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. 2024 Jun;195(4):e32962.
doi: 10.1002/ajmg.b.32962. Epub 2023 Nov 9.

Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study protocol

James J Crowley  1   2 , Carolina Cappi  3   4 , Marcos E Ochoa-Panaifo  5 , Renee M Frederick  6 , Minjee Kook  6 , Andrew D Wiese  6 , Diana Rancourt  7 , Elizabeth G Atkinson  8 , Paola Giusti-Rodriguez  9 , Jacey L Anderberg  6 ; Latin American Trans‐ancestry INitiative for OCD genomics; Brazilian Obsessive‐Compulsive Spectrum Disorder Working Group; Jonathan S Abramowitz  10 , Victor R Adorno  11 , Cinthia Aguirre  12 , Gilberto S Alves  13 , Gustavo S Alves  14   15 , NaEshia Ancalade  1 , Alejandro A Arellano Espinosa  16 , Paul D Arnold  17 , Daphne M Ayton  6 , Izabela G Barbosa  18 , Laura Marcela Barón Castano  19 , Cynthia N Barrera  20 , María Celeste Berardo  21 , Dayan Berrones  22 , John R Best  23 , Tim B Bigdeli  24   25 , Christie L Burton  26 , Joseph D Buxbaum  3 , Jennifer L Callahan  27 , Maria Cecília B Carneiro  28 , Sandra L Cepeda  29 , Evelyn Chazelle  21 , Jessica M Chire  30 , Macarena Churruca Munoz  31 , Pamela Claisse Quiroz  32 , Journa Cobite  33 , Jonathan S Comer  34 , Daniel L Costa  4 , Jennifer Crosbie  26   35 , Victor O Cruz  36   37 , Guillermo Dager  38 , Luisa F Daza  19 , Anabel de la Rosa-Gómez  39 , Daniela Del Río  40 , Fernanda Z Delage  41 , Carolina B Dreher  42   43 , Lucila Fay  21 , Tomas Fazio  21 , Ygor A Ferrão  44 , Gabriela M Ferreira  41   45 , Edith G Figueroa  46 , Leonardo F Fontenelle  47   48 , Diego A Forero  49 , Daniele T H Fragoso  41 , Bharathi S Gadad  50 , Sheldon R Garrison  51 , Andres González  52 , Laura D Gonzalez  21 , Marco A González  39 , Polaris Gonzalez-Barrios  53   54 , Wayne K Goodman  6 , Dorothy E Grice  3 , Jerry Guintivano  2 , Daniel G Guttfreund  55 , Andrew G Guzick  6 , Matthew W Halvorsen  1 , Joseph D Hovey  56 , Hailiang Huang  57 , Jonathan Irreño-Sotomonte  58 , Reinhard Janssen-Aguilar  59 , Matias Jensen  60 , Alexandra Z Jimenez Reynolds  6 , Joali Alexandra Juárez Lujambio  61 , Nasim Khalfe  62 , Madison A Knutsen  6   63 , Caleb Lack  64 , Nuria Lanzagorta  65 , Monicke O Lima  4 , Melanie O Longhurst  50 , David A Lozada Martinez  5 , Elba S Luna  36 , Andrea H Marques  66 , Molly S Martinez  67   68 , Maria de Los Angeles Matos  21 , Caitlyn E Maye  6 , Joseph F McGuire  69 , Gabriela Menezes  70 , Charlene Minaya  71 , Tomás Miño  60 , Sara M Mithani  72 , Circe Montes de Oca  73 , Alonso Morales-Rivero  74 , Maria E Moreira-de-Oliveira  70 , Olivia J Morris  6 , Sandra I Muñoz  39 , Zainab Naqqash  23 , Ambar A Núñez Bracho  52 , Belinda E Núñez Bracho  52 , Maria Corina Ochoa Rojas  19 , Luis A Olavarria Castaman  5 , Trinidad Olivos Balmaceda  75 , Iliana Ortega  17 , Darpan I Patel  72 , Ainsley K Patrick  69 , Mariel Paz Y Mino  76   77 , Jose L Perales Orellana  78 , Bárbara Perdigão Stumpf  18 , Tamara Peregrina  73 , Tania Pérez Duarte  20 , Kelly L Piacsek  51 , Maritza Placencia  79 , María Belén Prieto  21 , Lucas C Quarantini  14   80 , Yana Quarantini-Alvim  14   81 , Renato T Ramos  35   82 , Iaroslava C Ramos  82   83 , Vanessa R Ramos  4 , Kesley A Ramsey  69 , Elise V Ray  1 , Margaret A Richter  82   84 , Bradley C Riemann  51 , Juan C Rivas  19   85   86   87 , Maria C Rosario  88 , Camilo J Ruggero  27 , Angel A Ruiz-Chow  74 , Alejandra Ruiz-Velasco  50 , Melisa N Sagarnaga  89 , Aline S Sampaio  14   15   80 , Leonardo C Saraiva  4 , Russell J Schachar  26   35 , Sophie C Schneider  6 , Ethan J Schweissing  6 , Laura D Seligman  56 , Roseli G Shavitt  4 , Keaton J Soileau  6 , S Evelyn Stewart  23   90   91 , Shaina B Storch  92 , Emily R Strouphauer  62 , Vissente Tapia Cuevas  75 , Kiara R Timpano  29 , Beatriz Treviño-de la Garza  93 , Alexie Vallejo-Silva  58 , Javier Vargas-Medrano  50 , María I Vásquez  94 , Guadalupe Vidal Martinez  50 , Saira A Weinzimmer  6 , Mauricio A Yanez  6 , Gwyneth Zai  84   95 , Lina M Zapata-Restrepo  87   96   97 , Luz M Zappa  21   98   99 , Raquel M Zepeda-Burgos  100 , Anthony W Zoghbi  6   101 , Euripedes C Miguel  4 , Carolyn I Rodriguez  102   103 , Mayra C Martinez Mallen  74 , Pablo R Moya  31   104 , Tania Borda  105   106 , María Beatriz Moyano  21   107   108 , Manuel Mattheisen  109   110 , Stacey Pereira  111 , Gabriel Lázaro-Muñoz  112   113 , Karen G Martinez-Gonzalez  53 , Michele T Pato  114 , Humberto Nicolini  115   116 , Eric A Storch  6
Collaborators, Affiliations

Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study protocol

James J Crowley et al. Am J Med Genet B Neuropsychiatr Genet. 2024 Jun.

Abstract

Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, https://www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5000 richly phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.

Keywords: GWAS; Latin American; OCD; genetic; genomic; obsessive‐compulsive disorder.

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Figures

Figure 1
Figure 1
LATINO study sites.
See this image and copyright information in PMC

Update of

  • Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study Protocol.
    Crowley JJ, Cappi C, Ochoa-Panaifo ME, Frederick RM, Kook M, Wiese AD, Rancourt D, Atkinson EG, Giusti-Rodriguez P, Anderberg JL; Latin American Trans-ancestry INitiative for OCD genomics (LATINO), Brazilian Obsessive-Compulsive Spectrum Disorder Working Group (GTTOC); Abramowitz JS, Adorno VR, Aguirre C, Alves GS, Alves GS, Ancalade N, Espinosa AAA, Arnold PD, Ayton DM, Barbosa IG, Castano LMB, Barrera CN, Prieto MB, Berardo MC, Berrones D, Best JR, Bigdeli TB, Burton CL, Callahan JL, Carneiro MCB, Cepeda SL, Chazelle E, Chire JM, Munoz MC, Quiroz PC, Cobite J, Comer JS, Costa DL, Crosbie J, Cruz VO, Dager G, Daza LF, de la Rosa-Gómez A, Del Río D, Delage FZ, Dreher CB, Fay L, Fazio T, Ferrão YA, Ferreira GM, Figueroa EG, Fontenelle LF, Forero DA, Fragoso DT, Gadad BS, Garrison SR, González A, Gonzalez LD, González MA, Gonzalez-Barrios P, Goodman W, Guintivano J, Guttfreund DG, Guzick AG, Halvorsen MW, Hovey JD, Janssen-Aguilar R, Jensen M, Reynolds AZJ, Lujambio JAJ, Khalfe N, Knutsen MA, Lack C, Lanzagorta N, Lima MO, Longhurst MO, Martinez DAL, Luna ES, Marques AH, Martinez M, de Los Angeles Matos M, Maye CE, McGuire JF, Menezes G, Minaya C, Miño T, Mithani SM, de Oca CM, Mora… See abstract for full author list ➔ Crowley JJ, et al. medRxiv [Preprint]. 2023 Feb 26:2023.02.23.23286373. doi: 10.1101/2023.02.23.23286373. medRxiv. 2023. Update in: Am J Med Genet B Neuropsychiatr Genet. 2024 Jun;195(4):e32962. doi: 10.1002/ajmg.b.32962. PMID: 37131804 Free PMC article. Updated. Preprint.

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