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Page 1
Showing results for amide c
Search for Aride C instead (1 results)
C-terminal amides mark proteins for degradation via SCF-FBXO31.
Muhar MF, Farnung J, Cernakova M, Hofmann R, Henneberg LT, Pfleiderer MM, Denoth-Lippuner A, Kalčic F, Nievergelt AS, Peters Al-Bayati M, Sidiropoulos ND, Beier V, Mann M, Jessberger S, Jinek M, Schulman BA, Bode JW, Corn JE. Muhar MF, et al. Nature. 2025 Feb;638(8050):519-527. doi: 10.1038/s41586-024-08475-w. Epub 2025 Jan 29. Nature. 2025. PMID: 39880951 Free PMC article.
Here, using a semi-synthetic chemical biology approach coupled to cellular assays, we found that C-terminal amide-bearing proteins (CTAPs) are rapidly cleared from human cells. A CRISPR screen identified FBXO31 as a reader of C-terminal amides. ...A co …
Here, using a semi-synthetic chemical biology approach coupled to cellular assays, we found that C-terminal amide-bearing prot …
Amide-Directed C-H Acetoxylation of Cubanes.
Nagasawa S, Iwabuchi Y. Nagasawa S, et al. Chem Pharm Bull (Tokyo). 2025;73(9):783-786. doi: 10.1248/cpb.c25-00449. Chem Pharm Bull (Tokyo). 2025. PMID: 40903292 Free article.
In this study, a palladium-catalyzed, amide-directed C-H acetoxylation of cubanes has been developed. The ortho positions of the amide directing group on cubanes were selectively acetoxylated without any stoichiometric strong bases. ...
In this study, a palladium-catalyzed, amide-directed C-H acetoxylation of cubanes has been developed. The ortho positions of t …
Selective Conversion of Unactivated C-N Amide Bond to C-C bond via Steric and Electronic Resonance Destabilization.
Adebomi V, Wang Y, Sriram M, Raj M. Adebomi V, et al. Org Lett. 2022 Sep 16;24(36):6525-6530. doi: 10.1021/acs.orglett.2c02420. Epub 2022 Sep 6. Org Lett. 2022. PMID: 36067532 Free PMC article.
The chemo- and site-selective reaction at the particular C-N amide bond among a sea of other amides is a significant and long-standing challenge. Although the use of twisted amides has been demonstrated for modifications of inert C-N amide …
The chemo- and site-selective reaction at the particular C-N amide bond among a sea of other amides is a significant an …
Quantifying Amide-Aromatic Interactions at Molecular and Atomic Levels: Experimentally Determined Enthalpic and Entropic Contributions to Interactions of Amide sp(2)O, N, C and sp(3)C Unified Atoms with Naphthalene sp(2)C Atoms in Water.
Zytkiewicz E, Shkel IA, Cheng X, Rupanya A, McClure K, Karim R, Yang S, Yang F, Record MT Jr. Zytkiewicz E, et al. Biochemistry. 2023 Oct 3;62(19):2841-2853. doi: 10.1021/acs.biochem.3c00367. Epub 2023 Sep 11. Biochemistry. 2023. PMID: 37695675
Here, from determinations of favorable effects of 14 amides on naphthalene solubility at 10, 25, and 45 C, we dissect amide-aromatic interaction free energies into enthalpic and entropic contributions and find these vary systematically with amide compo …
Here, from determinations of favorable effects of 14 amides on naphthalene solubility at 10, 25, and 45 C, we dissect amide …
The Close Interaction of a C-F Bond with an Amide Carbonyl: Crystallographic and Spectroscopic Characterization.
Harry SA, Kazim M, Nguyen PM, Zhu A, Xiang MR, Catazaro J, Siegler M, Lectka T. Harry SA, et al. Angew Chem Int Ed Engl. 2022 Aug 22;61(34):e202207966. doi: 10.1002/anie.202207966. Epub 2022 Jul 13. Angew Chem Int Ed Engl. 2022. PMID: 35716396 Free PMC article.
The putative interaction of a C-F bond with an amide carbonyl has been an intriguing topic of interest in this century for reasons spanning basic physical organic chemistry to biochemistry. ...In turn, we also explore Lewis acid coordination, C-F bond promoti …
The putative interaction of a C-F bond with an amide carbonyl has been an intriguing topic of interest in this century for rea …
Biosynthesis of the C-terminal amide in peptide hormones.
Bradbury AF, Smyth DG. Bradbury AF, et al. Biosci Rep. 1987 Dec;7(12):907-16. doi: 10.1007/BF01122123. Biosci Rep. 1987. PMID: 3331120 Review.
Recent developments in the study of peptide amidation are reviewed. The main areas covered are assay procedures, purification of amidating enzymes, co-factors and regulation, mechanism and specificity of the amidating reaction, and multiple forms of the am …
Recent developments in the study of peptide amidation are reviewed. The main areas covered are assay procedures, purification of a …
Twisted Amide-Mediated Peptide Synthesis.
Koyama A, Kuranaga T, Suo T, Morimoto R, Matsumoto T, Kakeya H. Koyama A, et al. Chemistry. 2024 Nov 21;30(65):e202403288. doi: 10.1002/chem.202403288. Epub 2024 Nov 5. Chemistry. 2024. PMID: 39333757
A robust, practical, and sustainable isomerization-suppressed peptide bond formation via acyl sulfonamide, a twisted amide, is disclosed. Tosyl isocyanate and pentafluorobenzyl bromide were applied in combination to activate the peptide C-terminus, which then reacte …
A robust, practical, and sustainable isomerization-suppressed peptide bond formation via acyl sulfonamide, a twisted amide, is disclo …
Transition-Metal-Free Activation of Amide Bond by Arynes.
Miyabe H. Miyabe H. Molecules. 2018 Aug 27;23(9):2145. doi: 10.3390/molecules23092145. Molecules. 2018. PMID: 30150534 Free PMC article. Review.
Highly reactive arynes activate the N-C and C=O bonds of amide groups under transition metal-free conditions. This review highlights the insertion of arynes into the N-C and C=O bonds of the amide group. ...As relative functional groups a …
Highly reactive arynes activate the N-C and C=O bonds of amide groups under transition metal-free conditions. This revi …
C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity.
Merkler DJ. Merkler DJ. Enzyme Microb Technol. 1994 Jun;16(6):450-6. doi: 10.1016/0141-0229(94)90014-0. Enzyme Microb Technol. 1994. PMID: 7764886 Review.
Peptidylglycine alpha-amidating enzyme (alpha-AE) can be used in an in vitro reaction to convert C-terminal glycine-extended peptides to peptide hormones with a C-terminal amino acid amide. Structure-activity data for 45 bioactive peptides show that th …
Peptidylglycine alpha-amidating enzyme (alpha-AE) can be used in an in vitro reaction to convert C-terminal glycine-extended p …
Modulation of Amide Bond Rotamers in 5-Acyl-6,7-dihydrothieno[3,2-c]pyridines.
Lanyon-Hogg T, Ritzefeld M, Masumoto N, Magee AI, Rzepa HS, Tate EW. Lanyon-Hogg T, et al. J Org Chem. 2015 May 1;80(9):4370-7. doi: 10.1021/acs.joc.5b00205. Epub 2015 Apr 9. J Org Chem. 2015. PMID: 25713927 Free article.
Here we demonstrate, using NMR studies and density functional theory modeling of the lowest energy structures of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine derivatives, that the amide E:Z equilibrium is affected by non-covalent interactions between the amide oxy …
Here we demonstrate, using NMR studies and density functional theory modeling of the lowest energy structures of 5-acyl-6,7-dihydrothieno[3, …
94,755 results
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