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Page 1
Showing results for arc arc
Search for Arca RC instead (1 results)
'Arc'-hitecture of normal cognitive aging.
Myrum C, Moreno-Castilla P, Rapp PR. Myrum C, et al. Ageing Res Rev. 2022 Sep;80:101678. doi: 10.1016/j.arr.2022.101678. Epub 2022 Jul 1. Ageing Res Rev. 2022. PMID: 35781092 Free PMC article. Review.
Arc is an effector immediate-early gene that is critical for forming long-term memories. ...In addition, we raise several outstanding questions, including whether Arc-containing EVs in peripheral blood might provide a noninvasive biomarker for memory-related synapti …
Arc is an effector immediate-early gene that is critical for forming long-term memories. ...In addition, we raise several outstanding …
The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer.
Pastuzyn ED, Day CE, Kearns RB, Kyrke-Smith M, Taibi AV, McCormick J, Yoder N, Belnap DM, Erlendsson S, Morado DR, Briggs JAG, Feschotte C, Shepherd JD. Pastuzyn ED, et al. Cell. 2018 Jan 11;172(1-2):275-288.e18. doi: 10.1016/j.cell.2017.12.024. Cell. 2018. PMID: 29328916 Free PMC article.
However, little is known about Arc's molecular function and evolutionary origins. Here, we show that Arc self-assembles into virus-like capsids that encapsulate RNA. ...Purified Arc capsids are endocytosed and are able to transfer Arc mRNA into the cyt …
However, little is known about Arc's molecular function and evolutionary origins. Here, we show that Arc self-assembles into v …
The Arc gene: Retroviral heritage in cognitive functions.
Kedrov AV, Durymanov M, Anokhin KV. Kedrov AV, et al. Neurosci Biobehav Rev. 2019 Apr;99:275-281. doi: 10.1016/j.neubiorev.2019.02.006. Epub 2019 Feb 14. Neurosci Biobehav Rev. 2019. PMID: 30772431 Review.
However, the precise mechanisms by which Arc mediates these forms of long-term plasticity are unclear. It was recently found that Arc protein is capable of forming capsid-like structures and of transferring its own mRNA to neighboring cells. Moreover, Arc mRN …
However, the precise mechanisms by which Arc mediates these forms of long-term plasticity are unclear. It was recently found that …
Arc ubiquitination in synaptic plasticity.
Mabb AM, Ehlers MD. Mabb AM, et al. Semin Cell Dev Biol. 2018 May;77:10-16. doi: 10.1016/j.semcdb.2017.09.009. Epub 2017 Sep 7. Semin Cell Dev Biol. 2018. PMID: 28890418 Review.
Notably, Arc protein expression abruptly increases and then rapidly decreases following augmented network activity. A large body of work has focused on Arc transcription and translation. Far fewer studies have explored the relevance of Arc protein stability a …
Notably, Arc protein expression abruptly increases and then rapidly decreases following augmented network activity. A large body of w …
Arc - An endogenous neuronal retrovirus?
Shepherd JD. Shepherd JD. Semin Cell Dev Biol. 2018 May;77:73-78. doi: 10.1016/j.semcdb.2017.09.029. Epub 2017 Sep 24. Semin Cell Dev Biol. 2018. PMID: 28941877 Free PMC article. Review.
However, little is known about Arc's evolutionary origins. Recent studies suggest that mammalian Arc originated from a vertebrate lineage of Ty3/gypsy retrotransposons, which are also ancestral to retroviruses. ...This surprising connection raises the intriguing pos …
However, little is known about Arc's evolutionary origins. Recent studies suggest that mammalian Arc originated from a vertebr …
Arc protein, a remnant of ancient retrovirus, forms virus-like particles, which are abundantly generated by neurons during epileptic seizures, and affects epileptic susceptibility in rodent models.
Sibarov DA, Tsytsarev V, Volnova A, Vaganova AN, Alves J, Rojas L, Sanabria P, Ignashchenkova A, Savage ED, Inyushin M. Sibarov DA, et al. Front Neurol. 2023 Jul 7;14:1201104. doi: 10.3389/fneur.2023.1201104. eCollection 2023. Front Neurol. 2023. PMID: 37483450 Free PMC article. Review.
A product of the immediate early gene Arc (Activity-regulated cytoskeleton-associated protein or Arc protein) of retroviral ancestry resides in the genome of all tetrapods for millions of years and is expressed endogenously in neurons. ...Because it modulates excita …
A product of the immediate early gene Arc (Activity-regulated cytoskeleton-associated protein or Arc protein) of retroviral an …
"Arc - A viral vector of memory and synaptic plasticity".
Sullivan KR, Ravens A, Walker AC, Shepherd JD. Sullivan KR, et al. Curr Opin Neurobiol. 2025 Apr;91:102979. doi: 10.1016/j.conb.2025.102979. Epub 2025 Feb 15. Curr Opin Neurobiol. 2025. PMID: 39956025 Review.
Arc capsids are released in extracellular vesicles that mediate intercellular communication. Here, we review Arc's role in synaptic plasticity and propose a model for how Arc mediates memory consolidation via a novel intercellular non-cell autonomous form of …
Arc capsids are released in extracellular vesicles that mediate intercellular communication. Here, we review Arc's role in syn …
Effect of pharmacological manipulations on Arc function.
Yakout DW, Shree N, Mabb AM. Yakout DW, et al. Curr Res Pharmacol Drug Discov. 2020 Dec 24;2:100013. doi: 10.1016/j.crphar.2020.100013. eCollection 2021. Curr Res Pharmacol Drug Discov. 2020. PMID: 34909648 Free PMC article. Review.
Arc levels are controlled through a balance of induction and degradation in an activity-dependent manner. ...We also discuss inflammatory states that regulate Arc....
Arc levels are controlled through a balance of induction and degradation in an activity-dependent manner. ...We also discuss inflamma …
Molecular physiology of Arc/Arg3.1: The oligomeric state hypothesis of synaptic plasticity.
Eriksen MS, Bramham CR. Eriksen MS, et al. Acta Physiol (Oxf). 2022 Nov;236(3):e13886. doi: 10.1111/apha.13886. Epub 2022 Sep 20. Acta Physiol (Oxf). 2022. PMID: 36073248 Free PMC article. Review.
Here, we discuss recent findings on Arc structure-function and regulation of oligomerization that are giving insight into the molecular physiology of Arc. The unique features of mammalian Arc are emphasized, while drawing comparisons with Drosophila Arc …
Here, we discuss recent findings on Arc structure-function and regulation of oligomerization that are giving insight into the molecul …
The Arc of synaptic memory.
Bramham CR, Alme MN, Bittins M, Kuipers SD, Nair RR, Pai B, Panja D, Schubert M, Soule J, Tiron A, Wibrand K. Bramham CR, et al. Exp Brain Res. 2010 Jan;200(2):125-40. doi: 10.1007/s00221-009-1959-2. Epub 2009 Aug 19. Exp Brain Res. 2010. PMID: 19690847 Free PMC article. Review.
Here, we attempt to overview the Arc system spanning from transcriptional regulation of the Arc gene, to dendritic transport, metabolism, and translation of Arc mRNA, to post-translational modification, localization, and degradation of Arc protein. ... …
Here, we attempt to overview the Arc system spanning from transcriptional regulation of the Arc gene, to dendritic transport, …
62,582 results
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