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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1905 1
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1951 3
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1955 2
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1958 1
1961 1
1962 2
1963 2
1964 1
1965 1
1966 3
1967 4
1968 1
1969 4
1970 6
1971 8
1972 1
1973 1
1974 1
1975 3
1976 2
1977 4
1978 2
1979 2
1980 5
1981 2
1982 1
1983 2
1984 2
1985 2
1986 3
1987 3
1988 1
1989 2
1990 2
1991 3
1992 3
1993 5
1994 2
1995 1
1996 2
1997 1
1998 1
1999 6
2000 5
2001 7
2002 16
2003 9
2004 12
2005 9
2006 14
2007 11
2008 19
2009 14
2010 16
2011 15
2012 22
2013 37
2014 40
2015 31
2016 37
2017 36
2018 40
2019 37
2020 24
2021 35
2022 28
2023 27
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2025 31
2026 1

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616 results

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Page 1
NSD2 methylates AROS to promote SIRT1 activation and regulates fatty acid metabolism-mediated cancer radiotherapy.
Li X, Song D, Chen Y, Huang C, Liu A, Wu Q, She X, Li K, Wan K, Yu C, Qiu C, Liu L, Wang G, Xu F, Wang J, Hu J. Li X, et al. Cell Rep. 2023 Oct 31;42(10):113126. doi: 10.1016/j.celrep.2023.113126. Epub 2023 Sep 26. Cell Rep. 2023. PMID: 37756162 Free article.
Here, we show that NSD2 promotes fatty acid oxidation (FAO) by methylating AROS (active regulator of SIRT1) at lysine 27, facilitating the physical interaction between AROS and SIRT1. The mutation of lysine 27 to arginine weakens the interaction between AROS …
Here, we show that NSD2 promotes fatty acid oxidation (FAO) by methylating AROS (active regulator of SIRT1) at lysine 27, facilitatin …
SIRT1 activated by AROS sensitizes glioma cells to ferroptosis via induction of NAD+ depletion-dependent activation of ATF3.
Chen X, Wang Z, Li C, Zhang Z, Lu S, Wang X, Liang Q, Zhu X, Pan C, Wang Q, Ji Z, Wang Y, Piao M, Chi G, Ge P. Chen X, et al. Redox Biol. 2024 Feb;69:103030. doi: 10.1016/j.redox.2024.103030. Epub 2024 Jan 3. Redox Biol. 2024. PMID: 38181705 Free PMC article.
Finally, we found RSL3 activated SIRT1 by inducing reactive oxygen species-dependent upregulation of AROS. Together, our study revealed SIRT1 activated by AROS sensitizes glioma cells to ferroptosis via activation of ATF3-dependent inhibition of SLC7A11 and GPX4....
Finally, we found RSL3 activated SIRT1 by inducing reactive oxygen species-dependent upregulation of AROS. Together, our study reveal …
Ageing in the musculoskeletal system.
Roberts S, Colombier P, Sowman A, Mennan C, Rölfing JH, Guicheux J, Edwards JR. Roberts S, et al. Acta Orthop. 2016 Dec;87(sup363):15-25. doi: 10.1080/17453674.2016.1244750. Epub 2016 Oct 17. Acta Orthop. 2016. PMID: 27748151 Free PMC article. Review.
This review covers the cellular constituents that make up some key components of the musculoskeletal system and summarizes discussion from the 2015 Aarhus Regenerative Orthopaedic Symposium (AROS) (Regeneration in the Ageing Population) about how each particular cell type …
This review covers the cellular constituents that make up some key components of the musculoskeletal system and summarizes discussion from t …
Primary prevention of cardiovascular disease with a Mediterranean diet.
Estruch R, Ros E, Salas-Salvadó J, Covas MI, Corella D, Arós F, Gómez-Gracia E, Ruiz-Gutiérrez V, Fiol M, Lapetra J, Lamuela-Raventos RM, Serra-Majem L, Pintó X, Basora J, Muñoz MA, Sorlí JV, Martínez JA, Martínez-González MA; PREDIMED Study Investigators. Estruch R, et al. N Engl J Med. 2013 Apr 4;368(14):1279-90. doi: 10.1056/NEJMoa1200303. Epub 2013 Feb 25. N Engl J Med. 2013. Corrected and republished in: N Engl J Med. 2018 Jun 21;378(25):e34. doi: 10.1056/NEJMoa1800389. Retraction in: N Engl J Med. 2018 Jun 21;378(25):2441-2442. doi: 10.1056/NEJMc1806491. PMID: 23432189 Free article. Corrected and republished. Retracted. Clinical Trial.
SIRT1 and AROS suppress doxorubicin-induced apoptosis via inhibition of GSK3beta activity in neuroblastoma cells.
Kim JW, Yang JH, Kim EJ. Kim JW, et al. Anim Cells Syst (Seoul). 2020 Feb 12;24(1):53-59. doi: 10.1080/19768354.2020.1726461. eCollection 2020. Anim Cells Syst (Seoul). 2020. PMID: 32158616 Free PMC article.
Interestingly, SIRT1 and AROS interacted with GSK3beta and increased inhibitory phosphorylation of GSK3beta on Ser9. Finally, we determined that AROS cooperates with SIRT1 to suppress GSK3beta acetylation. Taken together, our results suggest that SIRT1 and AROS …
Interestingly, SIRT1 and AROS interacted with GSK3beta and increased inhibitory phosphorylation of GSK3beta on Ser9. Finally, we dete …
AROS has a context-dependent effect on SIRT1.
Kokkola T, Suuronen T, Molnár F, Määttä J, Salminen A, Jarho EM, Lahtela-Kakkonen M. Kokkola T, et al. FEBS Lett. 2014 May 2;588(9):1523-8. doi: 10.1016/j.febslet.2014.03.020. Epub 2014 Mar 26. FEBS Lett. 2014. PMID: 24681097 Free article.
The modulation of protein deacetylase SIRT1 has a vast therapeutic potential in treatment of several aging-associated diseases. Active regulator of SIRT1 (AROS) is a small endogenous protein which was originally reported to activate SIRT1 through a direct interaction in ca …
The modulation of protein deacetylase SIRT1 has a vast therapeutic potential in treatment of several aging-associated diseases. Active regul …
The PREDIMED trial, Mediterranean diet and health outcomes: How strong is the evidence?
Guasch-Ferré M, Salas-Salvadó J, Ros E, Estruch R, Corella D, Fitó M, Martínez-González MA; PREDIMED Investigators. Guasch-Ferré M, et al. Nutr Metab Cardiovasc Dis. 2017 Jul;27(7):624-632. doi: 10.1016/j.numecd.2017.05.004. Epub 2017 Jun 10. Nutr Metab Cardiovasc Dis. 2017. PMID: 28684083 Free article. Clinical Trial.
AROS Is a Significant Biomarker for Tumor Aggressiveness in Non-cirrhotic Hepatocellular Carcinoma.
Kwon JH, Ahn KS, Moon YH, Park JY, Wang HJ, Choi KY, Kim G, Joh JW, Lee KG, Kang KJ. Kwon JH, et al. J Korean Med Sci. 2015 Sep;30(9):1253-9. doi: 10.3346/jkms.2015.30.9.1253. Epub 2015 Aug 13. J Korean Med Sci. 2015. PMID: 26339164 Free PMC article.
In the current study, we evaluated an active regulator of SIRT1 (AROS) as a prognostic biomarker in non-cirrhotic HCC. mRNA levels of AROS were measured in tumor and non-tumor tissues obtained from 283 non-cirrhotic HCC patients. ...Kaplan-Meir curve analysis demons …
In the current study, we evaluated an active regulator of SIRT1 (AROS) as a prognostic biomarker in non-cirrhotic HCC. mRNA levels of …
Molecular Mechanism of Sirtuin 1 Modulation by the AROS Protein.
Weiss S, Adolph RS, Schweimer K, DiFonzo A, Meleshin M, Schutkowski M, Steegborn C. Weiss S, et al. Int J Mol Sci. 2022 Oct 23;23(21):12764. doi: 10.3390/ijms232112764. Int J Mol Sci. 2022. PMID: 36361557 Free PMC article.
Sirt1 is regulated through a multitude of mechanisms, including the interaction with regulatory proteins such as the inhibitors Tat and Dbc1 or the activator AROS. Here, we describe a molecular characterization of AROS and how it regulates Sirt1. We find that ARO …
Sirt1 is regulated through a multitude of mechanisms, including the interaction with regulatory proteins such as the inhibitors Tat and Dbc1 …
Cohort profile: design and methods of the PREDIMED study.
Martínez-González MÁ, Corella D, Salas-Salvadó J, Ros E, Covas MI, Fiol M, Wärnberg J, Arós F, Ruíz-Gutiérrez V, Lamuela-Raventós RM, Lapetra J, Muñoz MÁ, Martínez JA, Sáez G, Serra-Majem L, Pintó X, Mitjavila MT, Tur JA, Portillo MP, Estruch R; PREDIMED Study Investigators. Martínez-González MÁ, et al. Int J Epidemiol. 2012 Apr;41(2):377-85. doi: 10.1093/ije/dyq250. Epub 2010 Dec 20. Int J Epidemiol. 2012. PMID: 21172932 No abstract available.
616 results