, Zhang X, Stärkel P, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS Jr, Vargas V, Altamirano J, Caballería J, Shawcross DL, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Bataller R, Schnabl B; AlcHepNet Investigators. Yamazaki T, et al. Hepatology. 2024 Aug 1;80(2):403-417. doi: 10.1097/HEP.0000000000000777. Epub 2024 Feb 20. Hepatology. 2024. PMID: 38377466 Free PMC article.
Natural history and development of a novel composite endpoint in patients with alcohol-associated hepatitis: Data from a prospective multicenter study.
Dasarathy S, Tu W, Welch N, Gawrieh S, Yu Y, Tang Q, Kettler C, Sanyal AJ, Szabo G, Shah VH, Bataller R, Nagy LE, McClain CJ, Chalasani N, Kerr T, Mitchell MC; for AlcHepNet Investigators. Dasarathy S, et al. Hepatology. 2025 Sep 9. doi: 10.1097/HEP.0000000000001513. Online ahead of print. Hepatology. 2025. PMID: 40924794
Acute kidney injury in severe alcohol-associated hepatitis treated with anakinra plus zinc or prednisone.
Patidar KR, Tu W, Cotter TG, Simonetto DA, Asgharpour A, Jan MY, Tang Q, Yu Y, Li Y, Taiwo M, Thevkar Nagesh P, Dasarathy S, Kamath PS, McClain CJ, Chalasani N, Szabo G, Bataller R, Mitchell M, Mehal WZ, Nagy LE, Shah VH, Gawrieh S, Sanyal AJ; AlcHepNet Investigators. Patidar KR, et al. Hepatology. 2025 Apr 1;81(4):1256-1268. doi: 10.1097/HEP.0000000000001019. Epub 2024 Jul 19. Hepatology. 2025. PMID: 39028887 Clinical Trial.
Parental liver disease mortality is associated with unfavorable outcomes in patients with alcohol-associated hepatitis.
Tu W, Gawrieh S, Nephew L, McClain C, Tang Q, Dasarathy S, Vatsalya V, Simonetto DA, Kettler C, Szabo G, Barton B, Yu Y, Kamath PS, Sanyal AJ, Nagy L, Mitchell MC, Liangpunsakul S, Shah VH, Chalasani N, Bataller R; AlcHepNet Investigators. Tu W, et al. Hepatol Commun. 2025 May 23;9(6):e0666. doi: 10.1097/HC9.0000000000000666. eCollection 2025 Jun 1. Hepatol Commun. 2025. PMID: 40408279 Free PMC article.