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. 2023 Oct 3;10(11):ofad484.
doi: 10.1093/ofid/ofad484. eCollection 2023 Nov.

Herpes Simplex Virus Hepatitis in Patients Requiring Intensive Care Unit Admission: A Retrospective, Multicenter, Observational Study

Thomas Frapard  1   2 , Giuliana Amaddeo  3 , Maxens Decavele  4   5 , Paer-Selim Abback  6 , Antoine Gaillet  1   2 , Charlotte Bouzbib  7 , Claire Vanlemmens  8 , Romy Younan  9 , Emmanuel Canet  10   11 , Anne Sophie Moreau  12 , Mathilde Neuville  13 , Elie Azoulay  9 , Alexandre Sitbon  14 , Djamel Mokart  15 , Sylvie Radenne  16 , Armand Abergel  17 , Céline Guichon  18 , Olivier Roux  19 , Agnes Bonadona  20 , Armand Mekontso Dessap  1   2 , Audrey De Jong  21   22 , Jerome Dumortier  23   24 , Nicolas de Prost  1   2 ; GrrrOH and Gref2 study groups
Collaborators, Affiliations

Herpes Simplex Virus Hepatitis in Patients Requiring Intensive Care Unit Admission: A Retrospective, Multicenter, Observational Study

Thomas Frapard et al. Open Forum Infect Dis. .

Abstract

The clinical features and short-term prognosis of patients admitted to the intensive care unit for herpes hepatitis are lacking. Of 33 patients admitted between 2006 and 2022, 22 were immunocompromised, 4 were pregnant women, and 23 died. Sixteen patients developed a hemophagocytic syndrome. Acyclovir was initiated a median (interquartile range) of 1 (0-3) day after admission.

Keywords: ICU; acute liver failure; acyclovir; hemophagocytic syndrome; herpes simplex virus.

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Conflict of interest statement

Potential conflicts of interest. All authors: no reported conflicts.

Figures

Graphical Abstract
Graphical Abstract
https://tidbitapp.io/tidbits/severe-herpes-simplex-virus-hepatitis-a-retrospective-multicenter-observational-study
See this image and copyright information in PMC

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